2I03
 
 | | Crystal structure of human dipeptidyl peptidase 4 (DPP IV) with potent alkynyl cyanopyrrolidine (ABT-279) | | Descriptor: | 2-[4-({2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-2-OXOETHYL}AMINO)-4-METHYLPIPERIDIN-1-YL]ISONICOTINIC ACID, Dipeptidyl peptidase 4 | | Authors: | Longenecker, K.L, Madar, D.J. | | Deposit date: | 2006-08-09 | | Release date: | 2006-12-12 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.
J.Med.Chem., 49, 2006
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8ZWO
 | | Structure of CTF18-PCNA with ATP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, ... | | Authors: | Briola, G.R, Tehseen, M, Al-Amodi, A, Nguyen, P.Q, Savva, C.G, Hamdan, S.M, De Biasio, A. | | Deposit date: | 2024-06-13 | | Release date: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Structure of the human CTF18 clamp loader bound to PCNA
To Be Published
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8ZSE
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2VGD
 | | Crystal structure of environmental isolated GH11 in complex with xylobiose and feruloyl-arabino-xylotriose | | Descriptor: | 5-O-[(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]-alpha-L-ribofuranose, ENXYN11A, GLYCEROL, ... | | Authors: | Vardakou, M, Dumon, C, Flint, J.E, Murray, J.W, Christakopoulos, P, Weiner, D.P, Juge, N, Lewis, R.J, Gilbert, H.J. | | Deposit date: | 2007-11-12 | | Release date: | 2007-12-25 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Understanding the Structural Basis for Substrate and Inhibitor Recognition in Eukaryotic Gh11 Xylanases.
J.Mol.Biol., 375, 2008
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8ZVL
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5JQY
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5JRA
 | | Nitric oxide complex of the L16V mutant of cytochrome c prime from Alcaligenes xylosoxidans | | Descriptor: | ASCORBIC ACID, Cytochrome c', HEME C, ... | | Authors: | Kekilli, D, Strange, R.W, Hough, M.A. | | Deposit date: | 2016-05-06 | | Release date: | 2017-03-08 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | Engineering proximal vs. distal heme-NO coordination via dinitrosyl dynamics: implications for NO sensor design.
Chem Sci, 8, 2017
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8ZXV
 | | sweet protein MNEI-Mut 6-4 | | Descriptor: | Monellin chain B,Monellin chain A | | Authors: | You, T.J, Liu, S. | | Deposit date: | 2024-06-15 | | Release date: | 2025-06-18 | | Last modified: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.43 Å) | | Cite: | Structural Basis for the Exceptional Thermal Stability of the Boiling-Resistant Sweet Protein MNEI.
J.Agric.Food Chem., 73, 2025
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8ZXT
 | | sweet protein MNEI-Mut 6-3 | | Descriptor: | Monellin chain B,Monellin chain A | | Authors: | You, T.J, Liu, S. | | Deposit date: | 2024-06-15 | | Release date: | 2025-06-18 | | Last modified: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Basis for the Exceptional Thermal Stability of the Boiling-Resistant Sweet Protein MNEI.
J.Agric.Food Chem., 73, 2025
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5JSG
 | | Crystal structure of Spindlin1 bound to compound EML405 | | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Spindlin-1, ... | | Authors: | Su, X, Li, H. | | Deposit date: | 2016-05-08 | | Release date: | 2017-05-10 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Developing Spindlin1 small-molecule inhibitors by using protein microarrays
Nat. Chem. Biol., 13, 2017
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8ZXS
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1KW9
 | | Crystal structure of 2,3-dihydroxybiphenyl dioxygenase (BphC) in complex with 2,3-dihydroxybiphenyl at 2.0A resolution | | Descriptor: | 2,3-Dihydroxybiphenyl dioxygenase, BIPHENYL-2,3-DIOL, FE (II) ION | | Authors: | Sato, N, Uragami, Y, Nishizaki, T, Takahashi, Y, Sazaki, G, Sugimoto, K, Nonaka, T, Masai, E, Fukuda, M, Senda, T. | | Deposit date: | 2002-01-29 | | Release date: | 2003-01-29 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal Structures of the Reaction Intermediate and its Homologue of an Extradiol-cleaving Catecholic Dioxygenase
J.Mol.Biol., 321, 2002
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8ZFI
 | | Structure of E.coli ribosome in complex with an engineered arrest peptide and trigger factor | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S13, ... | | Authors: | Sriramoju, M.K, Ko, T.P, Draczkowski, P, Hsu, S.T.D. | | Deposit date: | 2024-05-07 | | Release date: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure of E.coli ribosome in complex with an engineered arrest peptide and trigger factor
To Be Published
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8ZVE
 | | Solution structure of free TMPRSS2 promoter G-quadruplex | | Descriptor: | DNA (5'-D(*TP*CP*TP*GP*GP*GP*CP*GP*GP*GP*CP*GP*AP*GP*GP*GP*CP*GP*GP*GP*AP*GP*C)-3') | | Authors: | Wang, K.B. | | Deposit date: | 2024-06-11 | | Release date: | 2025-06-18 | | Method: | SOLUTION NMR | | Cite: | NMR Solution Structure of the Major TMPRSS2 Promoter G-Quadruplex and Its Complex with Berberine
To Be Published
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7RNN
 | | Human ASIC1a-Nb.C1 complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, Nanobodies Nb.C1 | | Authors: | Wu, Y, Chen, Z, Sigworth, F.J, Canessa, C.M. | | Deposit date: | 2021-07-29 | | Release date: | 2021-08-11 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Structure and analysis of nanobody binding to the human ASIC1a ion channel.
Elife, 10, 2021
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8ZVP
 | | Human SIRT6 in complex with EGCG | | Descriptor: | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, NAD-dependent protein deacylase sirtuin-6, ZINC ION, ... | | Authors: | Song, B, Wang, Y. | | Deposit date: | 2024-06-11 | | Release date: | 2025-06-18 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | SIRT6 in complex with EGCG
To Be Published
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2HY7
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5JPH
 | | Structure of a GNAT acetyltransferase SACOL1063 from Staphylococcus aureus in complex with CoA | | Descriptor: | Acetyltransferase SACOL1063, CHLORIDE ION, COENZYME A | | Authors: | Majorek, K.A, Osinski, T, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2016-05-03 | | Release date: | 2016-06-29 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | Insight into the 3D structure and substrate specificity of previously uncharacterized GNAT superfamily acetyltransferases from pathogenic bacteria.
Biochim.Biophys.Acta, 1865, 2016
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8ZR7
 | | Crystal structure of Skd3 | | Descriptor: | Caseinolytic peptidase B protein homolog, PHOSPHATE ION | | Authors: | Lee, S, Lee, C. | | Deposit date: | 2024-06-04 | | Release date: | 2025-06-11 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of Skd3
To Be Published
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8ZTB
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5JPZ
 | | Crystal structure of HAT domain of human Squamous Cell Carcinoma Antigen Recognized By T Cells 3, SART3 (TIP110) | | Descriptor: | Squamous cell carcinoma antigen recognized by T-cells 3 | | Authors: | Grazette, A, Harper, S, Emsley, J, Layfield, R, Dreveny, I. | | Deposit date: | 2016-05-04 | | Release date: | 2016-05-11 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.045 Å) | | Cite: | unpublished
To Be Published
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8ZW3
 | | Solution structure of TMPRSS2 promoter G-quadruplex | | Descriptor: | BERBERINE, DNA (5'-D(*TP*CP*TP*GP*GP*GP*CP*GP*GP*GP*CP*GP*AP*GP*GP*GP*CP*GP*GP*GP*AP*GP*C)-3') | | Authors: | Wang, K.B. | | Deposit date: | 2024-06-12 | | Release date: | 2025-06-18 | | Method: | SOLUTION NMR | | Cite: | NMR Solution Structure of the Major TMPRSS2 Promoter G-Quadruplex and Its Complex with Berberine
To Be Published
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5JQE
 | | Crystal structure of caspase8 tDED | | Descriptor: | Sugar ABC transporter substrate-binding protein,Caspase-8 chimera | | Authors: | Fu, T, Li, Y, Lu, A, Wu, H. | | Deposit date: | 2016-05-04 | | Release date: | 2016-10-26 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3.157 Å) | | Cite: | Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.
Mol. Cell, 64, 2016
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2HYQ
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8ZVV
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