PDB: 688 resultsInfo pagesStatus searchChemie searchBIRD

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3O29	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Descriptor: GLUTAMIC ACID, GLYCEROL, Glutamate receptor 2, ... Authors: Maclean, J.K.F, Basten, S, Campbell, R.A, Cumming, I.A, Gillen, K.J, Gillespie, J, Jamieson, C, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Papakosta, M, Rankovic, Z, Smith, L. Deposit date: 2010-07-22 Release date: 2010-09-15 Last modified: 2017-08-09 Method: X-RAY DIFFRACTION (2.02 Å) Cite: A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies. Bioorg.Med.Chem.Lett., 20, 2010
3O28	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Descriptor: 2-({[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... Authors: Maclean, J.K.F, Basten, S, Campbell, R.A, Cumming, I.A, Gillen, K.J, Gillespie, J, Jamieson, C, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Papakosta, M, Rankovic, Z, Smith, L. Deposit date: 2010-07-22 Release date: 2010-09-15 Last modified: 2017-08-09 Method: X-RAY DIFFRACTION (2 Å) Cite: A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies. Bioorg.Med.Chem.Lett., 20, 2010
3QXM	Crystal Structure of Human GluK2 Ligand-Binding Core in Complex with Novel Marine-Derived Toxins, Neodysiherbaine A Descriptor: (2R,3aR,6R,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6,7-dihydroxyhexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, Glutamate receptor ionotropic, kainate 2 Authors: Unno, M, Sasaki, M, Ikeda-Saito, M. Deposit date: 2011-03-02 Release date: 2011-10-26 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
3B6Q	Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) Mutant T686A in Complex with Glutamate at 2.0 Resolution Descriptor: GLUTAMIC ACID, Glutamate receptor 2, SULFATE ION Authors: Cho, Y, Lolis, E, Howe, J.R. Deposit date: 2007-10-29 Release date: 2008-02-05 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating. J.Neurosci., 28, 2008
3B6W	Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686S Mutant in Complex with Glutamate at 1.7 Resolution Descriptor: GLUTAMIC ACID, Glutamate receptor 2, SULFATE ION Authors: Cho, Y, Lolis, E, Howe, J.R. Deposit date: 2007-10-29 Release date: 2008-02-05 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating. J.Neurosci., 28, 2008
3C33	Crystal structure of GluR5 ligand-binding core in complex with potassium at 1.78 Angstrom resolution Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... Authors: Mayer, M.L. Deposit date: 2008-01-27 Release date: 2008-06-17 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Molecular basis of kainate receptor modulation by sodium. Neuron, 58, 2008
3G3F	Crystal structure of the GluR6 ligand binding domain dimer with glutamate and NaCl at 1.38 Angstrom resolution Descriptor: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... Authors: Chaudhry, C, Mayer, M.L. Deposit date: 2009-02-02 Release date: 2009-06-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.377 Å) Cite: Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3FV2	Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with neodysiherbaine A in space group P1 Descriptor: (2R,3aR,6R,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6,7-dihydroxyhexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, GLYCEROL, Glutamate receptor, ... Authors: Unno, M, Sasaki, M, Ikeda-Saito, M. Deposit date: 2009-01-15 Release date: 2010-01-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
3C36	Crystal structure of GluR5 ligand-binding core in complex with ammonium ions at 1.68 Angstrom resolution Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, AMMONIUM ION, CHLORIDE ION, ... Authors: Mayer, M.L. Deposit date: 2008-01-27 Release date: 2008-06-17 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Molecular basis of kainate receptor modulation by sodium. Neuron, 58, 2008
3G3H	Crystal structure of the GluR6 ligand binding domain dimer K665R I749L Q753K mutant with glutamate and NaCl at 1.5 Angstrom resolution Descriptor: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... Authors: Chaudhry, C, Mayer, M.L. Deposit date: 2009-02-02 Release date: 2009-06-02 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3C34	Crystal structure of GluR5 ligand-binding core in complex with rubidium at 1.82 Angstrom resolution Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... Authors: Mayer, M.L. Deposit date: 2008-01-27 Release date: 2008-06-17 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Molecular basis of kainate receptor modulation by sodium. Neuron, 58, 2008
3G3K	Crystal structure of the GluR6 ligand binding domain dimer I442H K494E K665R I749L Q753K E757Q mutant with glutamate and NaCl at 1.24 Angstrom resolution Descriptor: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... Authors: Chaudhry, C, Mayer, M.L. Deposit date: 2009-02-02 Release date: 2009-06-02 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.24 Å) Cite: Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3FV1	Crystal Structure of the human glutamate receptor, GluR5, ligand-binding core in complex with dysiherbaine in space group P1 Descriptor: (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, GLYCEROL, Glutamate receptor, ... Authors: Unno, M, Sasaki, M, Ikeda-Saito, M. Deposit date: 2009-01-15 Release date: 2010-01-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
3O6H	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Descriptor: 1,2-ETHANEDIOL, 2-[({4-[(ethylamino)methyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}acetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, DIMETHYL SULFOXIDE, ... Authors: Maclean, J.K.F, Campbell, R.A, Cumming, I.A, Gillen, K.J, Gillespie, J, Jamieson, C, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Martin, F, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. Deposit date: 2010-07-29 Release date: 2010-09-15 Last modified: 2017-08-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A novel series of positive modulators of the AMPA receptor: structure-based lead optimization. Bioorg.Med.Chem.Lett., 20, 2010
3RN8	Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator Descriptor: 3,3'-benzene-1,4-diylbis(4-cyano-5-ethylthiophene-2-carboxylic acid), ACETATE ION, GLUTAMIC ACID, ... Authors: Timm, D.E. Deposit date: 2011-04-22 Release date: 2011-05-25 Last modified: 2017-08-23 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol., 80, 2011
3R7X	Crystal Structure Analysis of a Quinazolinedione sulfonamide bound to human GluR2: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity Descriptor: GLUTAMIC ACID, Glutamate receptor 2, N-[6-(1H-imidazol-1-yl)-7-nitro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]methanesulfonamide Authors: Kallen, J. Deposit date: 2011-03-23 Release date: 2011-05-18 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Quinazolinedione sulfonamides: A novel class of competitive AMPA receptor antagonists with oral activity. Bioorg.Med.Chem.Lett., 21, 2011
3RTF	Chlorowillardiine bound to the ligand binding domain of GluA2 Descriptor: 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2, ZINC ION Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2011-05-03 Release date: 2011-05-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3RNN	Crystal Structure of iGluR2 Ligand Binding Domain with Symmetric Sulfonamide Containing Potentiator Descriptor: GLUTAMIC ACID, Glutamate receptor 2, N,N'-(benzene-1,4-diyldiethane-2,1-diyl)dipropane-2-sulfonamide, ... Authors: Timm, D.E. Deposit date: 2011-04-22 Release date: 2011-05-25 Last modified: 2019-07-17 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol., 80, 2011
6JFY	GluK3 receptor trapped in Desensitized state Descriptor: Glutamate receptor ionotropic, kainate 3 Authors: Kumari, J, Kumar, J. Deposit date: 2019-02-13 Release date: 2019-07-24 Last modified: 2019-11-06 Method: ELECTRON MICROSCOPY (7.4 Å) Cite: Structural and Functional Insights into GluK3-kainate Receptor Desensitization and Recovery. Sci Rep, 9, 2019
6JFZ	GluK3 receptor complex with UBP310 Descriptor: Glutamate receptor ionotropic, kainate 3 Authors: Kumari, J, Kumar, J. Deposit date: 2019-02-13 Release date: 2019-07-24 Last modified: 2019-11-06 Method: ELECTRON MICROSCOPY (7.6 Å) Cite: Structural and Functional Insights into GluK3-kainate Receptor Desensitization and Recovery. Sci Rep, 9, 2019
6JMV	Crystal structure of the GluK3 ligand binding domain complex with SYM and zinc Descriptor: 2S,4R-4-METHYLGLUTAMATE, ACETATE ION, CHLORIDE ION, ... Authors: Kumari, J, Kumar, J. Deposit date: 2019-03-13 Release date: 2019-07-24 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.832 Å) Cite: Structural and Functional Insights into GluK3-kainate Receptor Desensitization and Recovery. Sci Rep, 9, 2019
6KSP	Rat GluD1 receptor(splayed conformation) in complex with 7-CKA and Calcium ions Descriptor: Glutamate receptor ionotropic, delta-1 Authors: Burada, A.P, Kumar, J. Deposit date: 2019-08-24 Release date: 2020-01-15 Last modified: 2020-01-29 Method: ELECTRON MICROSCOPY (8.1 Å) Cite: Cryo-EM structures of the ionotropic glutamate receptor GluD1 reveal a non-swapped architecture. Nat.Struct.Mol.Biol., 27, 2020
6KZM	GluK3 receptor complex with kainate Descriptor: Glutamate receptor ionotropic, kainate 3 Authors: Kumar, J, Kumari, J, Burada, A.P. Deposit date: 2019-09-24 Release date: 2020-03-04 Method: ELECTRON MICROSCOPY (9.6 Å) Cite: Structural dynamics of the GluK3-kainate receptor neurotransmitter binding domains revealed by cryo-EM. Int.J.Biol.Macromol., 149, 2020
6L6F	GluK3 receptor complex with UBP301 Descriptor: Glutamate receptor ionotropic, kainate 3 Authors: Kumar, J, Kumari, J, Burada, A.P. Deposit date: 2019-10-28 Release date: 2020-03-04 Method: ELECTRON MICROSCOPY (10.6 Å) Cite: Structural dynamics of the GluK3-kainate receptor neurotransmitter binding domains revealed by cryo-EM. Int.J.Biol.Macromol., 149, 2020
6KSS	Rat GluD1 receptor(compact conformation) in complex with 7-CKA and Calcium ions Descriptor: Glutamate receptor ionotropic, delta-1 Authors: Burada, A.P, Kumar, J. Deposit date: 2019-08-26 Release date: 2020-01-15 Last modified: 2020-01-29 Method: ELECTRON MICROSCOPY (8.1 Å) Cite: Cryo-EM structures of the ionotropic glutamate receptor GluD1 reveal a non-swapped architecture. Nat.Struct.Mol.Biol., 27, 2020

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