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2ZL1
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BU of 2zl1 by Molmil
MP1-p14 Scaffolding complex
Descriptor: Mitogen-activated protein kinase kinase 1-interacting protein 1, Mitogen-activated protein-binding protein-interacting protein
Authors:Schrag, J.D, Cygler, M, Munger, C, Magloire, A.
Deposit date:2008-04-02
Release date:2008-06-24
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular dynamics-solvated interaction energy studies of protein-protein interactions: the MP1-p14 scaffolding complex.
J.Mol.Biol., 379, 2008
4U8G
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BU of 4u8g by Molmil
Crystal structure of 2-keto-3-deoxy-D-gluconate dehydrogenase from Streptococcus agalactiae
Descriptor: Putative uncharacterized protein gbs1891
Authors:Maruyama, Y, Oiki, S, Takase, R, Mikami, B, Murata, K, Hashimoto, W.
Deposit date:2014-08-03
Release date:2014-12-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Metabolic Fate of Unsaturated Glucuronic/Iduronic Acids from Glycosaminoglycans: MOLECULAR IDENTIFICATION AND STRUCTURE DETERMINATION OF STREPTOCOCCAL ISOMERASE AND DEHYDROGENASE.
J.Biol.Chem., 290, 2015
4UEK
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BU of 4uek by Molmil
Galactitol-1-phosphate 5-dehydrogenase from E. coli with Tris within the active site.
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GALACTITOL-1-PHOSPHATE 5-DEHYDROGENASE, ZINC ION
Authors:Benavente, R, Esteban-Torres, M, Kohring, G.W, Cortes-Cabrera, A, Gago, F, Acebron, I, de las Rivas, B, Munoz, R, Mancheno, J.M.
Deposit date:2014-12-18
Release date:2015-07-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Enantioselective Oxidation of Galactitol 1-Phosphate by Galactitol-1-Phosphate 5-Dehydrogenase from Escherichia Coli
Acta Crystallogr.,Sect.D, 71, 2015
1OT7
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BU of 1ot7 by Molmil
Structural Basis for 3-deoxy-CDCA Binding and Activation of FXR
Descriptor: 6-ETHYL-CHENODEOXYCHOLIC ACID, Bile Acid Receptor, ISO-URSODEOXYCHOLIC ACID, ...
Authors:Mi, L.Z, Devarakonda, S, Harp, J.M, Han, Q, Pellicciari, R, Willson, T.M, Khorasanizadeh, S, Rastinejad, F.
Deposit date:2003-03-21
Release date:2004-03-23
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR
Mol.Cell, 11, 2003
4UEJ
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BU of 4uej by Molmil
Closed state of galactitol-1-phosphate 5-dehydrogenase from E. coli in complex with glycerol.
Descriptor: GALACTITOL-1-PHOSPHATE 5-DEHYDROGENASE, GLYCEROL, ZINC ION
Authors:Benavente, R, Esteban-Torres, M, Kohring, G.W, Cortes-Cabrera, A, Gago, F, Acebron, I, de las Rivas, B, Munoz, R, Mancheno, J.M.
Deposit date:2014-12-18
Release date:2015-07-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Enantioselective Oxidation of Galactitol 1-Phosphate by Galactitol-1-Phosphate 5-Dehydrogenase from Escherichia Coli
Acta Crystallogr.,Sect.D, 71, 2015
4UEO
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BU of 4ueo by Molmil
Open state of galactitol-1-phosphate 5-dehydrogenase from E. coli, with zinc in the catalytic site.
Descriptor: GALACTITOL-1-PHOSPHATE 5-DEHYDROGENASE, ZINC ION
Authors:Benavente, R, Esteban-Torres, M, Kohring, G.W, Cortes-Cabrera, A, Gago, F, Acebron, I, de las Rivas, B, Munoz, R, Mancheno, J.M.
Deposit date:2014-12-18
Release date:2015-07-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Enantioselective Oxidation of Galactitol 1-Phosphate by Galactitol-1-Phosphate 5-Dehydrogenase from Escherichia Coli
Acta Crystallogr.,Sect.D, 71, 2015
2FBW
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BU of 2fbw by Molmil
Avian respiratory complex II with carboxin bound
Descriptor: (~{Z})-2-oxidanylbut-2-enedioic acid, 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE, AZIDE ION, ...
Authors:Huang, L.S, Sun, G, Cobessi, D, Wang, A.C, Shen, J.T, Tung, E.Y, Anderson, V.E, Berry, E.A.
Deposit date:2005-12-10
Release date:2005-12-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme.
J.Biol.Chem., 281, 2006
2FIF
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BU of 2fif by Molmil
Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin
Descriptor: Rab5 GDP/GTP exchange factor, SULFATE ION, Ubiquitin, ...
Authors:Lee, S, Hurley, J.H.
Deposit date:2005-12-29
Release date:2006-02-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5
Nat.Struct.Mol.Biol., 13, 2006
6DCX
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BU of 6dcx by Molmil
iASPP-PP-1c structure and targeting of p53
Descriptor: RelA-associated inhibitor, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Authors:Glover, J.N.M, Zhou, Y, Edwards, R.A.
Deposit date:2018-05-08
Release date:2019-05-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.408 Å)
Cite:Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis.
Structure, 27, 2019
5FJJ
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BU of 5fjj by Molmil
Three-dimensional structures of two heavily N-glycosylated Aspergillus sp. Family GH3 beta-D-glucosidases
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BETA-GLUCOSIDASE, ...
Authors:Agirre, J, Ariza, A, Offen, W.A, Turkenburg, J.P, Roberts, S.M, McNicholas, S, Harris, P.V, McBrayer, B, Dohnalek, J, Cowtan, K.D, Davies, G.J, Wilson, K.S.
Deposit date:2015-10-09
Release date:2016-02-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Three-Dimensional Structures of Two Heavily N-Glycosylated Aspergillus Sp. Family Gh3 Beta-D-Glucosidases
Acta Crystallogr.,Sect.D, 72, 2016
2FQ1
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BU of 2fq1 by Molmil
Crystal structure of the two-domain non-ribosomal peptide synthetase EntB containing isochorismate lyase and aryl-carrier protein domains
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Isochorismatase, ...
Authors:Drake, E.J, Nicolai, D.A, Gulick, A.M.
Deposit date:2006-01-17
Release date:2006-05-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the EntB multidomain nonribosomal peptide synthetase and functional analysis of its interaction with the EntE adenylation domain.
Chem.Biol., 13, 2006
8E3H
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BU of 8e3h by Molmil
Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA spacer, Mg-ADP-BeF3, and NusG; Rho hexamer part
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ...
Authors:Molodtsov, V, Wang, C.
Deposit date:2022-08-17
Release date:2022-09-07
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Structural basis of Rho-dependent transcription termination.
Nature, 614, 2023
6UPN
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BU of 6upn by Molmil
Endophilin B1 helical scaffold
Descriptor: Endophilin-B1
Authors:Bhatt, V.S, Sundborger-Lunna, A.C.
Deposit date:2019-10-17
Release date:2020-04-22
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Amphipathic Motifs Regulate N-BAR Protein Endophilin B1 Auto-inhibition and Drive Membrane Remodeling.
Structure, 29, 2021
6F5E
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BU of 6f5e by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DD_D12_10_47 in complex JNK1a1 and JIP1 peptide
Descriptor: C-Jun-amino-terminal kinase-interacting protein 1, DD_D12_10_47, Mitogen-activated protein kinase 8
Authors:Wu, Y, Mittl, P.R, Honegger, A, Batyuk, A, Plueckthun, A.
Deposit date:2017-12-01
Release date:2017-12-13
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of DARPin-DARPin rigid fusion, variant DD_D12_10_47 in complex JNK1a1 and JIP1 peptide
To be published
5G0Q
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BU of 5g0q by Molmil
beta-glucuronidase with an activity-based probe (N-alkyl cyclophellitol aziridine) bound
Descriptor: (1R,2S,3R,4S,5S,6R)-7-(8-AZIDOOCTYL)-3,4,5-TRIHYDROXY-, BETA-GLUCURONIDASE, GLYCEROL
Authors:Jin, Y, Wu, L, Jiang, J.B, Overkleeft, H.S, Davies, G.J.
Deposit date:2016-03-22
Release date:2017-04-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Activity-based probes for functional interrogation of retaining beta-glucuronidases.
Nat. Chem. Biol., 13, 2017
3E1R
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BU of 3e1r by Molmil
Midbody targeting of the ESCRT machinery by a non-canonical coiled-coil in CEP55
Descriptor: Centrosomal protein of 55 kDa, Programmed cell death 6-interacting protein
Authors:Lee, H.H, Elia, N, Ghirlando, R, Lippincott-Schwartz, J, Hurley, J.H.
Deposit date:2008-08-04
Release date:2008-11-04
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55.
Science, 322, 2008
6GFJ
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BU of 6gfj by Molmil
Structure of RIP2 CARD domain fused to crystallisable MBP tag
Descriptor: Sugar ABC transporter substrate-binding protein,Receptor-interacting serine/threonine-protein kinase 2, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Pellegrini, E, Cusack, S.
Deposit date:2018-04-30
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:RIP2 filament formation is required for NOD2 dependent NF-kappa B signalling.
Nat Commun, 9, 2018
5FJI
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BU of 5fji by Molmil
Three-dimensional structures of two heavily N-glycosylated Aspergillus sp. Family GH3 beta-D-glucosidases
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, BETA-GLUCOSIDASE, ...
Authors:Agirre, J, Ariza, A, Offen, W.A, Turkenburg, J.P, Roberts, S.M, McNicholas, S, Harris, P.V, McBrayer, B, Dohnalek, J, Cowtan, K.D, Davies, G.J, Wilson, K.S.
Deposit date:2015-10-09
Release date:2016-02-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Three-Dimensional Structures of Two Heavily N-Glycosylated Aspergillus Sp. Family Gh3 Beta-D-Glucosidases
Acta Crystallogr.,Sect.D, 72, 2016
6FUZ
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BU of 6fuz by Molmil
Crystal structure of the TPR domain of KLC1 in complex with the C-terminal peptide of JIP1
Descriptor: GLYCEROL, Kinesin light chain 1,Kinesin light chain 1,C-Jun-amino-terminal kinase-interacting protein 1, nanobody
Authors:Pernigo, S, Dodding, M.P, Steiner, R.A.
Deposit date:2018-02-28
Release date:2018-05-02
Last modified:2019-09-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors.
Elife, 7, 2018
6EJN
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BU of 6ejn by Molmil
The KLC2 TPR domain bound to the JIP3 leucine zipper domain
Descriptor: C-Jun-amino-terminal kinase-interacting protein 3, Kinesin light chain 2
Authors:Cockburn, J, Hesketh, S.J, Way, M.
Deposit date:2017-09-22
Release date:2018-09-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Insights into Kinesin-1 Activation from the Crystal Structure of KLC2 Bound to JIP3.
Structure, 26, 2018
4HYS
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BU of 4hys by Molmil
Crystal structure of JNK1 in complex with JIP1 peptide and 4-(4-Indazol-1-yl-pyrimidin-2-ylamino)-cyclohexan
Descriptor: C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, trans-4-{[4-(1H-indazol-1-yl)pyrimidin-2-yl]amino}cyclohexanol
Authors:Kuglstatter, A, Janson, C.
Deposit date:2012-11-14
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.415 Å)
Cite:Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead.
Bioorg.Med.Chem.Lett., 23, 2013
4HYU
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BU of 4hyu by Molmil
Crystal structure of JNK1 in complex with JIP1 peptide and 4-{4-[4-(3-Methanesulfonyl-propoxy)-indazol-1-yl]-pyrimidin-2-ylamino}-cyclohexan
Descriptor: C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, trans-4-[(4-{4-[3-(methylsulfonyl)propoxy]-1H-indazol-1-yl}pyrimidin-2-yl)amino]cyclohexanol
Authors:Kuglstatter, A, Ghate, M.
Deposit date:2012-11-14
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.152 Å)
Cite:Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead.
Bioorg.Med.Chem.Lett., 23, 2013
6YLY
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BU of 6yly by Molmil
pre-60S State NE2 (TAP-Flag-Nop53)
Descriptor: 25S rRNA, 5.8S rRNA, 60S ribosomal protein L13-A, ...
Authors:Kater, L, Beckmann, R.
Deposit date:2020-04-07
Release date:2020-07-29
Last modified:2020-09-02
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis.
Mol.Cell, 79, 2020
4IZY
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BU of 4izy by Molmil
Crystal structure of JNK1 in complex with JIP1 peptide and 4-{4-[4-(4-Methanesulfonyl-piperidin-1-yl)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexan
Descriptor: C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, trans-4-[(4-{4-[4-(methylsulfonyl)piperidin-1-yl]-1H-indol-1-yl}pyrimidin-2-yl)amino]cyclohexanol
Authors:Kuglstatter, A, Shao, A.
Deposit date:2013-01-30
Release date:2013-12-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties.
Bioorg.Med.Chem.Lett., 23, 2013
4JJY
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BU of 4jjy by Molmil
Alix V domain
Descriptor: Programmed cell death 6-interacting protein
Authors:Pashkova, N, Gakhar, L, Yu, L, Piper, R.C.
Deposit date:2013-03-08
Release date:2013-06-19
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (6.503 Å)
Cite:The yeast alix homolog bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes.
Dev.Cell, 25, 2013

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