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5D4C	Crystal structure of Thermus thermophilus product complex for transcription initiation with ATP and CTP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2015-08-07 Release date: 2016-07-06 Last modified: 2024-07-03 Method: X-RAY DIFFRACTION (3.28 Å) Cite: The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA. Nature, 535, 2016
5D4E	Crystal structure of Thermus thermophilus product complex for transcription initiation with 3'-dephosphate-CoA and CTP Descriptor: CYTIDINE-5'-MONOPHOSPHATE, DEPHOSPHO COENZYME A, DIPHOSPHATE, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2015-08-07 Release date: 2016-07-06 Last modified: 2024-07-03 Method: X-RAY DIFFRACTION (3.08 Å) Cite: The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA. Nature, 535, 2016
1L9U	THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME AT 4 A RESOLUTION Descriptor: MAGNESIUM ION, RNA POLYMERASE, ALPHA SUBUNIT, ... Authors: Murakami, K.S, Masuda, S, Darst, S.A. Deposit date: 2002-03-26 Release date: 2002-05-22 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (4 Å) Cite: Structural basis of transcription initiation: RNA polymerase holoenzyme at 4 A resolution. Science, 296, 2002
5XJ0	T. thermophilus RNA polymerase holoenzyme bound with gp39 and gp76 Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Ooi, W.Y, Murayama, Y, Mekler, V, Minakhin, L, Severinov, K, Yokoyama, S, Sekine, S. Deposit date: 2017-04-28 Release date: 2017-12-20 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (4.004 Å) Cite: A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation Nucleic Acids Res., 46, 2018
1KU2	Crystal Structure of Thermus aquaticus RNA Polymerase Sigma Subunit Fragment Containing Regions 1.2 to 3.1 Descriptor: SULFATE ION, sigma factor sigA Authors: Campbell, E.A, Muzzin, O, Chlenov, M, Sun, J.L, Olson, C.A, Weinman, O, Trester-Zedlitz, M.L, Darst, S.A. Deposit date: 2002-01-21 Release date: 2002-04-03 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure of the bacterial RNA polymerase promoter specificity sigma subunit. Mol.Cell, 9, 2002
5E17	T. thermophilus transcription initiation complex having a RRR discriminator sequence and a nontemplate-strand length corresponding to TSS selection at position 7 (RPo-GGG-7) Descriptor: DNA (27-MER), DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2015-09-29 Release date: 2016-03-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Multiplexed protein-DNA cross-linking: Scrunching in transcription start site selection. Science, 351, 2016
1ZYR	Structure of Thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic streptolydigin Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase omega chain, ... Authors: Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E. Deposit date: 2005-06-10 Release date: 2005-09-13 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (3 Å) Cite: Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation. Cell(Cambridge,Mass.), 122, 2005
1L9Z	Thermus aquaticus RNA Polymerase Holoenzyme/Fork-Junction Promoter DNA Complex at 6.5 A Resolution Descriptor: MAGNESIUM ION, RNA POLYMERASE, ALPHA SUBUNIT, ... Authors: Murakami, K.S, Masuda, S, Campbell, E.A, Muzzin, O, Darst, S.A. Deposit date: 2002-03-27 Release date: 2002-05-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (6.5 Å) Cite: Structural basis of transcription initiation: an RNA polymerase holoenzyme-DNA complex. Science, 296, 2002
2A6E	Crystal structure of the T. Thermophilus RNA polymerase holoenzyme Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... Authors: Artsimovitch, I, Vassylyeva, M.N, Svetlov, D, Svetlov, V, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Tahirov, T.H, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-07-02 Release date: 2005-09-20 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell(Cambridge,Mass.), 122, 2005
2A6H	Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic sterptolydigin Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... Authors: Temiakov, D, Zenkin, N, Vassylyeva, M.N, Perederina, A, Tahirov, T.H, Savkina, M, Zorov, S, Nikiforov, V, Igarashi, N, Matsugaki, N, Wakatsuki, S, Severinov, K, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-07-02 Release date: 2005-09-20 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis of transcription inhibition by antibiotic streptolydigin. Mol.Cell, 19, 2005
2A69	Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic rifapentin Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... Authors: Artsimovitch, I, Vassylyeva, M.N, Svetlov, D, Svetlov, V, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Tahirov, T.H, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-07-02 Release date: 2005-09-20 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell(Cambridge,Mass.), 122, 2005
7XL4	Cryo-EM structure of Pseudomonas aeruginosa RNAP sigmaS holoenzyme complexes with transcription factor SutA (closed lobe) Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: He, D.W, You, L.L, Zhang, Y. Deposit date: 2022-04-21 Release date: 2022-07-27 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.86 Å) Cite: Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding. Nat Commun, 13, 2022
7XL3	Cryo-EM structure of Pseudomonas aeruginosa RNAP sigmaS holoenzyme complexes with transcription factor SutA (open lobe) Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: He, D.W, You, L.L, Zhang, Y. Deposit date: 2022-04-21 Release date: 2022-07-27 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.13 Å) Cite: Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding. Nat Commun, 13, 2022
7X76	Cryo-EM structure of Streptomyces coelicolor RNAP-promoter open complex with two Zur dimers Descriptor: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Yang, X, Zheng, J. Deposit date: 2022-03-09 Release date: 2022-08-03 Last modified: 2022-08-24 Method: ELECTRON MICROSCOPY (3.67 Å) Cite: Structural basis of Streptomyces transcription activation by zinc uptake regulator. Nucleic Acids Res., 50, 2022
7X74	Cryo-EM structure of Streptomyces coelicolor transcription initial complex with two Zur dimers. Descriptor: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Yang, X, Zheng, J. Deposit date: 2022-03-09 Release date: 2022-08-03 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural basis of Streptomyces transcription activation by zinc uptake regulator. Nucleic Acids Res., 50, 2022
7X75	Cryo-EM structure of Streptomyces coelicolor RNAP-promoter open complex with three Zur dimers Descriptor: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Yang, X, Zheng, J. Deposit date: 2022-03-09 Release date: 2022-08-03 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.45 Å) Cite: Structural basis of Streptomyces transcription activation by zinc uptake regulator. Nucleic Acids Res., 50, 2022
6EEC	Mycobacterium tuberculosis RNAP promoter unwinding intermediate complex with RbpA/CarD and AP3 promoter captured by Corallopyronin Descriptor: DNA (63-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. Deposit date: 2018-08-13 Release date: 2018-11-21 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.55 Å) Cite: Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
6EDT	Mycobacterium tuberculosis RNAP open promoter complex with RbpA/CarD and AP3 promoter Descriptor: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. Deposit date: 2018-08-10 Release date: 2018-11-21 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY Cite: Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
6EE8	Mycobacterium tuberculosis RNAP promoter unwinding intermediate complex with RbpA/CarD and AP3 promoter Descriptor: DNA (60-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. Deposit date: 2018-08-13 Release date: 2018-11-21 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.92 Å) Cite: Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
6EYD	Structure of Mycobacterium smegmatis RNA polymerase Sigma-A holoenzyme Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Kouba, T, Barvik, I, Krasny, L. Deposit date: 2017-11-11 Release date: 2018-12-12 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4.22 Å) Cite: The Core and Holoenzyme Forms of RNA Polymerase fromMycobacterium smegmatis. J. Bacteriol., 201, 2019
8W8O	Thermus thermophilus initiation complex in the half-translocated state Descriptor: DNA (21-MER), DNA (27-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2023-09-04 Release date: 2024-07-24 Method: X-RAY DIFFRACTION (2.512 Å) Cite: Nanopore tweezers show fractional-nucleotide translocation in sequence-dependent pausing by RNA polymerase. Proc.Natl.Acad.Sci.USA, 121, 2024
8W8P	Thermus thermophilus initiation transcription complex containing CMPcPP in the post-translocated state Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (21-MER), DNA (27-MER), ... Authors: Li, L, Zhang, Y. Deposit date: 2023-09-04 Release date: 2024-07-24 Method: X-RAY DIFFRACTION (3.165 Å) Cite: Nanopore tweezers show fractional-nucleotide translocation in sequence-dependent pausing by RNA polymerase. Proc.Natl.Acad.Sci.USA, 121, 2024
8W8N	Thermus thermophilus initiation transcription complex in the pre-translocated state Descriptor: DNA (21-MER), DNA (27-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2023-09-04 Release date: 2024-07-24 Method: X-RAY DIFFRACTION (2.693 Å) Cite: Nanopore tweezers show fractional-nucleotide translocation in sequence-dependent pausing by RNA polymerase. Proc.Natl.Acad.Sci.USA, 121, 2024
6FBV	Single particle cryo em structure of Mycobacterium tuberculosis RNA polymerase in complex with Fidaxomicin Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Das, K, Lin, W, Ebright, E. Deposit date: 2017-12-19 Release date: 2018-02-28 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.52 Å) Cite: Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3). Mol. Cell, 70, 2018
8X6F	Cryo-EM structure of Staphylococcus aureus sigA-dependent RNAP-promoter open complex Descriptor: DNA (71-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Yuan, L, Xu, L, Liu, Q, Feng, Y. Deposit date: 2023-11-21 Release date: 2024-06-05 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural basis of promoter recognition by Staphylococcus aureus RNA polymerase. Nat Commun, 15, 2024

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