1OT7

Structural Basis for 3-deoxy-CDCA Binding and Activation of FXR

Summary for 1OT7

Related1OSV
DescriptorBile Acid Receptor, dodecamer peptide fragment of RPGR-interacting protein 1, 6-ETHYL-CHENODEOXYCHOLIC ACID, ... (5 entities in total)
Functional Keywordsbile acid, nuclear receptor, coactivator, ligand binding domain, fxr, hormone-growth factor receptor complex, hormone/growth factor receptor
Biological sourceRattus norvegicus (Norway rat)
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Cellular locationNucleus (Probable) Q62735
Total number of polymer chains5
Total molecular weight58712.76
Authors
Mi, L.Z.,Devarakonda, S.,Harp, J.M.,Han, Q.,Pellicciari, R.,Willson, T.M.,Khorasanizadeh, S.,Rastinejad, F. (deposition date: 2003-03-21, release date: 2004-03-23, Last modification date: 2011-07-13)
Primary citation
Mi, L.Z.,Devarakonda, S.,Harp, J.M.,Han, Q.,Pellicciari, R.,Willson, T.M.,Khorasanizadeh, S.,Rastinejad, F.
Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR
Mol.Cell, 11:1093-1100, 2003
PubMed: 12718893 (PDB entries with the same primary citation)
DOI: 10.1016/S1097-2765(03)00112-6
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.283487.9%10.2%7.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 1ot7
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Molmil generated image of 1ot7
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Molmil generated image of 1ot7
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1ot7.pdb1.gz [42.84 KB])
Coordinate files for Biological unit (1ot7.pdb2.gz [45.21 KB])