PDB: 167 resultsInfo pagesStatus searchChemie searchBIRD

---

7JP2	Crystal structure of TP0037 from Treponema pallidum, a D-lactate dehydrogenase Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, D-lactate dehydrogenase Authors: Brautigam, C.A, Deka, R.K, Norgard, M.V. Deposit date: 2020-08-07 Release date: 2020-09-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.38 Å) Cite: Biophysical and Biochemical Characterization of TP0037, a d-Lactate Dehydrogenase, Supports an Acetogenic Energy Conservation Pathway in Treponema pallidum. Mbio, 11, 2020
5Z20	The ternary structure of D-lactate dehydrogenase from Pseudomonas aeruginosa with NADH and oxamate Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, D-lactate dehydrogenase (Fermentative), DI(HYDROXYETHYL)ETHER, ... Authors: Furukawa, N, Miyanaga, A, Nakajima, M, Taguchi, H. Deposit date: 2017-12-28 Release date: 2018-09-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Basis of Sequential Allosteric Transitions in Tetrameric d-Lactate Dehydrogenases from Three Gram-Negative Bacteria. Biochemistry, 57, 2018
8HPG	Crystal structure of phenylpyruvate reductase from Lactobacillus sp. CGMCC 9967 Descriptor: Phenylpyruvate reductase Authors: Yang, J.H, Song, W. Deposit date: 2022-12-12 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (3.895 Å) Cite: One-Pot Biocatalytic Transformation of L-DOPA to D-Danshensu To Be Published
5Z21	The ternary structure of D-lactate dehydrogenase from Fusobacterium nucleatum with NADH and oxamate Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, D-lactate dehydrogenase, OXAMIC ACID Authors: Furukawa, N, Miyanaga, A, Nakajima, M, Taguchi, H. Deposit date: 2017-12-28 Release date: 2018-09-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Basis of Sequential Allosteric Transitions in Tetrameric d-Lactate Dehydrogenases from Three Gram-Negative Bacteria. Biochemistry, 57, 2018
4LCE	CtBP1 in complex with substrate MTOB Descriptor: 4-(METHYLSULFANYL)-2-OXOBUTANOIC ACID, C-terminal-binding protein 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Hilbert, B.J, Schiffer, C.A, Royer Jr, W.E. Deposit date: 2013-06-21 Release date: 2014-03-19 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.38 Å) Cite: Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design. Febs Lett., 588, 2014
4LCJ	CtBP2 in complex with substrate MTOB Descriptor: 4-(METHYLSULFANYL)-2-OXOBUTANOIC ACID, C-terminal-binding protein 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Hilbert, B.J, Schiffer, C.A, Royer Jr, W.E. Deposit date: 2013-06-21 Release date: 2014-03-19 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.86 Å) Cite: Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design. Febs Lett., 588, 2014
2CUK	Crystal structure of TT0316 protein from Thermus thermophilus HB8 Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, glycerate dehydrogenase/glyoxylate reductase Authors: Lokanath, N.K, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-05-26 Release date: 2006-08-15 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of TT0316 protein from Thermus thermophilus HB8 To be Published
2D0I	Crystal Structure PH0520 protein from Pyrococcus horikoshii OT3 Descriptor: dehydrogenase Authors: Lokanath, N.K, Terao, Y, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-08-02 Release date: 2006-02-02 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structure PH0520 protein from Pyrococcus horikoshii OT3 To be Published
2YQ4	Crystal Structure of D-isomer specific 2-hydroxyacid dehydrogenase from Lactobacillus delbrueckii ssp. bulgaricus Descriptor: D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE Authors: Holton, S.J, Anandhakrishnan, M, Geerlof, A, Wilmanns, M. Deposit date: 2012-11-05 Release date: 2012-11-21 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3.45 Å) Cite: Structural Characterization of D-Isomer Specific 2-Hydroxyacid Dehydrogenase from Lactobacillus Delbrueckii Ssp. Bulgaricus J.Struct.Biol., 181, 2013
7CVP	The Crystal Structure of human PHGDH from Biortus. Descriptor: D-3-phosphoglycerate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Wang, F, Lv, Z, Cheng, W, Lin, D, Miao, Q, Huang, Y. Deposit date: 2020-08-26 Release date: 2020-09-09 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The Crystal Structure of human PHGDH from Biortus. To Be Published
6PLG	Crystal structure of human PHGDH complexed with Compound 15 Descriptor: (2S)-(4-{3-[(4,5-dichloro-1-methyl-1H-indole-2-carbonyl)amino]oxetan-3-yl}phenyl)(pyridin-3-yl)acetic acid, D-3-phosphoglycerate dehydrogenase, D-MALATE Authors: Olland, A, Lakshminarasimhan, D, White, A, Suto, R.K. Deposit date: 2019-06-30 Release date: 2019-07-24 Last modified: 2019-09-04 Method: X-RAY DIFFRACTION (2.93 Å) Cite: Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. Bioorg.Med.Chem.Lett., 29, 2019
2WWR	Crystal Structure of Human Glyoxylate Reductase Hydroxypyruvate Reductase Descriptor: GLYOXYLATE REDUCTASE/HYDROXYPYRUVATE REDUCTASE, MAGNESIUM ION Authors: Booth, M.P.S, Conners, R, Rumsby, G, Brady, R.L. Deposit date: 2009-10-26 Release date: 2010-10-13 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.82 Å) Cite: Structural Basis of Substrate Specificity in Human Glyoxylate Reductase/Hydroxypyruvate Reductase. J.Mol.Biol., 360, 2006
5N53	Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with N-(3-chloro-4-methoxyphenyl) acetamide Descriptor: D-3-phosphoglycerate dehydrogenase, ~{N}-(3-chloranyl-4-methoxy-phenyl)ethanamide Authors: Unterlass, J.E, Basle, A, Blackburn, T.J, Tucker, J, Cano, C, Noble, M.E.M, Curtin, N.J. Deposit date: 2017-02-12 Release date: 2017-04-05 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. Oncotarget, 9, 2018
8ATI	Human CtBP2(31-364) in complex with RAI2 peptide(315-322) Descriptor: DI(HYDROXYETHYL)ETHER, Isoform 2 of C-terminal-binding protein 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Mullapudi, E, Goradia, N, Wilmanns, M. Deposit date: 2022-08-23 Release date: 2023-08-23 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Human CtBP2(31-364) in complex with RAI2 peptide(315-322) To Be Published
8ARI	Cryo-EM structure of human CtBP1/RAI2(303-362) delta(331-341) filament Descriptor: C-terminal-binding protein 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Retinoic acid-induced protein 2 Authors: Mullapudi, E, Goradia, N, Wilmanns, M. Deposit date: 2022-08-16 Release date: 2023-08-23 Method: ELECTRON MICROSCOPY (3 Å) Cite: Cryo-EM structure of human CtBP1/RAI2(303-362) delta(331-341) filament To Be Published
5N6C	Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with NAD and L-Tartrate Descriptor: D-3-phosphoglycerate dehydrogenase, L(+)-TARTARIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Unterlass, J.E, Basle, A, Tucker, J, Cano, C, Noble, M.E.M, Curtin, N.J. Deposit date: 2017-02-14 Release date: 2017-11-22 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH). Oncotarget, 8, 2017
1PSD	THE ALLOSTERIC LIGAND SITE IN THE VMAX-TYPE COOPERATIVE ENZYME PHOSPHOGLYCERATE DEHYDROGENASE Descriptor: D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PHOSPHOGLYCERATE DEHYDROGENASE), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SERINE Authors: Schuller, D.J, Grant, G.A, Banaszak, L.J. Deposit date: 1995-05-02 Release date: 1995-07-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.75 Å) Cite: The allosteric ligand site in the Vmax-type cooperative enzyme phosphoglycerate dehydrogenase. Nat.Struct.Biol., 2, 1995
6PEX	An aldo keto reductase with 2-keto- L-gulonate reductase activity Descriptor: aldo keto reductase Authors: Yong, J, Crystal, S, Robert, D.H, John, B.B. Deposit date: 2019-06-21 Release date: 2019-09-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.581 Å) Cite: An aldo-keto reductase with 2-keto-l-gulonate reductase activity functions in l-tartaric acid biosynthesis from vitamin C inVitis vinifera. J.Biol.Chem., 294, 2019
6PLF	Crystal structure of human PHGDH complexed with Compound 1 Descriptor: 1,2-ETHANEDIOL, 4-{(1S)-1-[(5-chloro-6-{[(5S)-2-oxo-1,3-oxazolidin-5-yl]methoxy}-1H-indole-2-carbonyl)amino]-2-hydroxyethyl}benzoic acid, D-3-phosphoglycerate dehydrogenase Authors: Olland, A, Lakshminarasimhan, D, White, A, Suto, R.K. Deposit date: 2019-06-30 Release date: 2019-07-24 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. Bioorg.Med.Chem.Lett., 29, 2019
1SC6	Crystal Structure of W139G D-3-Phosphoglycerate dehydrogenase complexed with NAD+ Descriptor: D-3-phosphoglycerate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Bell, J.K, Grant, G.A, Banaszak, L.J. Deposit date: 2004-02-11 Release date: 2005-02-22 Last modified: 2021-10-27 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Multiconformational states in phosphoglycerate dehydrogenase Biochemistry, 43, 2004
4S1V	Crystal structure of phosphoglycerate oxidoreductase from Vibrio Cholerae o395 Descriptor: D-3-phosphoglycerate dehydrogenase-related protein Authors: Tarique, K.F, Rehman, S.A.A, Devi, S, Gourinath, S. Deposit date: 2015-01-15 Release date: 2015-01-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal Structure of Phosphoglycerate Oxidoreductase from Vibrio Cholerae O395 To be Published
5NZQ	Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-(1,3-oxazol-5-yl)aniline. Descriptor: 3-(1,3-oxazol-5-yl)aniline, D-3-phosphoglycerate dehydrogenase Authors: Unterlass, J.E, Basle, A, Blackburn, T.J, Tucker, J, Cano, C, Noble, M.E.M, Curtin, N.J. Deposit date: 2017-05-14 Release date: 2017-06-14 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. Oncotarget, 9, 2018
4U6S	CtBP1 in complex with substrate phenylpyruvate Descriptor: 3-PHENYLPYRUVIC ACID, C-terminal-binding protein 1, CALCIUM ION, ... Authors: Hilbert, B.J, Morris, B.L, Ellis, K.C, Paulsen, J.L, Schiffer, C.A, Grossman, S.R, Royer Jr, W.E. Deposit date: 2014-07-29 Release date: 2015-02-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure-Guided Design of a High Affinity Inhibitor to Human CtBP. Acs Chem.Biol., 10, 2015
4U6Q	CtBP1 bound to inhibitor 2-(hydroxyimino)-3-phenylpropanoic acid Descriptor: (2E)-2-(hydroxyimino)-3-phenylpropanoic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, C-terminal-binding protein 1, ... Authors: Hilbert, B.J, Morris, B.L, Ellis, K.C, Paulsen, J.L, Schiffer, C.A, Grossman, S.R, Royer Jr, W.E. Deposit date: 2014-07-29 Release date: 2015-02-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure-Guided Design of a High Affinity Inhibitor to Human CtBP. Acs Chem.Biol., 10, 2015
8BXX	Crystal structure of formate dehydrogenase FDH2 enzyme from Granulicella mallensis MP5ACTX8 in complex with NAD and azide. Descriptor: 1,2-ETHANEDIOL, AZIDE ION, Formate dehydrogenase, ... Authors: Robescu, M.S, Rubini, R, Filippini, F, Bergantino, B, Cendron, L. Deposit date: 2022-12-10 Release date: 2023-01-18 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (1.97 Å) Cite: From the amelioration of a NADP+-dependent formate dehydrogenase to the discovery of a new enzyme: round trip from theory to practice ChemCatChem, 2020

<1234567>