4BFB

BACE2 XAPERONE COMPLEX

Summary for 4BFB

Entry DOI	10.2210/pdb4bfb/pdb
Related	3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZOV 4BEK 4BEL
Descriptor	BETA-SECRETASE 2, XA4813, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
Functional Keywords	hydrolase-immune system complex, nanobody, hydrolase/immune system
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Membrane; Single-pass type I membrane protein: Q9Y5Z0
Total number of polymer chains	4
Total formula weight	110798.16
Authors	Banner, D.W.,Kuglstatter, A.,Benz, J.,Stihle, M.,Ruf, A. (deposition date: 2013-03-18, release date: 2013-05-29, Last modification date: 2023-12-20)
Primary citation	Banner, D.W.,Gsell, B.,Benz, J.,Bertschinger, J.,Burger, D.,Brack, S.,Cuppuleri, S.,Debulpaep, M.,Gast, A.,Grabulovski, D.,Hennig, M.,Hilpert, H.,Huber, W.,Kuglstatter, A.,Kusznir, E.,Laeremans, T.,Matile, H.,Miscenic, C.,Rufer, A.,Schlatter, D.,Steyeart, J.,Stihle, M.,Thoma, R.,Weber, M.,Ruf, A. Mapping the Conformational Space Accessible to Bace2 Using Surface Mutants and Co-Crystals with Fab-Fragments, Fynomers, and Xaperones Acta Crystallogr.,Sect.D, 69:1124-, 2013 Cited by PubMed: 23695257 DOI: 10.1107/S0907444913006574 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.21 Å)

Structure validation