4U6Q

CtBP1 bound to inhibitor 2-(hydroxyimino)-3-phenylpropanoic acid

Summary for 4U6Q

• Entry DOI: 10.2210/pdb4u6q/pdb
• Related: 4LCE 4U6S
• Descriptor: C-terminal-binding protein 1, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, (2E)-2-(hydroxyimino)-3-phenylpropanoic acid, ... (6 entities in total)
• Functional Keywords: rossman fold, transcription regulator, cancer, inhibitor, oxidoreductase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : Q13363
• Total number of polymer chains: 1
• Total formula weight: 39070.19

Authors

Hilbert, B.J.,Morris, B.L.,Ellis, K.C.,Paulsen, J.L.,Schiffer, C.A.,Grossman, S.R.,Royer Jr., W.E. (deposition date: 2014-07-29, release date: 2015-02-11, Last modification date: 2023-09-27)

• Primary citation: Hilbert, B.J.,Morris, B.L.,Ellis, K.C.,Paulsen, J.L.,Schiffer, C.A.,Grossman, S.R.,Royer, W.E.; Structure-Guided Design of a High Affinity Inhibitor to Human CtBP.; Acs Chem.Biol., 10:1118-1127, 2015; PubMed: 25636004; DOI: 10.1021/cb500820b

Experimental method

X-RAY DIFFRACTION (2.3 Å)