6EEC

Mycobacterium tuberculosis RNAP promoter unwinding intermediate complex with RbpA/CarD and AP3 promoter captured by Corallopyronin

Summary for 6EEC

Entry DOI	10.2210/pdb6eec/pdb
EMDB information	9037 9039 9041
Descriptor	DNA-directed RNA polymerase subunit alpha, methyl [(1E,5R)-5-{(3E)-3-[(2E,4E,8R,9E,12E)-1,8-dihydroxy-2,5,9-trimethyltetradeca-2,4,9,12-tetraen-1-ylidene]-2,4-dioxo-3,4-d ihydro-2H-pyran-6-yl}hex-1-en-1-yl]carbamate, ZINC ION, ... (12 entities in total)
Functional Keywords	initiation, transcription bubble, closed clamp, open promoter complex, transcription, transcription-dna complex, transcription/dna
Biological source	Mycobacterium tuberculosis More
Total number of polymer chains	10
Total formula weight	510846.41
Authors	Darst, S.A.,Campbell, E.A.,Boyaci Selcuk, H.,Chen, J. (deposition date: 2018-08-13, release date: 2018-11-21, Last modification date: 2024-03-13)
Primary citation	Boyaci, H.,Chen, J.,Jansen, R.,Darst, S.A.,Campbell, E.A. Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565:382-385, 2019 Cited by PubMed: 30626968 DOI: 10.1038/s41586-018-0840-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.55 Å)

Structure validation