8PE9

Complex between DDR1 DS-like domain and PRTH-101 Fab

Summary for 8PE9

• Entry DOI: 10.2210/pdb8pe9/pdb
• Descriptor: Epithelial discoidin domain-containing receptor 1, PRTH-101 Fab, heavy chain, PRTH-101 Fab, light chain, ... (8 entities in total)
• Functional Keywords: humanized antibody, ddr1, collagen, immune exclusion, breast cancer, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 68074.07

Authors

Liu, J.,Chiang, H.,Xiong, W.,Laurent, V.,Griffiths, S.C.,Duelfer, J.,Deng, H.,Sun, X.,Yin, Y.W.,Li, W.,Audoly, L.P.,An, Z.,Schuerpf, T.,Li, R.,Zhang, N. (deposition date: 2023-06-13, release date: 2023-06-28, Last modification date: 2024-11-20)

Primary citation

Liu, J.,Chiang, H.C.,Xiong, W.,Laurent, V.,Griffiths, S.C.,Dulfer, J.,Deng, H.,Sun, X.,Yin, Y.W.,Li, W.,Audoly, L.P.,An, Z.,Schurpf, T.,Li, R.,Zhang, N.
A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer.
J Immunother Cancer, 11:-, 2023

PubMed Abstract: Immune exclusion (IE) where tumors deter the infiltration of immune cells into the tumor microenvironment has emerged as a key mechanism underlying immunotherapy resistance. We recently reported a novel role of discoidin domain-containing receptor 1 (DDR1) in promoting IE in breast cancer and validated its critical role in IE using neutralizing rabbit monoclonal antibodies (mAbs) in multiple mouse tumor models.

PubMed: 37328286
DOI: 10.1136/jitc-2023-006720

Experimental method

X-RAY DIFFRACTION (3.152 Å)