7A3U

Crystal structure of Zika virus envelope glycoprotein in complex with the divalent F(ab')2 fragment of the broadly neutralizing human antibody EDE1 C10

Summary for 7A3U

Entry DOI	10.2210/pdb7a3u/pdb
Related	7A3N 7A3O 7A3P 7A3Q 7A3R 7A3S 7A3T 7CTH
Descriptor	Envelope protein, EDE1 C10 antibody divalent F(ab')2 fragment, EDE1 C10 divalent F(ab')2 fragment, ... (4 entities in total)
Functional Keywords	viral protein, flavivirus, class 2 fusion protein, immunocomplex, zika, antibody, f(ab')2
Biological source	Zika virus (ZIKV) More
Total number of polymer chains	3
Total formula weight	96845.46
Authors	Sharma, A.,Vaney, M.C.,Guardado-Calvo, P.,Duquerroy, S.,Rouvinski, A.,Rey, F.A. (deposition date: 2020-08-18, release date: 2021-12-08, Last modification date: 2021-12-22)
Primary citation	Sharma, A.,Zhang, X.,Dejnirattisai, W.,Dai, X.,Gong, D.,Wongwiwat, W.,Duquerroy, S.,Rouvinski, A.,Vaney, M.C.,Guardado-Calvo, P.,Haouz, A.,England, P.,Sun, R.,Zhou, Z.H.,Mongkolsapaya, J.,Screaton, G.R.,Rey, F.A. The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses. Cell, 184:6052-6066.e18, 2021 Cited by PubMed: 34852239 DOI: 10.1016/j.cell.2021.11.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation