5VAR

Crystal structure of KDM4A tandem TUDOR domain in complex with a tri-methyl lysine competitive inhibitor

Summary for 5VAR

Entry DOI	10.2210/pdb5var/pdb
Descriptor	Lysine-specific demethylase 4A, (1R,2S,3R,4S)-3-[(dimethylamino)methyl]-1-phenylbicyclo[2.2.1]heptan-2-ol (3 entities in total)
Functional Keywords	kdm4a tandem tudor domain, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	13788.26
Authors	Judge, R.A.,Upadhyay, A.K. (deposition date: 2017-03-27, release date: 2018-03-28, Last modification date: 2023-10-04)
Primary citation	Upadhyay, A.K.,Judge, R.A.,Li, L.,Pithawalla, R.,Simanis, J.,Bodelle, P.M.,Marin, V.L.,Henry, R.F.,Petros, A.M.,Sun, C. Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain - A fragment based approach. Bioorg. Med. Chem. Lett., 28:1708-1713, 2018 Cited by PubMed: 29691138 DOI: 10.1016/j.bmcl.2018.04.050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.83 Å)

Structure validation