3O29

Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator

Summary for 3O29

Entry DOI	10.2210/pdb3o29/pdb
Related	3O28 3O2A 3O6G 3O6H 3O6I 3PMV 3PMW 3PMX
Descriptor	Glutamate receptor 2, GLUTAMIC ACID, SULFATE ION, ... (6 entities in total)
Functional Keywords	transport protein, membrane protein, fusion protein, chimera protein
Biological source	Rattus norvegicus (rat) More
Cellular location	Cell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains	1
Total formula weight	30382.88
Authors	Maclean, J.K.F.,Basten, S.,Campbell, R.A.,Cumming, I.A.,Gillen, K.J.,Gillespie, J.,Jamieson, C.,Kazemier, B.,Kiczun, M.,Lamont, Y.,Lyons, A.J.,Moir, E.M.,Morrow, J.A.,Papakosta, M.,Rankovic, Z.,Smith, L. (deposition date: 2010-07-22, release date: 2010-09-15, Last modification date: 2017-08-09)
Primary citation	Jamieson, C.,Basten, S.,Campbell, R.A.,Cumming, I.A.,Gillen, K.J.,Gillespie, J.,Kazemier, B.,Kiczun, M.,Lamont, Y.,Lyons, A.J.,Maclean, J.K.,Moir, E.M.,Morrow, J.A.,Papakosta, M.,Rankovic, Z.,Smith, L. A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies. Bioorg.Med.Chem.Lett., 20:5753-5756, 2010 Cited by PubMed: 20805031 DOI: 10.1016/j.bmcl.2010.07.138 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.02 Å)

Structure validation