3QX3
 
 | | Human topoisomerase IIbeta in complex with DNA and etoposide | | Descriptor: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... | | Authors: | Wu, C.C, Li, T.K, Farh, L, Lin, L.Y, Lin, T.S, Yu, Y.J, Yen, T.J, Chiang, C.W, Chan, N.L. | | Deposit date: | 2011-03-01 | | Release date: | 2011-07-06 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.162 Å) | | Cite: | Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide
Science, 333, 2011
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3QZS
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3QHT
 | | Crystal Structure of the Monobody ySMB-1 bound to yeast SUMO | | Descriptor: | GLYCEROL, Monobody ySMB-1, Ubiquitin-like protein SMT3 | | Authors: | Koide, S, Gilbreth, R.N. | | Deposit date: | 2011-01-26 | | Release date: | 2011-05-11 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3RAY
 | | Crystal structure of Methyltransferase domain of human PR domain-containing protein 11 | | Descriptor: | CHLORIDE ION, PR domain-containing protein 11, SODIUM ION, ... | | Authors: | Dong, A, Zeng, H, Loppnau, P, Walker, J.R, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2011-03-28 | | Release date: | 2011-04-20 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Crystal structure of Methyltransferase domain of human PR domain-containing protein 11
To be Published
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3R45
 | | Structure of a CENP-A-Histone H4 Heterodimer in complex with chaperone HJURP | | Descriptor: | GLYCEROL, Histone H3-like centromeric protein A, Histone H4, ... | | Authors: | Hu, H, Liu, Y, Wang, M, Fang, J, Huang, H, Yang, N, Li, Y, Wang, J, Yao, X, Shi, Y, Li, G, Xu, R.M. | | Deposit date: | 2011-03-17 | | Release date: | 2011-04-06 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP
Genes Dev., 25, 2011
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3RZ9
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3S4R
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3ODE
 | | Human PARP-1 zinc finger 2 (Zn2) bound to DNA | | Descriptor: | 5'-D(*CP*CP*CP*AP*AP*GP*CP*G)-3', 5'-D(*CP*GP*CP*TP*TP*GP*GP*G)-3', Poly [ADP-ribose] polymerase 1, ... | | Authors: | Pascal, J.M, Langelier, M.-F. | | Deposit date: | 2010-08-11 | | Release date: | 2011-01-12 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY.
J.Biol.Chem., 286, 2011
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3ODC
 | | Human PARP-1 zinc finger 2 (Zn2) bound to DNA | | Descriptor: | 5'-D(*CP*CP*CP*AP*GP*AP*CP*G)-3', 5'-D(*CP*GP*TP*CP*TP*GP*GP*G)-3', Poly [ADP-ribose] polymerase 1, ... | | Authors: | Pascal, J.M, Langelier, M.-F. | | Deposit date: | 2010-08-11 | | Release date: | 2011-01-12 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY.
J.Biol.Chem., 286, 2011
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3SDE
 | | Crystal structure of a paraspeckle-protein heterodimer, PSPC1/NONO | | Descriptor: | 1,2-ETHANEDIOL, Non-POU domain-containing octamer-binding protein, Paraspeckle component 1 | | Authors: | Passon, D.M, Lee, M, Bond, C.S. | | Deposit date: | 2011-06-09 | | Release date: | 2012-03-14 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation.
Proc.Natl.Acad.Sci.USA, 109, 2012
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3BQO
 | | Crystal Structure of TRF1 TRFH domain and TIN2 peptide complex | | Descriptor: | TERF1-interacting nuclear factor 2, Telomeric repeat-binding factor 1 | | Authors: | Chen, Y, Yang, Y, van Overbeek, M, Donigian, J.R, Baciu, P, de Lange, T, Lei, M. | | Deposit date: | 2007-12-20 | | Release date: | 2008-02-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
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3C5R
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2QUV
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2QUU
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3CH5
 | | The crystal structure of the RanGDP-Nup153ZnF2 complex | | Descriptor: | Fragment of Nuclear pore complex protein Nup153, GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Vetter, I.R, Schrader, N. | | Deposit date: | 2008-03-07 | | Release date: | 2008-07-01 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The Crystal Structure of the Ran-Nup153ZnF2 Complex: a General Ran Docking Site at the Nuclear Pore Complex
Structure, 16, 2008
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2QZV
 | | Draft Crystal Structure of the Vault Shell at 9 Angstroms Resolution | | Descriptor: | Major vault protein | | Authors: | Anderson, D.H, Kickhoefer, V.A, Sievers, S.A, Rome, L.H, Eisenberg, D. | | Deposit date: | 2007-08-17 | | Release date: | 2007-12-04 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (9 Å) | | Cite: | Draft crystal structure of the vault shell at 9-A resolution.
Plos Biol., 5, 2007
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1WXP
 | | Solution structure of the death domain of nuclear matrix protein p84 | | Descriptor: | THO complex subunit 1 | | Authors: | Niraula, T.N, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-01-28 | | Release date: | 2005-07-28 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the death domain of nuclear matrix protein p84
To be Published
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1TGZ
 | | Structure of human Senp2 in complex with SUMO-1 | | Descriptor: | SULFATE ION, Sentrin-specific protease 2, Ubiquitin-like protein SMT3C | | Authors: | Reverter, D, Lima, C.D. | | Deposit date: | 2004-05-31 | | Release date: | 2004-09-14 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | A basis for SUMO protease specificity provided by analysis of human Senp2 and a
Senp2-SUMO complex
Structure, 12, 2004
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1WF1
 | | Solution structure of RRM domain in RNA-binding protein NP_057951 | | Descriptor: | RNA-binding protein Raly | | Authors: | He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2004-05-25 | | Release date: | 2004-11-25 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of RRM domain in RNA-binding protein NP_057951
To be Published
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1X5P
 | | Solution structure of RRM domain in Parp14 | | Descriptor: | Negative elongation factor E | | Authors: | Dang, W, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-05-16 | | Release date: | 2005-11-16 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of RRM domain in Parp14
To be Published
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1R49
 | | Human topoisomerase I (Topo70) double mutant K532R/Y723F | | Descriptor: | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(P*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I | | Authors: | Interthal, H, Quigley, P.M, Hol, W.G, Champoux, J.J. | | Deposit date: | 2003-10-03 | | Release date: | 2003-12-16 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.13 Å) | | Cite: | The role of lysine 532 in the catalytic mechanism of human topoisomerase I.
J.Biol.Chem., 279, 2004
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1X4F
 | | Solution structure of the second RRM domain in Matrin 3 | | Descriptor: | Matrin 3 | | Authors: | He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-05-14 | | Release date: | 2005-11-14 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the second RRM domain in Matrin 3
To be Published
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1SEU
 | | Human DNA Topoisomerase I (70 Kda) In Complex With The Indolocarbazole SA315F and Covalent Complex With A 22 Base Pair DNA Duplex | | Descriptor: | 2,10-DIHYDROXY-12-(BETA-D-GLUCOPYRANOSYL)-6,7,12,13-TETRAHYDROINDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7-DIONE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... | | Authors: | Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B. | | Deposit date: | 2004-02-18 | | Release date: | 2005-04-19 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
J.Med.Chem., 48, 2005
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1T5A
 | | Human Pyruvate Kinase M2 | | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Dombrauckas, J.D, Santarsiero, B.D, Mesecar, A.D. | | Deposit date: | 2004-05-03 | | Release date: | 2005-07-12 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.
Biochemistry, 44, 2005
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1UFG
 | | Solution structure of immunoglobulin like domain of mouse nuclear lamin | | Descriptor: | Lamin A | | Authors: | Kobayashi, N, Kigawa, T, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2003-05-29 | | Release date: | 2004-06-22 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Solution structure of immunoglobulin like domain of mouse nuclear lamin
To be Published
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