PDB: 325 resultsInfo pagesStatus searchChemie searchBIRD

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3DXJ	Crystal structure of thermus thermophilus rna polymerase holoenzyme in complex with the antibiotic myxopyronin Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, BACTERIAL RNA POLYMERASE BETA SUBUNIT; CHAIN C, M, ... Authors: Das, K, Arnold, E. Deposit date: 2008-07-24 Release date: 2008-10-14 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3 Å) Cite: The RNA polymerase "switch region" is a target for inhibitors. Cell(Cambridge,Mass.), 135, 2008
3EQL	Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic myxopyronin Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Vassylyev, D.G, Vassylyeva, M.N, Artsimovitch, I. Deposit date: 2008-09-30 Release date: 2008-10-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Transcription inactivation through local refolding of the RNA polymerase structure. Nature, 457, 2009
2Q1Z	Crystal Structure of Rhodobacter sphaeroides SigE in complex with the anti-sigma ChrR Descriptor: Anti-Sigma factor ChrR, transcriptional activator ChrR, RpoE, ... Authors: Campbell, E.A, Darst, S.A. Deposit date: 2007-05-25 Release date: 2007-09-18 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.4 Å) Cite: A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria. Mol.Cell, 27, 2007
3IYD	Three-dimensional EM structure of an intact activator-dependent transcription initiation complex Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator, DNA (98-MER), ... Authors: Hudson, B.P, Quispe, J, Lara, S, Kim, Y, Berman, H, Arnold, E, Ebright, R.H, Lawson, C.L. Deposit date: 2009-08-01 Release date: 2009-11-10 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (19.799999 Å) Cite: Three-dimensional EM structure of an intact activator-dependent transcription initiation complex Proc.Natl.Acad.Sci.USA, 106, 2009
3WOD	RNA polymerase-gp39 complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Tagami, S, Sekine, S, Minakhin, L, Esyunina, D, Akasaka, R, Shirouzu, M, Kulbachinskiy, A, Severinov, K, Yokoyama, S. Deposit date: 2013-12-26 Release date: 2014-03-12 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural basis for promoter specificity switching of RNA polymerase by a phage factor. Genes Dev., 28, 2014
6BZO	Mtb RNAP Holo/RbpA/Fidaxomicin/upstream fork DNA Descriptor: DNA (26-MER), DNA (32-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. Deposit date: 2017-12-25 Release date: 2018-03-28 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts. Elife, 7, 2018
6C06	Mycobacterium tuberculosis RNAP Holo/RbpA/Fidaxomicin Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J, Lilic, M. Deposit date: 2017-12-27 Release date: 2018-03-28 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (5.15 Å) Cite: Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts. Elife, 7, 2018
6B6H	The cryo-EM structure of a bacterial class I transcription activation complex Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Liu, B, Hong, C, Huang, R, Yu, Z, Steitz, T.A. Deposit date: 2017-10-02 Release date: 2017-11-15 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural basis of bacterial transcription activation. Science, 358, 2017
5IPN	SigmaS-transcription initiation complex with 4-nt nascent RNA Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Liu, B, Zuo, Y, Steitz, T.A. Deposit date: 2016-03-09 Release date: 2016-03-30 Last modified: 2016-06-22 Method: X-RAY DIFFRACTION (4.61 Å) Cite: Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
5IPL	SigmaS-transcription initiation complex with 4-nt nascent RNA Descriptor: DIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Liu, B, Zuo, Y, Steitz, T.A. Deposit date: 2016-03-09 Release date: 2016-03-30 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
5I2D	Crystal structure of T. thermophilus TTHB099 class II transcription activation complex: TAP-RPo Descriptor: DNA (72-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Feng, Y, Zhang, Y, Ebright, R.H. Deposit date: 2016-02-08 Release date: 2016-06-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (4.405 Å) Cite: Structural basis of transcription activation. Science, 352, 2016
5IPM	SigmaS-transcription initiation complex with 4-nt nascent RNA Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Liu, B, Zuo, Y, Steitz, T.A. Deposit date: 2016-03-09 Release date: 2016-03-30 Last modified: 2016-06-22 Method: X-RAY DIFFRACTION (4.2 Å) Cite: Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
5TMF	Re-refinement of thermus thermophilus RNA polymerase Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Wang, J. Deposit date: 2016-10-12 Release date: 2016-11-23 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (3 Å) Cite: On the validation of crystallographic symmetry and the quality of structures. Protein Sci., 24, 2015
5TMC	Re-refinement of Thermus thermopiles DNA-directed RNA polymerase structure Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Wang, J. Deposit date: 2016-10-12 Release date: 2016-11-23 Last modified: 2019-02-20 Method: X-RAY DIFFRACTION (2.71 Å) Cite: On the validation of crystallographic symmetry and the quality of structures. Protein Sci., 24, 2015
5TJG	Thermus aquaticus delta1.1-sigmaA holoenzyme/downstream-fork promoter complex with an open clamp Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*A)-3'), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Darst, S.A, Bae, B. Deposit date: 2016-10-04 Release date: 2017-06-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.6 Å) Cite: RNA polymerase motions during promoter melting. Science, 356, 2017
5UHB	Crystal structure of Mycobacterium tuberculosis transcription initiation complex in complex with Rifampin Descriptor: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Lin, W, Das, K, Feng, Y, Ebright, R.H. Deposit date: 2017-01-11 Release date: 2017-04-12 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (4.29 Å) Cite: Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
7F75	Cryo-EM structure of Spx-dependent transcription activation complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Lin, W, Feng, Y, Shi, J. Deposit date: 2021-06-28 Release date: 2021-10-13 Last modified: 2022-02-16 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structural basis of transcription activation by the global regulator Spx. Nucleic Acids Res., 49, 2021
7PP4	Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme comprising sigma factor SigB Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Brodolin, K. Deposit date: 2021-09-13 Release date: 2022-09-21 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization Nat Commun, 14, 2023
7Q4U	Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme octamer comprising sigma factor SigB Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Brodolin, K. Deposit date: 2021-11-02 Release date: 2022-11-16 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (4.39 Å) Cite: Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization Nat Commun, 14, 2023
7Q59	Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme dimer comprising sigma factor SigB Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Brodolin, K. Deposit date: 2021-11-03 Release date: 2022-11-16 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (4.36 Å) Cite: Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization Nat Commun, 14, 2023
1IW7	Crystal structure of the RNA polymerase holoenzyme from Thermus thermophilus at 2.6A resolution Descriptor: LEAD (II) ION, MAGNESIUM ION, RNA polymerase alpha subunit, ... Authors: RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2002-04-22 Release date: 2002-06-26 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution NATURE, 417, 2002
7F0R	Cryo-EM structure of Pseudomonas aeruginosa SutA transcription activation complex Descriptor: DNA (70-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: He, D.W, You, L.L, Zhang, Y. Deposit date: 2021-06-06 Release date: 2022-07-27 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (5.8 Å) Cite: Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding. Nat Commun, 13, 2022
5D4C	Crystal structure of Thermus thermophilus product complex for transcription initiation with ATP and CTP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2015-08-07 Release date: 2016-07-06 Last modified: 2024-07-03 Method: X-RAY DIFFRACTION (3.28 Å) Cite: The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA. Nature, 535, 2016
7UBM	Transcription antitermination complex: "pre-engaged" Qlambda-loading complex Descriptor: Antitermination protein Q, DNA (52-MER), DNA (53-MER), ... Authors: Yin, Z, Ebright, R.H. Deposit date: 2022-03-15 Release date: 2022-09-28 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.13 Å) Cite: In transcription antitermination by Q lambda , NusA induces refolding of Q lambda to form a nozzle that extends the RNA polymerase RNA-exit channel. Proc.Natl.Acad.Sci.USA, 119, 2022
7UBN	Transcription antitermination complex: NusA-containing "engaged" Qlambda-loading complex Descriptor: Antitermination protein, DNA (52-MER), DNA (53-MER), ... Authors: Yin, Z, Ebright, R.H. Deposit date: 2022-03-15 Release date: 2022-09-28 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.36 Å) Cite: In transcription antitermination by Q lambda , NusA induces refolding of Q lambda to form a nozzle that extends the RNA polymerase RNA-exit channel. Proc.Natl.Acad.Sci.USA, 119, 2022

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