Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0051287 | molecular_function | NAD binding |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue TLA A 401 |
| Chain | Residue |
| A | ARG54 |
| A | HOH514 |
| B | ARG135 |
| A | SER55 |
| A | ARG75 |
| A | THR78 |
| A | ARG236 |
| A | HIS283 |
| A | ALA286 |
| A | GLN292 |
| A | NAD402 |
| site_id | AC2 |
| Number of Residues | 26 |
| Details | binding site for residue NAD A 402 |
| Chain | Residue |
| A | THR78 |
| A | ASN102 |
| A | GLY152 |
| A | GLY154 |
| A | ARG155 |
| A | ILE156 |
| A | TYR174 |
| A | ASP175 |
| A | PRO176 |
| A | ILE177 |
| A | HIS206 |
| A | THR207 |
| A | PRO208 |
| A | THR213 |
| A | CYS234 |
| A | ALA235 |
| A | ARG236 |
| A | ASP260 |
| A | HIS283 |
| A | GLY285 |
| A | ALA286 |
| A | TLA401 |
| A | HOH505 |
| A | HOH509 |
| A | HOH520 |
| A | HOH524 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | binding site for residue NAD B 401 |
| Chain | Residue |
| B | GLY152 |
| B | GLY154 |
| B | ARG155 |
| B | ILE156 |
| B | TYR174 |
| B | ASP175 |
| B | PRO176 |
| B | ILE177 |
| B | HIS206 |
| B | THR207 |
| B | PRO208 |
| B | THR213 |
| B | CYS234 |
| B | ALA235 |
| B | ARG236 |
| B | ASP260 |
| B | HIS283 |
| B | GLY285 |
| B | ALA286 |
| B | HOH503 |
| B | HOH514 |
Functional Information from PROSITE/UniProt
| site_id | PS00065 |
| Number of Residues | 28 |
| Details | D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. LGILGlGRIGrevatrmqsfgmk.TIgYD |
| Chain | Residue | Details |
| A | LEU148-ASP175 | |
| site_id | PS00670 |
| Number of Residues | 23 |
| Details | D_2_HYDROXYACID_DH_2 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. IWplCDFItVHtPllpsTtgLlN |
| Chain | Residue | Details |
| A | ILE196-ASN218 | |
| site_id | PS00671 |
| Number of Residues | 17 |
| Details | D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. CKkGvRVVNcARGgIVD |
| Chain | Residue | Details |
| A | CYS225-ASP241 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | ARG236 | |
| B | ARG236 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| B | GLU265 | |
| A | GLU265 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor |
| Chain | Residue | Details |
| A | HIS283 | |
| B | HIS283 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|Ref.21 |
| Chain | Residue | Details |
| A | ASP175 | |
| A | THR207 | |
| A | CYS234 | |
| A | ASP260 | |
| A | HIS283 | |
| B | THR78 | |
| B | ARG155 | |
| B | ASP175 | |
| B | THR207 | |
| B | CYS234 | |
| B | ASP260 | |
| B | HIS283 | |
| A | THR78 | |
| A | ARG155 | |
| Chain | Residue | Details |
| A | SER14 | |
| B | SER14 | |
| Chain | Residue | Details |
| A | LYS21 | |
| B | LYS21 | |
| Chain | Residue | Details |
| A | LYS58 | |
| B | LYS58 | |
| Chain | Residue | Details |
| A | THR78 | |
| B | THR78 | |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211 |
| Chain | Residue | Details |
| B | LYS21 | |
| A | LYS21 | |
