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8J25
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BU of 8j25 by Molmil
Crystal structure of PML B-box2 mutant
Descriptor: Maltose/maltodextrin-binding periplasmic protein,Protein PML, ZINC ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Zhou, C, Zang, N, Zhang, J.
Deposit date:2023-04-14
Release date:2023-09-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function.
Cancer Discov, 13, 2023
3FDD
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BU of 3fdd by Molmil
The Crystal Structure of the Pseudomonas dacunhae Aspartate-Beta-Decarboxylase Reveals a Novel Oligomeric Assembly for a Pyridoxal-5-Phosphate Dependent Enzyme
Descriptor: ACETATE ION, CHLORIDE ION, L-aspartate-beta-decarboxylase, ...
Authors:Lima, S, Sundararaju, B, Huang, C, Khristoforov, R, Momany, C, Phillips, R.S.
Deposit date:2008-11-25
Release date:2009-03-17
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The crystal structure of the Pseudomonas dacunhae aspartate-beta-decarboxylase dodecamer reveals an unknown oligomeric assembly for a pyridoxal-5'-phosphate-dependent enzyme.
J.Mol.Biol., 388, 2009
4E0V
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BU of 4e0v by Molmil
Structure of L-amino acid oxidase from the B. jararacussu venom
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, L-amino-acid oxidase
Authors:Ullah, A, Souza, T.A.C.B, Betzel, C, Murakami, M.T, Arni, R.K.
Deposit date:2012-03-05
Release date:2012-04-25
Last modified:2012-08-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural insights into selectivity and cofactor binding in snake venom L-amino acid oxidases.
Biochem.Biophys.Res.Commun., 421, 2012
6D3F
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BU of 6d3f by Molmil
Crystal Structure of the PTP epsilon D2 domain
Descriptor: Receptor-type tyrosine-protein phosphatase epsilon
Authors:Lountos, G.T, Raran-Kurussi, S, Zhao, B.M, Dyas, B.K, Austin, B.P, Burke Jr, T.R, Ulrich, R.G, Waugh, D.S.
Deposit date:2018-04-16
Release date:2018-10-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.271 Å)
Cite:High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design.
Acta Crystallogr D Struct Biol, 74, 2018
6D4F
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BU of 6d4f by Molmil
Crystal structure of PTP epsilon D2 domain (A455N/V457Y/E597D)
Descriptor: PENTAETHYLENE GLYCOL, Receptor-type tyrosine-protein phosphatase epsilon
Authors:Lountos, G.T, Raran-Kurussi, S, Zhao, B.M, Dyas, B.K, Austin, B.P, Burke Jr, T.R, Ulrich, R.G, Waugh, D.S.
Deposit date:2018-04-18
Release date:2018-10-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.909 Å)
Cite:High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design.
Acta Crystallogr D Struct Biol, 74, 2018
6D4D
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BU of 6d4d by Molmil
Crystal structure of the PTP epsilon D1 domain
Descriptor: Receptor-type tyrosine-protein phosphatase epsilon
Authors:Lountos, G.T, Raran-Kurussi, S, Zhao, B.M, Dyas, B.K, Austin, B.P, Burke Jr, T.R, Ulrich, R.G, Waugh, D.S.
Deposit date:2018-04-18
Release date:2018-10-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.765 Å)
Cite:High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design.
Acta Crystallogr D Struct Biol, 74, 2018
3I3H
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BU of 3i3h by Molmil
Crystal structure of Bothropstoxin-I crystallized at 291K
Descriptor: Phospholipase A2 homolog bothropstoxin-1
Authors:Salvador, G.H.M, Marchi-Salvador, D.P, Soares, A.M, Fontes, M.R.M.
Deposit date:2009-06-30
Release date:2010-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structural Studies with a BthTX-I a Lys49 PLA2 from Bothrops jararacussu Snake Venom Crystallized at Different Temperatures
To be Published
1T60
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BU of 1t60 by Molmil
Crystal structure of Type IV collagen NC1 domain from bovine lens capsule
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, POTASSIUM ION, ...
Authors:Vanacore, R.M, Shanmugasundararaj, S, Friedman, D.B, Bondar, O, Hudson, B.G, Sundaramoorthy, M.
Deposit date:2004-05-05
Release date:2004-09-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The alpha1.alpha2 network of collagen IV. Reinforced stabilization of the noncollagenous domain-1 by noncovalent forces and the absence of Met-Lys cross-links
J.Biol.Chem., 279, 2004
4AZE
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BU of 4aze by Molmil
Human DYRK1A in complex with Leucettine L41
Descriptor: 5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one, DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A
Authors:Elkins, J.M, Soundararajan, M, Muniz, J.R.C, Tahtouh, T, Burgy, G, Durieu, E, Lozach, O, Cochet, C, Schmid, R.S, Lo, D.C, Delhommel, F, Carreaux, F, Bazureau, J.P, Meijer, L, Edwards, A, Bountra, C, Knapp, S.
Deposit date:2012-06-25
Release date:2012-09-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Selectivity, Co-Crystal Structures and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B.
J.Med.Chem., 55, 2012
4AZF
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BU of 4azf by Molmil
Human DYRK2 in complex with Leucettine L41
Descriptor: 1,2-ETHANEDIOL, 5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one, DYRK2 DUAL-SPECIFICITY TYROSINE-PHOSPHORYLATION REGULATED KINASE 2, ...
Authors:Elkins, J.M, Soundararajan, M, Muniz, J.R.C, Tahtouh, T, Burgy, G, Durieu, E, Lozach, O, Cochet, C, Schmid, R.S, Lo, D.C, Delhommel, F, Carreaux, F, Bazureau, J.P, Meijer, L, Edwards, A, Bountra, C, Knapp, S.
Deposit date:2012-06-25
Release date:2012-09-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Selectivity, Co-Crystal Structures and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B.
J.Med.Chem., 55, 2012
1UMV
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BU of 1umv by Molmil
Crystal structure of an acidic, non-myotoxic phospholipase A2 from the venom of Bothrops jararacussu
Descriptor: CALCIUM ION, HYPOTENSIVE PHOSPHOLIPASE A2
Authors:Murakami, M.T, Watanabe, L, Cintra, A.C.O, Arni, R.K.
Deposit date:2003-08-28
Release date:2003-09-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Crystal Structure of an Acidic Platelet Aggregation Inhibitor and Hypotensive Phospholipase A(2) in the Monomeric and Dimeric States: Insights Into its Oligomeric State
Biochem.Biophys.Res.Commun., 323, 2004
1NCV
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BU of 1ncv by Molmil
DETERMINATION CC-CHEMOKINE MCP-3, NMR, 7 STRUCTURES
Descriptor: MONOCYTE CHEMOATTRACTANT PROTEIN 3
Authors:Meunier, S, Bernassau, J.M, Guillemot, J.C, Ferrara, P, Darbon, H.
Deposit date:1997-02-05
Release date:1997-10-15
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy.
Biochemistry, 36, 1997
2WNM
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BU of 2wnm by Molmil
Solution structure of Gp2
Descriptor: GENE 2
Authors:Camara, B, Liu, M, Shadrinc, A, Liu, B, Simpson, P, Weinzierl, R, Severinovc, K, Cota, E, Matthews, S, Wigneshweraraj, S.R.
Deposit date:2009-07-13
Release date:2010-02-16
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:T7 Phage Protein Gp2 Inhibits the Escherichia Coli RNA Polymerase by Antagonizing Stable DNA Strand Separation Near the Transcription Start Site.
Proc.Natl.Acad.Sci.USA, 107, 2010
3CEK
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BU of 3cek by Molmil
Crystal structure of human dual specificity protein kinase (TTK)
Descriptor: 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, Dual specificity protein kinase TTK
Authors:Filippakopoulos, P, Soundararajan, M, Keates, T, Elkins, J.M, King, O, Fedorov, O, Picaud, S.S, Pike, A.C.W, Roos, A, Pilka, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2008-02-29
Release date:2008-03-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.
Nat.Chem.Biol., 6, 2010
2IHD
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BU of 2ihd by Molmil
Crystal structure of Human Regulator of G-protein signaling 8, RGS8
Descriptor: CHLORIDE ION, Regulator of G-protein signaling 8
Authors:Turnbull, A.P, Papagrigoriou, E, Ugochukwu, E, Salah, E, Gileadi, C, Burgess, N, Bhatia, C, Gileadi, O, Bray, J, Elkins, J, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Doyle, D.A, Structural Genomics Consortium (SGC)
Deposit date:2006-09-26
Release date:2006-11-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
6FIB
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BU of 6fib by Molmil
Structure of human 4-1BB ligand
Descriptor: Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor ligand superfamily member 9,4-1BBL -CH/CL fusion, Tumor necrosis factor ligand superfamily member 9,Uncharacterized protein
Authors:Joseph, C, Claus, C, Ferrara, C, von Hirschheydt, T, Prince, C, Funk, D, Klein, C, Benz, J.
Deposit date:2018-01-17
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.
Sci Transl Med, 11, 2019
4Z8E
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BU of 4z8e by Molmil
TEAD DBD mutant -deltaL1
Descriptor: Transcriptional enhancer factor TEF-1
Authors:Lee, D.-S, Albarado, D.C, Vonrhein, C, Raman, C.S, Veeraraghavan, S.
Deposit date:2015-04-08
Release date:2016-04-13
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.092 Å)
Cite:A Potential Structural Switch for Regulating DNA-Binding by TEAD Transcription Factors.
J.Mol.Biol., 428, 2016
1ZLB
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BU of 1zlb by Molmil
Crystal structure of catalytically-active phospholipase A2 in the absence of calcium
Descriptor: hypotensive phospholipase A2
Authors:Murakami, M.T, Cintra, A.C, Gabdoulkhakov, A, Genov, N, Betzel, C, Arni, R.K.
Deposit date:2005-05-05
Release date:2006-04-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (0.97 Å)
Cite:Insights into metal ion binding in phospholipases A(2): ultra high-resolution crystal structures of an acidic phospholipase A(2) in the Ca(2+) free and bound states.
Biochimie, 88, 2006
5AIK
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BU of 5aik by Molmil
Human DYRK1A in complex with LDN-211898
Descriptor: 4-(7-METHOXY-1-(TRIFLUOROMETHYL)-9H-PYRIDO[3,4-B]INDOL-9-yl)butan-1-amine, DYRK1A DUAL-SPECIFICITY TYROSINE-PHOSPHORYLATION REGULATED KINASE 1A, PHOSPHATE ION
Authors:Elkins, J.M, Soundararajan, M, Muniz, J.R.C, Cuny, G, Higgins, J, Edwards, A, Bountra, C, Knapp, S.
Deposit date:2015-02-15
Release date:2015-02-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Dyrk1A with Ldn-211898
To be published
1ZL7
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BU of 1zl7 by Molmil
Crystal structure of catalytically-active phospholipase A2 with bound calcium
Descriptor: CALCIUM ION, GLYCEROL, hypotensive phospholipase A2
Authors:Murakami, M.T, Cintra, A.C, Gabdoulkhakov, A, Genov, N, Betzel, C, Arni, R.K.
Deposit date:2005-05-05
Release date:2006-04-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Insights into metal ion binding in phospholipases A(2): ultra high-resolution crystal structures of an acidic phospholipase A(2) in the Ca(2+) free and bound states.
Biochimie, 88, 2006
1Z76
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BU of 1z76 by Molmil
Crystal structure of an acidic phospholipase A2 (BthA-I) from Bothrops jararacussu venom complexed with p-bromophenacyl bromide
Descriptor: p-Bromophenacyl bromide, phospholipase A2
Authors:Magro, A.J, Takeda, A.A, Soares, A.M, Fontes, M.R.
Deposit date:2005-03-24
Release date:2006-03-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of BthA-I complexed with p-bromophenacyl bromide: possible correlations with lack of pharmacological activity.
Acta Crystallogr.,Sect.D, 61, 2005
3KVW
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BU of 3kvw by Molmil
Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand
Descriptor: (2Z,3E)-7'-bromo-3-(hydroxyimino)-2'-oxo-1,1',2',3-tetrahydro-2,3'-biindole-5-carboxylic acid, CHLORIDE ION, Dual specificity tyrosine-phosphorylation-regulated kinase 2
Authors:Filippakopoulos, P, Myrianthopoulos, V, Kritsanida, M, Magiatis, P, Skaltsounis, A.L, Soundararajan, M, Krojer, T, Gileadi, O, Hapka, E, Fedorov, O, Berridge, G, Wang, J, Shrestha, L, Vollmar, M, von Delft, F, Arrowsmith, C.H, Edwards, A, Weigelt, J, Bountra, C, Mikros, E, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2009-11-30
Release date:2010-01-05
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand
To be Published
1TLB
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BU of 1tlb by Molmil
Yeast coproporphyrinogen oxidase
Descriptor: Coproporphyrinogen III oxidase, SULFATE ION
Authors:Phillip, J.D, Whitby, F.G, Warby, C.A, Labbe, P, Yang, C, Pflugrath, J.W, Ferrara, J.D, Robinson, H, Kushner, J.P, Hill, C.P.
Deposit date:2004-06-09
Release date:2004-07-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the oxygen-dependent coproporphyrinogen oxidase (Hem13p) of Saccharomyces cerevisiae
J.Biol.Chem., 279, 2004
1TK1
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YEAST OXYGEN-DEPENDENT COPROPORPHYRINOGEN OXIDASE
Descriptor: Coproporphyrinogen III oxidase
Authors:Phillips, J.D, Whitby, F.G, Warby, C.A, Labbe, P, Yang, C, Pflugrath, J.W, Ferrara, J.D, Robinson, H, Kushner, J.P, Hill, C.P.
Deposit date:2004-06-08
Release date:2004-07-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the Oxygen-dependant Coproporphyrinogen Oxidase (Hem13p) of Saccharomyces cerevisiae
J.Biol.Chem., 279, 2004
1TKL
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BU of 1tkl by Molmil
Yeast Oxygen-Dependent Coproporphyrinogen Oxidase
Descriptor: Coproporphyrinogen III oxidase
Authors:Phillips, J.D, Whitby, F.G, Warby, C.A, Labbe, P, Yang, C, Pflugrath, J.W, Ferrara, J.D, Robinson, H, Kushner, J.P, Hill, C.P.
Deposit date:2004-06-08
Release date:2004-07-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Oxygen-dependant Coproporphyrinogen Oxidase (Hem13p) of Saccharomyces cerevisiae
J.Biol.Chem., 279, 2004

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