7A3N

Crystal structure of Zika virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE1 C10

Summary for 7A3N

• Entry DOI: 10.2210/pdb7a3n/pdb
• Related: 7A3O 7A3P 7A3Q 7A3R 7A3S 7A3T 7A3U 7CTH
• Descriptor: Core protein, EDE1 C10 Fab, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: viral protein, flavivirus, class 2 fusion protein, antibody, fab, immunocomplex, zika, broadly neutralising antibody
• Biological source: Zika virus (ZIKV); More
• Total number of polymer chains: 3
• Total formula weight: 96967.40

Authors

Sharma, A.,Vaney, M.C.,Guardado-Calvo, P.,Duquerroy, S.,Rouvinski, A.,Rey, F.A. (deposition date: 2020-08-18, release date: 2021-12-08, Last modification date: 2024-01-31)

• Primary citation: Sharma, A.,Zhang, X.,Dejnirattisai, W.,Dai, X.,Gong, D.,Wongwiwat, W.,Duquerroy, S.,Rouvinski, A.,Vaney, M.C.,Guardado-Calvo, P.,Haouz, A.,England, P.,Sun, R.,Zhou, Z.H.,Mongkolsapaya, J.,Screaton, G.R.,Rey, F.A.; The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses.; Cell, 184:6052-6066.e18, 2021; PubMed: 34852239; DOI: 10.1016/j.cell.2021.11.010

Experimental method

X-RAY DIFFRACTION (2.1 Å)