PDB: 663 resultsInfo pagesStatus searchChemie searchBIRD

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3QXM	Crystal Structure of Human GluK2 Ligand-Binding Core in Complex with Novel Marine-Derived Toxins, Neodysiherbaine A Descriptor: (2R,3aR,6R,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6,7-dihydroxyhexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, Glutamate receptor ionotropic, kainate 2 Authors: Unno, M, Sasaki, M, Ikeda-Saito, M. Deposit date: 2011-03-02 Release date: 2011-10-26 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
3PMX	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... Authors: Maclean, J.K.F, Jamieson, C, Brown, C.I, Campbell, R.A, Gillen, K.J, Gillespie, J, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. Deposit date: 2010-11-18 Release date: 2011-01-12 Last modified: 2017-08-09 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg.Med.Chem.Lett., 21, 2011
3PMV	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Descriptor: GLUTAMIC ACID, GLYCEROL, Glutamate receptor 2, ... Authors: Maclean, J.K.F, Jamieson, C, Brown, C.I, Campbell, R.A, Gillen, K.J, Gillespie, J, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. Deposit date: 2010-11-18 Release date: 2011-01-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg.Med.Chem.Lett., 21, 2011
3O29	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Descriptor: GLUTAMIC ACID, GLYCEROL, Glutamate receptor 2, ... Authors: Maclean, J.K.F, Basten, S, Campbell, R.A, Cumming, I.A, Gillen, K.J, Gillespie, J, Jamieson, C, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Papakosta, M, Rankovic, Z, Smith, L. Deposit date: 2010-07-22 Release date: 2010-09-15 Last modified: 2017-08-09 Method: X-RAY DIFFRACTION (2.02 Å) Cite: A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies. Bioorg.Med.Chem.Lett., 20, 2010
3O28	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Descriptor: 2-({[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... Authors: Maclean, J.K.F, Basten, S, Campbell, R.A, Cumming, I.A, Gillen, K.J, Gillespie, J, Jamieson, C, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Papakosta, M, Rankovic, Z, Smith, L. Deposit date: 2010-07-22 Release date: 2010-09-15 Last modified: 2017-08-09 Method: X-RAY DIFFRACTION (2 Å) Cite: A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies. Bioorg.Med.Chem.Lett., 20, 2010
3RN8	Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator Descriptor: 3,3'-benzene-1,4-diylbis(4-cyano-5-ethylthiophene-2-carboxylic acid), ACETATE ION, GLUTAMIC ACID, ... Authors: Timm, D.E. Deposit date: 2011-04-22 Release date: 2011-05-25 Last modified: 2017-08-23 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol., 80, 2011
3RTF	Chlorowillardiine bound to the ligand binding domain of GluA2 Descriptor: 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2, ZINC ION Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2011-05-03 Release date: 2011-05-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3R7X	Crystal Structure Analysis of a Quinazolinedione sulfonamide bound to human GluR2: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity Descriptor: GLUTAMIC ACID, Glutamate receptor 2, N-[6-(1H-imidazol-1-yl)-7-nitro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]methanesulfonamide Authors: Kallen, J. Deposit date: 2011-03-23 Release date: 2011-05-18 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Quinazolinedione sulfonamides: A novel class of competitive AMPA receptor antagonists with oral activity. Bioorg.Med.Chem.Lett., 21, 2011
3RNN	Crystal Structure of iGluR2 Ligand Binding Domain with Symmetric Sulfonamide Containing Potentiator Descriptor: GLUTAMIC ACID, Glutamate receptor 2, N,N'-(benzene-1,4-diyldiethane-2,1-diyl)dipropane-2-sulfonamide, ... Authors: Timm, D.E. Deposit date: 2011-04-22 Release date: 2011-05-25 Last modified: 2019-07-17 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol., 80, 2011
3RT6	Fluorowillardiine bound to the ligand binding domain of GluA3 Descriptor: 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2011-05-03 Release date: 2011-05-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.836 Å) Cite: Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3RT8	Chlorowillardiine bound to the ligand binding domain of GluA3 Descriptor: 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 3, ZINC ION Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2011-05-03 Release date: 2011-05-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.426 Å) Cite: Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3OEL	Crystal structure of GluN2D ligand-binding core in complex with D-glutamate Descriptor: D-GLUTAMIC ACID, Glutamate [NMDA] receptor subunit epsilon-4 Authors: Simorowski, N, Furukawa, H. Deposit date: 2010-08-12 Release date: 2011-05-11 Last modified: 2017-08-23 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nat Commun, 2, 2011
3OEN	Crystal structure of GluN2D ligand-binding core in complex with L-glutamate Descriptor: GLUTAMIC ACID, Glutamate [NMDA] receptor subunit epsilon-4 Authors: Simorowski, N, Furukawa, H. Deposit date: 2010-08-12 Release date: 2011-05-11 Last modified: 2017-08-23 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nat Commun, 2, 2011
3OEK	Crystal structure of GluN2D ligand-binding core in complex with L-aspartate Descriptor: ASPARTIC ACID, Glutamate [NMDA] receptor subunit epsilon-4 Authors: Simorowski, N, Furukawa, H. Deposit date: 2010-08-12 Release date: 2011-05-11 Last modified: 2017-08-23 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nat Commun, 2, 2011
3RTW	Nitrowillardiine bound to the ligand binding domain of GluA2 Descriptor: 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2, ZINC ION Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2011-05-04 Release date: 2011-05-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.095 Å) Cite: Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
4TLL	Crystal structure of GluN1/GluN2B NMDA receptor, structure 1 Descriptor: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ... Authors: Gouaux, E, Lee, C.-H, Lu, W. Deposit date: 2014-05-30 Release date: 2014-07-02 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.59 Å) Cite: NMDA receptor structures reveal subunit arrangement and pore architecture. Nature, 511, 2014
4TLM	Crystal structure of GluN1/GluN2B NMDA receptor, structure 2 Descriptor: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ... Authors: Gouaux, E, Lee, C.-H, Lu, W. Deposit date: 2014-05-30 Release date: 2014-07-02 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.77 Å) Cite: NMDA receptor structures reveal subunit arrangement and pore architecture. Nature, 511, 2014
4U4G	Structure of GluA2* in complex with competitive antagonist ZK 200775 Descriptor: Glutamate receptor 2, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid Authors: Yelshanskaya, M.V, Li, M, Sobolevsky, A.I. Deposit date: 2014-07-23 Release date: 2014-10-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (4.49 Å) Cite: Structure of an agonist-bound ionotropic glutamate receptor. Science, 345, 2014
4U5B	Crystal structure of GluA2 A622T, con-ikot-ikot snail toxin, partial agonist KA and postitive modulator (R,R)-2b complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Con-ikot-ikot, ... Authors: Chen, L, Gouaux, E. Deposit date: 2014-07-25 Release date: 2014-08-13 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.5037 Å) Cite: X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism. Science, 345, 2014
4U5F	Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist KA and postitive modulator (R,R)-2b complex, GluA2cryst2 construct Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Con-ikot-ikot, ... Authors: Chen, L, Gouaux, E. Deposit date: 2014-07-24 Release date: 2014-08-13 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.7 Å) Cite: X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism. Science, 345, 2014
4U1W	Full length GluA2-kainate-(R,R)-2b complex crystal form A Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2, ... Authors: Chen, L, Gouaux, E. Deposit date: 2014-07-16 Release date: 2014-08-20 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
4U2P	Full-length AMPA subtype ionotropic glutamate receptor GluA2 in the apo state Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2 Authors: Duerr, K.L, Gouaux, E. Deposit date: 2014-07-17 Release date: 2014-08-20 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.2386 Å) Cite: Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
4U4F	Structure of GluA2* in complex with partial agonist (S)-5-Nitrowillardiine Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, ... Authors: Yelshanskaya, M.V, Li, M, Sobolevsky, A.I. Deposit date: 2014-07-23 Release date: 2014-08-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (4.79 Å) Cite: Structure of an agonist-bound ionotropic glutamate receptor. Science, 345, 2014
4U4S	Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM25 at 1.90 A resolution. Descriptor: 4-ethyl-3,4-dihydro-2H-pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide, ACETATE ION, CHLORIDE ION, ... Authors: Noerholm, A.B, Deva, T, Frydenvang, K, Kastrup, J.S. Deposit date: 2014-07-24 Release date: 2014-11-19 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides. J.Med.Chem., 57, 2014
4U4X	Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM37 at 1.56 A resolution. Descriptor: 4-ethyl-3,4-dihydro-2H-pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Noerholm, A.B, Frydenvang, K, Kastrup, J.S. Deposit date: 2014-07-24 Release date: 2014-11-19 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides. J.Med.Chem., 57, 2014

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