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2ZYF
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BU of 2zyf by Molmil
Crystal structure of homocitrate synthase from Thermus thermophilus complexed with magnesuim ion and alpha-ketoglutarate
Descriptor: 2-OXOGLUTARIC ACID, Homocitrate synthase, MAGNESIUM ION
Authors:Okada, T, Tomita, T, Kuzuyama, T, Nishiyama, M.
Deposit date:2009-01-20
Release date:2009-12-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Mechanism of substrate recognition and insight into feedback inhibition of homocitrate synthase from thermus thermophilus
J.Biol.Chem., 2009
3HBL
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BU of 3hbl by Molmil
Crystal Structure of S. aureus Pyruvate Carboxylase T908A Mutant
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Tong, L, Yu, L.P.C.
Deposit date:2009-05-04
Release date:2009-06-30
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A.
Structure, 17, 2009
3HB9
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BU of 3hb9 by Molmil
Crystal Structure of S. aureus Pyruvate Carboxylase A610T Mutant
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Tong, L, Yu, L.P.C.
Deposit date:2009-05-04
Release date:2009-06-30
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A.
Structure, 17, 2009
3HO8
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BU of 3ho8 by Molmil
Crystal Structure of S. aureus Pyruvate Carboxylase in complex with Coenzyme A
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, MANGANESE (II) ION, ...
Authors:Tong, L, Yu, L.P.C.
Deposit date:2009-06-01
Release date:2009-06-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A.
Structure, 17, 2009
3HPS
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BU of 3hps by Molmil
Crystal structure of Mycobacterium tuberculosis LeuA complexed with ketoisocaproate (KIC)
Descriptor: 2-OXO-4-METHYLPENTANOIC ACID, 2-isopropylmalate synthase, GLYCEROL, ...
Authors:Koon, N, Squire, C.J, Baker, E.N.
Deposit date:2009-06-04
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Probing the active site of M. tuberculosis LeuA
To be Published
3HPX
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BU of 3hpx by Molmil
Crystal structure of Mycobacterium tuberculosis LeuA active site domain 1-425 (truncation mutant delta:426-644)
Descriptor: 2-isopropylmalate synthase, GLYCEROL, NICKEL (II) ION
Authors:Koon, N, Squire, C.J, Baker, E.N.
Deposit date:2009-06-05
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding
Biochemistry, 51, 2012
3HQ1
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BU of 3hq1 by Molmil
Crystal structure of Mycobacterium tuberculosis LeuA complexed with citrate and Mn2+
Descriptor: 2-isopropylmalate synthase, CHLORIDE ION, CITRATE ANION, ...
Authors:Koon, N, Squire, C.J, Baker, E.N.
Deposit date:2009-06-05
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Probing the active site of M. tuberculosis LeuA
To be Published
3HPZ
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BU of 3hpz by Molmil
Crystal structure of Mycobacterium tuberculosis LeuA complexed with bromopyruvate
Descriptor: 2-isopropylmalate synthase, Bromopyruvate, CHLORIDE ION, ...
Authors:Koon, N, Squire, C.J, Baker, E.N.
Deposit date:2009-06-05
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Probing the active site of M. tuberculosis LeuA
To be Published
3IVS
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BU of 3ivs by Molmil
Homocitrate Synthase Lys4
Descriptor: COBALT (II) ION, Homocitrate synthase, mitochondrial, ...
Authors:Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C.
Deposit date:2009-09-01
Release date:2009-09-22
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
3IVU
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BU of 3ivu by Molmil
Homocitrate Synthase Lys4 bound to 2-OG
Descriptor: 2-OXOGLUTARIC ACID, COBALT (II) ION, Homocitrate synthase, ...
Authors:Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C.
Deposit date:2009-09-01
Release date:2009-09-22
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
3IVT
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BU of 3ivt by Molmil
Homocitrate Synthase Lys4 bound to 2-OG
Descriptor: 2-OXOGLUTARIC ACID, Homocitrate synthase, mitochondrial, ...
Authors:Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C.
Deposit date:2009-09-01
Release date:2009-09-22
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
3A9I
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BU of 3a9i by Molmil
Crystal structure of homocitrate synthase from Thermus thermophilus complexed with Lys
Descriptor: COBALT (II) ION, Homocitrate synthase, LYSINE
Authors:Okada, T, Tomita, T, Kuzuyama, T, Nishiyama, M.
Deposit date:2009-10-28
Release date:2009-12-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of substrate recognition and insight into feedback inhibition of homocitrate synthase from Thermus thermophilus
J.Biol.Chem., 285, 2010
3MI3
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BU of 3mi3 by Molmil
Homocitrate Synthase Lys4 bound to Lysine
Descriptor: Homocitrate synthase, mitochondrial, LYSINE, ...
Authors:Bulfer, S.L, Scott, E.M, Pillus, L, Trievel, R.C.
Deposit date:2010-04-09
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural Basis for L-lysine Feedback Inhibition of Homocitrate Synthase
J.Biol.Chem., 285, 2010
3MP5
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BU of 3mp5 by Molmil
Crystal Structure of Human Lyase R41M in complex with HMG-CoA
Descriptor: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, Hydroxymethylglutaryl-CoA lyase, MAGNESIUM ION
Authors:Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P.
Deposit date:2010-04-24
Release date:2010-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
3MP4
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BU of 3mp4 by Molmil
Crystal structure of Human lyase R41M mutant
Descriptor: Hydroxymethylglutaryl-CoA lyase
Authors:Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P.
Deposit date:2010-04-24
Release date:2010-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
3MP3
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BU of 3mp3 by Molmil
Crystal Structure of Human Lyase in complex with inhibitor HG-CoA
Descriptor: (3R,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, 3-HYDROXYPENTANEDIOIC ACID, Hydroxymethylglutaryl-CoA lyase, ...
Authors:Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P.
Deposit date:2010-04-24
Release date:2010-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
3RMJ
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BU of 3rmj by Molmil
Crystal structure of truncated alpha-Isopropylmalate Synthase from Neisseria meningitidis
Descriptor: 2-isopropylmalate synthase, GLYCEROL, MAGNESIUM ION, ...
Authors:Huisman, F.H.A, Baker, H.M, Koon, N, Baker, E.N, Parker, E.J.
Deposit date:2011-04-20
Release date:2012-03-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding
Biochemistry, 51, 2012
3TW7
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BU of 3tw7 by Molmil
Structure of Rhizobium etli pyruvate carboxylase T882A crystallized without acetyl coenzyme-A
Descriptor: CHLORIDE ION, MAGNESIUM ION, Pyruvate carboxylase protein, ...
Authors:St Maurice, M, Kumar, S, Lietzan, A.D.
Deposit date:2011-09-21
Release date:2011-10-12
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Interaction between the biotin carboxyl carrier domain and the biotin carboxylase domain in pyruvate carboxylase from Rhizobium etli.
Biochemistry, 50, 2011
3TW6
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BU of 3tw6 by Molmil
Structure of Rhizobium etli pyruvate carboxylase T882A with the allosteric activator, acetyl coenzyme-A
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
Authors:St Maurice, M, Kumar, S, Lietzan, A.D.
Deposit date:2011-09-21
Release date:2011-10-19
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Interaction between the biotin carboxyl carrier domain and the biotin carboxylase domain in pyruvate carboxylase from Rhizobium etli.
Biochemistry, 50, 2011
3U6W
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BU of 3u6w by Molmil
Truncated M. tuberculosis LeuA (1-425) complexed with KIV
Descriptor: 2-isopropylmalate synthase, 3-METHYL-2-OXOBUTANOIC ACID, GLYCEROL, ...
Authors:Koon, N, Baker, E.N, Squire, C.J.
Deposit date:2011-10-13
Release date:2012-03-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding.
Biochemistry, 51, 2012
4HNU
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BU of 4hnu by Molmil
crystal structure of K442E mutant of S. aureus Pyruvate carboxylase
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Yu, L.P.C, Tong, L.
Deposit date:2012-10-21
Release date:2013-01-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis.
Biochemistry, 52, 2013
4HNV
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BU of 4hnv by Molmil
Crystal structure of R54E mutant of S. aureus Pyruvate carboxylase
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Yu, L.P.C, Tong, L.
Deposit date:2012-10-21
Release date:2013-01-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis.
Biochemistry, 52, 2013
4HNT
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BU of 4hnt by Molmil
crystal structure of F403A mutant of S. aureus Pyruvate carboxylase
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Yu, L.P.C, Tong, L.
Deposit date:2012-10-21
Release date:2013-01-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis.
Biochemistry, 52, 2013
4JN6
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BU of 4jn6 by Molmil
Crystal Structure of the Aldolase-Dehydrogenase Complex from Mycobacterium tuberculosis HRv37
Descriptor: 4-hydroxy-2-oxovalerate aldolase, Acetaldehyde dehydrogenase, MANGANESE (II) ION, ...
Authors:Carere, J, McKenna, S.E, Kimber, M.S, Seah, S.Y.K.
Deposit date:2013-03-14
Release date:2013-05-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Characterization of an Aldolase-Dehydrogenase Complex from the Cholesterol Degradation Pathway of Mycobacterium tuberculosis.
Biochemistry, 52, 2013
4JX6
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BU of 4jx6 by Molmil
Structure of the carboxyl transferase domain Y628A from Rhizobium etli pyruvate carboxylase with pyruvate
Descriptor: GLYCEROL, MAGNESIUM ION, PYRUVIC ACID, ...
Authors:Lietzan, A.D, St Maurice, M.
Deposit date:2013-03-27
Release date:2013-05-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:A Substrate-induced Biotin Binding Pocket in the Carboxyltransferase Domain of Pyruvate Carboxylase.
J.Biol.Chem., 288, 2013

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