1SJV
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![BU of 1sjv by Molmil](/molmil-images/mine/1sjv) | Three-Dimensional Structure of a Llama VHH Domain Swapping | Descriptor: | r9 | Authors: | Spinelli, S, Desmyter, A, Frenken, L, Verrips, T, Cambillau, C. | Deposit date: | 2004-03-04 | Release date: | 2004-06-01 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Domain swapping of a llama VHH domain builds a crystal-wide beta-sheet structure. Febs Lett., 564, 2004
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1JGL
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![BU of 1jgl by Molmil](/molmil-images/mine/1jgl) | |
7S83
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![BU of 7s83 by Molmil](/molmil-images/mine/7s83) | Crystal structure of SARS CoV-2 Spike Receptor Binding Domain in complex with shark neutralizing VNARs ShAb01 and ShAb02 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ShAb01 VNAR, ... | Authors: | Chen, W.-H, Hajduczki, A, Dooley, H.M, Joyce, M.G. | Deposit date: | 2021-09-17 | Release date: | 2022-11-23 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity. Nat Commun, 14, 2023
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8FQ7
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![BU of 8fq7 by Molmil](/molmil-images/mine/8fq7) | Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils | Descriptor: | GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils | Authors: | Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S. | Deposit date: | 2023-01-05 | Release date: | 2023-10-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc.Natl.Acad.Sci.USA, 120, 2023
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8IDN
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![BU of 8idn by Molmil](/molmil-images/mine/8idn) | Cryo-EM structure of RBD/E77-Fab complex | Descriptor: | E77 Fab heavy chain, E77 Fab light chain, Spike protein S1, ... | Authors: | Lu, D.F, Zhang, Z.C. | Deposit date: | 2023-02-13 | Release date: | 2023-06-21 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | The structure of the RBD-E77 Fab complex reveals neutralization and immune escape of SARS-CoV-2. Acta Crystallogr D Struct Biol, 79, 2023
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8DMJ
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6IC3
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![BU of 6ic3 by Molmil](/molmil-images/mine/6ic3) | AL amyloid fibril from a lambda 1 light chain | Descriptor: | lambda 1 light chain fragment, residues 3-118 | Authors: | Fritz, G, Faendrich, M, Schmidt, M, Radamaker, L. | Deposit date: | 2018-12-02 | Release date: | 2019-04-03 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis. Nat Commun, 10, 2019
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4M48
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![BU of 4m48 by Molmil](/molmil-images/mine/4m48) | X-ray structure of dopamine transporter elucidates antidepressant mechanism | Descriptor: | 9D5 antibody, heavy chain, light chain, ... | Authors: | Gouaux, E, Penmatsa, A, Wang, K. | Deposit date: | 2013-08-06 | Release date: | 2013-09-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.955 Å) | Cite: | X-ray structure of dopamine transporter elucidates antidepressant mechanism. Nature, 503, 2013
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7RSO
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![BU of 7rso by Molmil](/molmil-images/mine/7rso) | AMC016 SOSIP.v4.2 in complex with PGV04 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AMC016 gp120, ... | Authors: | Bader, D.L.V, Cottrell, C.A, Ward, A.B. | Deposit date: | 2021-08-11 | Release date: | 2021-09-15 | Last modified: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | The Glycan Hole Area of HIV-1 Envelope Trimers Contributes Prominently to the Induction of Autologous Neutralization. J.Virol., 96, 2022
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7RSN
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![BU of 7rsn by Molmil](/molmil-images/mine/7rsn) | AMC018 SOSIP.v4.2 in complex with PGV04 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AMC018 gp120, ... | Authors: | Cottrell, C.A, Ward, A.B. | Deposit date: | 2021-08-11 | Release date: | 2021-09-15 | Last modified: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | The Glycan Hole Area of HIV-1 Envelope Trimers Contributes Prominently to the Induction of Autologous Neutralization. J.Virol., 96, 2022
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8PE9
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![BU of 8pe9 by Molmil](/molmil-images/mine/8pe9) | Complex between DDR1 DS-like domain and PRTH-101 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Liu, J, Chiang, H, Xiong, W, Laurent, V, Griffiths, S.C, Duelfer, J, Deng, H, Sun, X, Yin, Y.W, Li, W, Audoly, L.P, An, Z, Schuerpf, T, Li, R, Zhang, N. | Deposit date: | 2023-06-13 | Release date: | 2023-06-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.152 Å) | Cite: | A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer. J Immunother Cancer, 11, 2023
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3QO1
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![BU of 3qo1 by Molmil](/molmil-images/mine/3qo1) | Monoclinic form of IgG1 Fab fragment (apo form) sharing same Fv as IgA | Descriptor: | Fab fragment of IMMUNOGLOBULIN G1 HEAVY CHAIN, Fab fragment of IMMUNOGLOBULIN G1 LIGHT CHAIN, GLYCEROL | Authors: | Trajtenberg, F, Correa, A, Buschiazzo, A. | Deposit date: | 2011-02-09 | Release date: | 2012-02-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of a human IgA1 Fab fragment at 1.55 angstrom resolution: potential effect of the constant domains on antigen-affinity modulation Acta Crystallogr.,Sect.D, 69, 2013
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4OGA
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5VN8
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![BU of 5vn8 by Molmil](/molmil-images/mine/5vn8) | Cryo-EM model of B41 SOSIP.664 in complex with fragment antigen binding variable domain of b12 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | Authors: | Ozorowski, G, Pallesen, J, Ward, A.B, Cottrell, C.A. | Deposit date: | 2017-04-28 | Release date: | 2017-07-12 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike. Nature, 547, 2017
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6T9D
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![BU of 6t9d by Molmil](/molmil-images/mine/6t9d) | Crystal structure of a bispecific DutaFab in complex with human VEGF121 | Descriptor: | VP mat DutaFab VH chain, VP mat DutaFab VL chain, Vascular endothelial growth factor A | Authors: | Kimbung, R, Logan, D.T, Beckmann, R, Jensen, K, Speck, J, Fenn, S, Kettenberger, H. | Deposit date: | 2019-10-28 | Release date: | 2020-12-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.905 Å) | Cite: | DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously. Nat Commun, 12, 2021
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2QL1
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![BU of 2ql1 by Molmil](/molmil-images/mine/2ql1) | Structural Characterization of a Mutated, ADCC-Enhanced Human Fc Fragment | Descriptor: | IGHM protein, ZINC ION, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Oganesyan, V, Wu, H, Dall'Acqua, W.F. | Deposit date: | 2007-07-12 | Release date: | 2008-04-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.534 Å) | Cite: | Structural characterization of a mutated, ADCC-enhanced human Fc fragment Mol.Immunol., 45, 2008
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6KS0
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![BU of 6ks0 by Molmil](/molmil-images/mine/6ks0) | Crystal structure of the human adiponectin receptor 1 | Descriptor: | Adiponectin receptor protein 1, PHOSPHATE ION, The heavy chain variable domain (Antibody), ... | Authors: | Tanabe, H, Fujii, Y, Nakamura, Y, Hosaka, T, Okada-Iwabu, M, Iwabu, M, Kimura-Someya, T, Shirouzu, M, Yamauchi, T, Kadowaki, T, Yokoyama, S. | Deposit date: | 2019-08-22 | Release date: | 2020-08-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Human adiponectin receptor AdipoR1 assumes closed and open structures. Commun Biol, 3, 2020
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4BFB
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![BU of 4bfb by Molmil](/molmil-images/mine/4bfb) | BACE2 XAPERONE COMPLEX | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-SECRETASE 2, XA4813 | Authors: | Banner, D.W, Kuglstatter, A, Benz, J, Stihle, M, Ruf, A. | Deposit date: | 2013-03-18 | Release date: | 2013-05-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Mapping the Conformational Space Accessible to Bace2 Using Surface Mutants and Co-Crystals with Fab-Fragments, Fynomers, and Xaperones Acta Crystallogr.,Sect.D, 69, 2013
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6KS1
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![BU of 6ks1 by Molmil](/molmil-images/mine/6ks1) | Crystal structure of the human adiponectin receptor 2 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, ... | Authors: | Tanabe, H, Fujii, Y, Nakamura, Y, Hosaka, T, Okada-Iwabu, M, Iwabu, M, Kimura-Someya, T, Shirouzu, M, Yamauchi, T, Kadowaki, T, Yokoyama, S. | Deposit date: | 2019-08-22 | Release date: | 2020-08-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Human adiponectin receptor AdipoR1 assumes closed and open structures. Commun Biol, 3, 2020
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6KRZ
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![BU of 6krz by Molmil](/molmil-images/mine/6krz) | Crystal structure of the human adiponectin receptor 1 D208A mutant | Descriptor: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Adiponectin receptor protein 1, OLEIC ACID, ... | Authors: | Tanabe, H, Fujii, Y, Okada-Iwabu, M, Iwabu, M, Yamauchi, T, Kadowaki, T, Yokoyama, S. | Deposit date: | 2019-08-22 | Release date: | 2020-08-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Human adiponectin receptor AdipoR1 assumes closed and open structures. Commun Biol, 3, 2020
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4BEL
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![BU of 4bel by Molmil](/molmil-images/mine/4bel) | BACE2 XAPERONE COMPLEX | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-SECRETASE 2, CHLORIDE ION, ... | Authors: | Banner, D.W, Kuglstatter, A, Benz, J, Stihle, M, Ruf, A. | Deposit date: | 2013-03-11 | Release date: | 2013-05-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Mapping the Conformational Space Accessible to Bace2 Using Surface Mutants and Co-Crystals with Fab-Fragments, Fynomers, and Xaperones Acta Crystallogr.,Sect.D, 69, 2013
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3ZKQ
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![BU of 3zkq by Molmil](/molmil-images/mine/3zkq) | BACE2 XAPERONE COMPLEX | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-SECRETASE 2, CHLORIDE ION, ... | Authors: | Banner, D.W, Kuglstatter, A, Benz, J, Stihle, M, Ruf, A. | Deposit date: | 2013-01-24 | Release date: | 2013-05-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Mapping the Conformational Space Accessible to Bace2 Using Surface Mutants and Co-Crystals with Fab-Fragments, Fynomers, and Xaperones Acta Crystallogr.,Sect.D, 69, 2013
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6T9E
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![BU of 6t9e by Molmil](/molmil-images/mine/6t9e) | Crystal structure of a bispecific DutaFab in complex with human PDGF | Descriptor: | DutaFab mat VH chain, DutaFab mat VL chain, Platelet-derived growth factor subunit B | Authors: | Kimbung, R, Logan, D.T, Beckmann, R, Jensen, K, Speck, J, Fenn, S, Kettenberger, H. | Deposit date: | 2019-10-28 | Release date: | 2020-12-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.989 Å) | Cite: | DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously. Nat Commun, 12, 2021
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4D3C
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4DKA
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![BU of 4dka by Molmil](/molmil-images/mine/4dka) | Structure of Editosome protein | Descriptor: | RNA-editing complex protein MP81, SODIUM ION, single domain antibody VHH | Authors: | Park, Y.-J, Hol, W. | Deposit date: | 2012-02-03 | Release date: | 2012-07-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2. Nucleic Acids Res., 40, 2012
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