PDB: 250 件ウェブページステータス検索Chemie searchBIRD

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4UF0	Crystal structure of JmjC domain of human histone demethylase UTY in complex with epitherapuetic compound 2-(((2-((2-(dimethylamino)ethyl) (ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid. 分子名称: 1,2-ETHANEDIOL, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, FE (II) ION, ... 著者 Srikannathasan, V, Johansson, C, Gileadi, C, Tobias, K, Kopec, J, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U. 登録日 2014-12-22 公開日 2015-01-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016
3KQI	crystal structure of PHF2 PHD domain complexed with H3K4Me3 peptide 分子名称: CHLORIDE ION, GLYCEROL, H3K4Me3 peptide, ... 著者 Wen, H, Li, J.Z, Song, T, Lu, M, Lee, M. 登録日 2009-11-17 公開日 2010-02-02 最終更新日 2019-02-13 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation. J.Biol.Chem., 285, 2010
6LUI	Crystal structure of the SAMD1 WH domain and DNA complex 分子名称: Atherin, DNA (5'-D(*AP*CP*CP*TP*GP*CP*GP*CP*AP*CP*CP*AP*T)-3'), DNA (5'-D(*AP*TP*GP*GP*TP*GP*CP*GP*CP*AP*GP*GP*T)-3') 著者 Zhou, Y, Cao, Y, Wang, Z. 登録日 2020-01-29 公開日 2021-02-03 最終更新日 2021-07-07 実験手法 X-RAY DIFFRACTION (1.781 Å) 主引用文献 The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv, 7, 2021
2QQR	JMJD2A hybrid tudor domains 分子名称: JmjC domain-containing histone demethylation protein 3A, SULFATE ION 著者 Lee, J, Botuyan, M.V, Mer, G. 登録日 2007-07-26 公開日 2007-12-11 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor. Nat.Struct.Mol.Biol., 15, 2008
8GTX	Crystal Structure of human Spindlin1-HBx complex 分子名称: GLYCEROL, HBx, Spindlin-1 著者 Li, H, Liu, W. 登録日 2022-09-09 公開日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structure of human Spindlin1-HBx complex To be published
3QZS	Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form I 分子名称: Histone H4, Nucleosome-remodeling factor subunit BPTF 著者 Li, H, Ruthenburg, A.J, Patel, D.J. 登録日 2011-03-07 公開日 2011-06-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions. Cell(Cambridge,Mass.), 145, 2011
2V87	Crystal structure of RAG2-PHD finger in complex with H3R2me2sK4me3 peptide 分子名称: HISTONE H3.2, VDJ RECOMBINATION-ACTIVATING PROTEIN 2, ZINC ION 著者 Ramon-Maiques, S, Yang, W. 登録日 2007-08-02 公開日 2007-12-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The Plant Homeodomain Finger of Rag2 Recognizes Histone H3 Methylated at Both Lysine-4 and Arginine-2. Proc.Natl.Acad.Sci.USA, 104, 2007
3UR4	Crystal structure of human WD repeat domain 5 with compound 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ... 著者 Dong, A, Dombrovski, L, Senisterra, G, Wernimont, A, Wasney, G.A, Allali Hassani, A, Nguyen, K.T, Smil, D, Bolshan, Y, Hajian, T, Poda, G, Chau, I, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Brown, P, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) 登録日 2011-11-21 公開日 2011-12-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem. J., 449, 2013
2PNX	The PHD finger of ING4 in complex with an H3K4Me3 histone peptide 分子名称: H3K4Me3 peptide, Inhibitor of growth protein 4, ZINC ION 著者 Champagne, K.S, Johnson, K, Kutateladze, T.G. 登録日 2007-04-25 公開日 2008-04-15 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation Mol.Cell, 33, 2009
3SMR	Crystal structure of human WD repeat domain 5 with compound 分子名称: 1,2-ETHANEDIOL, 2-chloro-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, UNKNOWN ATOM OR ION, ... 著者 Dong, A, Dombrovski, L, Wasney, G.A, Tempel, W, Senisterra, G, Bolshan, Y, Smil, D, Nguyen, K.T, Hajian, T, Poda, G, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Brown, P.J, Schapira, M, Arrowsmith, C.H, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) 登録日 2011-06-28 公開日 2011-08-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem. J., 449, 2013
3MEV	Crystal structure of SGF29 in complex with R2AK4me3 分子名称: GLYCEROL, Histone H3, SAGA-associated factor 29 homolog, ... 著者 Bian, C.B, Xu, C, Lam, R, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) 登録日 2010-03-31 公開日 2010-04-28 最終更新日 2021-10-06 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. Embo J., 30, 2011
5VAR	Crystal structure of KDM4A tandem TUDOR domain in complex with a tri-methyl lysine competitive inhibitor 分子名称: (1R,2S,3R,4S)-3-[(dimethylamino)methyl]-1-phenylbicyclo[2.2.1]heptan-2-ol, Lysine-specific demethylase 4A 著者 Judge, R.A, Upadhyay, A.K. 登録日 2017-03-27 公開日 2018-03-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain - A fragment based approach. Bioorg. Med. Chem. Lett., 28, 2018
5XVW	Crystal structure of AL2 PAL domain in complex with AtRing1a distal site 分子名称: AtRing1a distal binding site, PHD finger protein ALFIN-LIKE 2 著者 Peng, L, Wang, L.L, Huang, Y. 登録日 2017-06-28 公開日 2018-07-04 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.849 Å) 主引用文献 Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch J. Mol. Biol., 430, 2018
3O70	PHD-type zinc finger of human PHD finger protein 13 分子名称: GLYCEROL, PHD finger protein 13, ZINC ION 著者 Lam, R, Bian, C.B, Xu, C, Kania, J, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) 登録日 2010-07-29 公開日 2010-09-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3. Elife, 5, 2016
4UY4	1.86 A structure of human Spindlin-4 protein in complex with histone H3K4me3 peptide 分子名称: GLYCEROL, HISTONE H3K4ME3, SPINDLIN-4 著者 Talon, R, Gileadi, C, Johansson, C, Burgess-Brown, N, Shrestha, L, von Delft, F, Krojer, T, Fairhead, M, Bountra, C, Arrowsmith, C.H, Edwards, A, Oppermann, U. 登録日 2014-08-28 公開日 2014-09-24 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.862 Å) 主引用文献 1.86 A Structure of Human Spindlin-4 Protein in Complex with Histone H3K4Me3 Peptide To be Published
5F5C	Crystal Structure of human JMJD2D complexed with KDOPP7 分子名称: 1,2-ETHANEDIOL, 8-[[(phenylmethyl)amino]methyl]-1~{H}-pyrido[3,4-d]pyrimidin-4-one, Lysine-specific demethylase 4D, ... 著者 Krojer, T, Vollmar, M, Crawley, L, Bradley, A.R, Szykowska, A, Ruda, G.F, Yang, H, Burgess-Brown, N, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, Oppermann, U, von Delft, F, Structural Genomics Consortium (SGC) 登録日 2015-12-04 公開日 2015-12-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5KR7	KDM4C bound to pyrazolo-pyrimidine scaffold 分子名称: 6-ethyl-2,5-dimethyl-7-oxidanylidene-4~{H}-pyrazolo[1,5-a]pyrimidine-3-carbonitrile, CHLORIDE ION, FE (II) ION, ... 著者 Bellon, S.F, Poy, F, Setser, J.W. 登録日 2016-07-07 公開日 2016-08-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Identification of potent, selective KDM5 inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
3LQJ	Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide 分子名称: Histone H3, MLL1 PHD3-Bromo, ZINC ION 著者 Wang, Z, Patel, D.J. 登録日 2010-02-09 公開日 2010-07-07 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell(Cambridge,Mass.), 141, 2010
3GL6	Crystal structure of JARID1A-PHD3 complexed with H3(1-9)K4me3 peptide 分子名称: Histone H3, Histone demethylase JARID1A, ZINC ION 著者 Wang, Z, Song, J, Patel, D.J. 登録日 2009-03-11 公開日 2009-05-05 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature, 459, 2009
2FSA	Crystal structure of PHD finger-linker-bromodomain fragment of human BPTF in the H3(1-15)K4ME2 bound state 分子名称: Histone H3(1-15)K4me2 peptide, ZINC ION, bromodomain PHD finger transcription factor 著者 Li, H, Patel, D.J. 登録日 2006-01-21 公開日 2006-07-11 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature, 442, 2006
5A3T	Crystal structure of human PLU-1 (JARID1B) in complex with KDM5-C49 (2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl) isonicotinic acid). 分子名称: 1,2-ETHANEDIOL, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Srikannathasan, V, Johansson, C, Gileadi, C, Kopec, J, Strain-Damerell, C, Kupinska, K, BurgessBrown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Oppermann, U. 登録日 2015-06-02 公開日 2015-06-17 最終更新日 2016-06-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016
6LQE	Crystal structure of Arabidopsis ARID5 PHD finger in complex with H3K4me3 peptide 分子名称: 15-mer peptide from Histone H3.2, AT-rich interactive domain-containing protein 4, ZINC ION 著者 Liu, R, Du, J. 登録日 2020-01-13 公開日 2020-06-03 最終更新日 2020-08-19 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Dual Recognition of H3K4me3 and DNA by the ISWI Component ARID5 Regulates the Floral Transition in Arabidopsis. Plant Cell, 32, 2020
5WMF	Crystal structure of the Hexameric Ring of Epstein-Barr Virus Nuclear Antigen-1, EBNA1 分子名称: Epstein-Barr nuclear antigen 1 著者 Messick, T.E. 登録日 2017-07-28 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and Functional Basis for an EBNA1 Hexameric Ring in Epstein-Barr Virus Episome Maintenance. J. Virol., 91, 2017
3QLN	Crystal structure of ATRX ADD domain in free state 分子名称: Transcriptional regulator ATRX, ZINC ION 著者 Li, H, Patel, D.J. 登録日 2011-02-03 公開日 2011-06-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.901 Å) 主引用文献 ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome Nat.Struct.Mol.Biol., 18, 2011
3LQI	Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me2 peptide 分子名称: Histone H3, MLL1 PHD3-Bromo, ZINC ION 著者 Wang, Z, Patel, D.J. 登録日 2010-02-09 公開日 2010-07-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell(Cambridge,Mass.), 141, 2010

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