8E2G
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8E2J
| Cryo-EM structure of BIRC6/Smac (from local refinement 1) | Descriptor: | Baculoviral IAP repeat-containing protein 6, Diablo IAP-binding mitochondrial protein | Authors: | Hunkeler, M, Fischer, E.S. | Deposit date: | 2022-08-15 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases. Science, 379, 2023
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8DPK
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8E2E
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8E2F
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8E2H
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8DRO
| LRRC8A:C conformation 1 (round) LRR focus 2 | Descriptor: | Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562 | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-07-21 | Release date: | 2023-03-08 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4.06 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8DRA
| LRRC8A:C conformation 2 (oblong) LRR mask | Descriptor: | Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-07-20 | Release date: | 2023-03-08 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.98 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8DRN
| LRRC8A:C conformation 1 (round) LRR focus 1 | Descriptor: | Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-07-21 | Release date: | 2023-03-08 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4.12 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8DNY
| Cryo-EM structure of the human Sec61 complex inhibited by decatransin | Descriptor: | Decatransin peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... | Authors: | Park, E, Itskanov, S. | Deposit date: | 2022-07-12 | Release date: | 2023-05-24 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
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8DNZ
| Cryo-EM structure of the human Sec61 complex inhibited by apratoxin F | Descriptor: | Apratoxin F peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... | Authors: | Park, E, Itskanov, S. | Deposit date: | 2022-07-12 | Release date: | 2023-05-24 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.57 Å) | Cite: | A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
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8DO3
| Cryo-EM structure of the human Sec61 complex inhibited by eeyarestatin I | Descriptor: | N'-(4-chlorophenyl)-N-[(4R)-3-(4-chlorophenyl)-5,5-dimethyl-1-(2-{(2E)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinyl}-2-oxoethyl)-2-oxoimidazolidin-4-yl]-N-hydroxyurea, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... | Authors: | Park, E, Itskanov, S. | Deposit date: | 2022-07-12 | Release date: | 2023-05-24 | Last modified: | 2023-09-06 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
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8DNX
| Cryo-EM structure of the human Sec61 complex inhibited by cotransin | Descriptor: | Cotransin analogue peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... | Authors: | Park, E, Itskanov, S. | Deposit date: | 2022-07-12 | Release date: | 2023-05-24 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
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8DNV
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8DNW
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8DO2
| Cryo-EM structure of the human Sec61 complex inhibited by cyclotriazadisulfonamide (CADA) | Descriptor: | 9-benzyl-1,5-bis(4-methylbenzene-1-sulfonyl)-3-methylidene-1,5,9-triazacyclododecane, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... | Authors: | Park, E, Itskanov, S. | Deposit date: | 2022-07-12 | Release date: | 2023-05-24 | Last modified: | 2023-09-06 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
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8EL2
| SARS-CoV-2 RBD bound to neutralizing antibody Fab ICO-hu23 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab ICO-hu23 Heavy Chain, Fab ICO-hu23 Light Chain, ... | Authors: | Besaw, J.E, Kuo, A, Morizumi, T, Ernst, O.P. | Deposit date: | 2022-09-22 | Release date: | 2023-07-19 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates. Plos Pathog., 19, 2023
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8DQA
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8DOT
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8EHK
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8EHM
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8EHL
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8EHJ
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8EYR
| Cryo-EM structure of two IGF1 bound full-length mouse IGF1R mutant (four glycine residues inserted in the alpha-CT; IGF1R-P674G4): symmetric conformation | Descriptor: | Insulin-like growth factor 1 receptor, Insulin-like growth factor I | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | Deposit date: | 2022-10-28 | Release date: | 2022-11-09 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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8EUO
| Hydroxynitrile Lyase from Hevea brasiliensis with Seven Mutations | Descriptor: | (S)-hydroxynitrile lyase | Authors: | Greenberg, L.R, Walsh, M.E, Kazlauskas, R.J, Pierce, C.T, Shi, K, Aihara, H, Evans, R.L. | Deposit date: | 2022-10-19 | Release date: | 2022-11-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | to be published To Be Published
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