5N6C
Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with NAD and L-Tartrate
Summary for 5N6C
Entry DOI | 10.2210/pdb5n6c/pdb |
Descriptor | D-3-phosphoglycerate dehydrogenase, L(+)-TARTARIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (4 entities in total) |
Functional Keywords | dehydrogenase, serine metabolism, enzymology, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 65788.90 |
Authors | Unterlass, J.E.,Basle, A.,Tucker, J.,Cano, C.,Noble, M.E.M.,Curtin, N.J. (deposition date: 2017-02-14, release date: 2017-11-22, Last modification date: 2024-01-17) |
Primary citation | Unterlass, J.E.,Wood, R.J.,Basle, A.,Tucker, J.,Cano, C.,Noble, M.M.E.,Curtin, N.J. Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH). Oncotarget, 8:104478-104491, 2017 Cited by PubMed: 29262655DOI: 10.18632/oncotarget.22327 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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