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1MSW
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BU of 1msw by Molmil
Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase
Descriptor: DNA-directed RNA polymerase, Non-Template DNA, RNA message, ...
Authors:Yin, Y.W, Steitz, T.A.
Deposit date:2002-09-19
Release date:2002-11-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for the Transition from Initiation to Elongation Transcription in T7 RNA Polymerase
Science, 298, 2002
1S77
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BU of 1s77 by Molmil
T7 RNAP product pyrophosphate elongation complex
Descriptor: DNA (5'-D(*GP*CP*CP*GP*TP*GP*CP*GP*CP*AP*TP*TP*CP*GP*CP*CP*GP*TP*GP*TP*T)-3'), DNA (5'-D(*TP*TP*TP*AP*CP*GP*TP*TP*GP*CP*GP*CP*AP*CP*GP*GP*C)-3'), DNA-directed RNA polymerase, ...
Authors:Yin, Y.W, Steitz, T.A.
Deposit date:2004-01-29
Release date:2004-03-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:The structural mechanism of translocation and helicase activity in T7 RNA polymerase.
Cell(Cambridge,Mass.), 116, 2004
1S76
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BU of 1s76 by Molmil
T7 RNA polymerase alpha beta methylene ATP elongation complex
Descriptor: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA (5'-D(P*GP*CP*CP*GP*TP*GP*CP*GP*CP*AP*TP*TP*CP*GP*CP*CP*GP*TP*GP*TP*T)-3'), DNA (5'-D(P*TP*TP*TP*AP*CP*GP*TP*TP*GP*CP*GP*CP*AP*CP*GP*GP*C)-3'), ...
Authors:Yin, Y.W, Steitz, T.A.
Deposit date:2004-01-29
Release date:2004-03-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:The structural mechanism of translocation and helicase activity in T7 RNA polymerase.
Cell(Cambridge,Mass.), 116, 2004
4MKW
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BU of 4mkw by Molmil
Comparison of the structural and dynamic effects of 5-methylcytosine and 5-chlorocytosine in a CpG dinucleotide sequence
Descriptor: 5methylC DNA dodecamer, MAGNESIUM ION
Authors:Yin, Y.W.
Deposit date:2013-09-05
Release date:2013-11-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.219 Å)
Cite:Comparison of the structural and dynamic effects of 5-methylcytosine and 5-chlorocytosine in a CpG dinucleotide sequence.
Biochemistry, 52, 2013
8D3R
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BU of 8d3r by Molmil
Human mitochondrial DNA polymerase gamma ternary complex with GT basepair in intermediate conformer
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*AP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*TP*AP*T)-3'), ...
Authors:Park, J, Yin, Y.W.
Deposit date:2022-06-01
Release date:2023-05-24
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Pol gamma coordinates DNA synthesis and proofreading to ensure mitochondrial genome integrity.
Nat.Struct.Mol.Biol., 30, 2023
8D33
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BU of 8d33 by Molmil
Human mitochondrial DNA polymerase gamma ternary complex with GC basepair
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (25-MER), ...
Authors:Park, J, Yin, Y.W.
Deposit date:2022-05-31
Release date:2023-05-24
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (2.46 Å)
Cite:Pol gamma coordinates DNA synthesis and proofreading to ensure mitochondrial genome integrity.
Nat.Struct.Mol.Biol., 30, 2023
8D42
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BU of 8d42 by Molmil
Human mitochondrial DNA polymerase gamma ternary complex with GT basepair in editing conformer (composite)
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*TP*AP*T)-3'), ...
Authors:Park, J, Yin, Y.W.
Deposit date:2022-06-01
Release date:2023-05-24
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (2.91 Å)
Cite:Pol gamma coordinates DNA synthesis and proofreading to ensure mitochondrial genome integrity.
Nat.Struct.Mol.Biol., 30, 2023
8D37
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BU of 8d37 by Molmil
Human mitochondrial DNA polymerase gamma ternary complex with GT basepair in replication conformer
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (25-MER), ...
Authors:Park, J, Yin, Y.W.
Deposit date:2022-05-31
Release date:2023-05-24
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (2.65 Å)
Cite:Pol gamma coordinates DNA synthesis and proofreading to ensure mitochondrial genome integrity.
Nat.Struct.Mol.Biol., 30, 2023
7R6V
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BU of 7r6v by Molmil
Human EXOG complexed with dRP-containing DNA
Descriptor: DNA (5'-D(*CP*GP*CP*AP*CP*GP*TP*CP*AP*GP*AP*A)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*GP*TP*GP*CP*G)-3'), MAGNESIUM ION, ...
Authors:Szymanski, M.R, Yin, Y.W.
Deposit date:2021-06-23
Release date:2022-08-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Human EXOG possesses strong AP hydrolysis activity
To Be Published
2PI5
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BU of 2pi5 by Molmil
T7 RNA polymerase complexed with a phi10 promoter
Descriptor: 5'-D(*CP*TP*TP*C*CP*TP*AP*TP*AP*GP*TP*GP*AP*GP*TP*CP*GP*TP*AP*TP*TP*A)-3', 5'-D(*TP*AP*AP*TP*AP*CP*GP*AP*CP*TP*CP*AP*CP*T)-3', DNA-directed RNA polymerase
Authors:Kennedy, W.P, Momand, J.R, Yin, Y.W.
Deposit date:2007-04-12
Release date:2007-06-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Mechanism for de novo RNA synthesis and initiating nucleotide specificity by t7 RNA polymerase.
J.Mol.Biol., 370, 2007
2PI4
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BU of 2pi4 by Molmil
T7RNAP complexed with a phi10 protein and initiating GTPs.
Descriptor: 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*TP*CP*CP*TP*AP*TP*AP*GP*TP*GP*AP*GP*TP*CP*GP*TP*AP*TP*TP*A)-3', 5'-D(*TP*AP*AP*TP*AP*CP*GP*AP*CP*TP*CP*AP*CP*T)-3', ...
Authors:Kennedy, W.P, Momand, J.R, Yin, Y.W.
Deposit date:2007-04-12
Release date:2007-06-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanism for de novo RNA synthesis and initiating nucleotide specificity by t7 RNA polymerase.
J.Mol.Biol., 370, 2007
4ZTU
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BU of 4ztu by Molmil
Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase
Descriptor: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*AP*AP*GP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), ...
Authors:Szymanski, M.R, Kuznestov, V.B, Shumate, C.K, Meng, Q, Lee, Y.-S, Patel, G, Patel, S.S, Yin, Y.W.
Deposit date:2015-05-15
Release date:2015-09-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.299 Å)
Cite:Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase
EMBO J., 34, 2015
4ZTZ
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BU of 4ztz by Molmil
Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*AP*AP*GP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), ...
Authors:Szymanski, M.R, Yin, Y.W.
Deposit date:2015-05-15
Release date:2015-09-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.442 Å)
Cite:Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase
EMBO J., 34, 2015
7R6T
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BU of 7r6t by Molmil
Human EXOG complexed with dRP-containing DNA
Descriptor: DNA (5'-D(*CP*GP*CP*AP*CP*GP*TP*CP*AP*GP*A)-3'), DNA (5'-D(3DR)P*CP*TP*GP*AP*CP*GP*TP*GP*C)-3'), MAGNESIUM ION, ...
Authors:Szymanski, M.R, Yin, Y.W.
Deposit date:2021-06-23
Release date:2022-08-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Human EXOG possesses strong AP hydrolysis activity
To Be Published
3IKL
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BU of 3ikl by Molmil
Crystal structure of Pol gB delta-I4.
Descriptor: DNA polymerase subunit gamma-2, mitochondrial
Authors:Lee, Y.S, Kennedy, W.D, Yin, Y.W.
Deposit date:2009-08-06
Release date:2010-08-25
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations.
Cell(Cambridge,Mass.), 139, 2009
3IKM
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BU of 3ikm by Molmil
Crystal structure of human mitochondrial DNA polymerase holoenzyme
Descriptor: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2
Authors:Lee, Y.-S, Kennedy, W.D, Yin, Y.W.
Deposit date:2009-08-06
Release date:2009-11-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations.
Cell(Cambridge,Mass.), 139, 2009
5C52
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BU of 5c52 by Molmil
Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma
Descriptor: DNA (26-MER), DNA (5'-D(*AP*AP*AP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), DNA polymerase subunit gamma-1, ...
Authors:Sohl, C.D, Szymanski, M.R, Mislak, A.C, Shumate, C.K, Amiralaei, S, Schinazi, R.F, Anderson, K.S, Yin, Y.W.
Deposit date:2015-06-19
Release date:2016-05-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.637 Å)
Cite:Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma.
Proc.Natl.Acad.Sci.USA, 112, 2015
5C53
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BU of 5c53 by Molmil
Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma
Descriptor: 2',3'-DIDEOXYCYTIDINE-5'-MONOPHOSPHATE, DNA (26-MER), DNA (5'-D(*AP*AP*AP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), ...
Authors:Sohl, C.D, Szymanski, M.R, Mislak, A.C, Shumate, C.K, Amiralaei, S, Schinazi, R.F, Anderson, K.S, Yin, Y.W.
Deposit date:2015-06-19
Release date:2016-01-27
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.567 Å)
Cite:Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma.
Proc.Natl.Acad.Sci.USA, 112, 2015
8PE9
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BU of 8pe9 by Molmil
Complex between DDR1 DS-like domain and PRTH-101 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Liu, J, Chiang, H, Xiong, W, Laurent, V, Griffiths, S.C, Duelfer, J, Deng, H, Sun, X, Yin, Y.W, Li, W, Audoly, L.P, An, Z, Schuerpf, T, Li, R, Zhang, N.
Deposit date:2023-06-13
Release date:2023-06-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.152 Å)
Cite:A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer.
J Immunother Cancer, 11, 2023
6OUN
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BU of 6oun by Molmil
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)3TC-TP
Descriptor: DNA primer 20-mer, DNA template 27-mer, Lamivudine Triphosphate, ...
Authors:Bertoletti, N, Anderson, K.S.
Deposit date:2019-05-04
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.656 Å)
Cite:Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci., 28, 2019
6OTZ
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BU of 6otz by Molmil
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (+)FTC-TP
Descriptor: DNA Primer 20-mer, DNA template 27-mer, GLYCEROL, ...
Authors:Bertoletti, N, Anderson, K.S.
Deposit date:2019-05-03
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.857 Å)
Cite:Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci., 28, 2019
6P2G
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BU of 6p2g by Molmil
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and D-ddCTP
Descriptor: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA Primer 20-mer, DNA template 27-mer, ...
Authors:Bertoletti, N, Anderson, K.S.
Deposit date:2019-05-21
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci., 28, 2019
6P1I
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BU of 6p1i by Molmil
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and dCTP
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA Primer 20-mer, DNA template 27-mer, ...
Authors:Bertoletti, N, Anderson, K.S.
Deposit date:2019-05-19
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci., 28, 2019
6P1X
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BU of 6p1x by Molmil
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and L-ddCTP
Descriptor: DNA Primer 20-mer, DNA template 27-mer, MAGNESIUM ION, ...
Authors:Bertoletti, N, Anderson, K.S.
Deposit date:2019-05-20
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.553 Å)
Cite:Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci., 28, 2019
5T4I
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BU of 5t4i by Molmil
A Novel domain in human EXOG converts apoptotic endonuclease to DNA-repair enzyme
Descriptor: DNA (5'-D(*GP*CP*AP*CP*GP*TP*CP*AP*G)-3'), DNA (5'-D(P*CP*TP*GP*AP*CP*GP*TP*GP*C)-3'), MANGANESE (II) ION, ...
Authors:Szymanski, M.R, Yin, W.Y.
Deposit date:2016-08-29
Release date:2017-05-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.389 Å)
Cite:A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease.
Nat Commun, 8, 2017

 

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