8DNY

Cryo-EM structure of the human Sec61 complex inhibited by decatransin

Summary for 8DNY

Entry DOI	10.2210/pdb8dny/pdb
EMDB information	27584
Descriptor	Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit gamma, Protein transport protein Sec61 subunit beta, ... (4 entities in total)
Functional Keywords	translocon, decatransin, inhibitor, protein translocation, protein transport, protein transport-inhibitor complex, protein transport/inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	71144.83
Authors	Park, E.,Itskanov, S. (deposition date: 2022-07-12, release date: 2023-05-24, Last modification date: 2023-11-15)
Primary citation	Itskanov, S.,Wang, L.,Junne, T.,Sherriff, R.,Xiao, L.,Blanchard, N.,Shi, W.Q.,Forsyth, C.,Hoepfner, D.,Spiess, M.,Park, E. A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19:1063-1071, 2023 Cited by PubMed: 37169959 DOI: 10.1038/s41589-023-01337-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.85 Å)

Structure validation