1OT7
Structural Basis for 3-deoxy-CDCA Binding and Activation of FXR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Bile Acid Receptor | polymer | 229 | 26752.8 | 2 | UniProt (Q62735) Pfam (PF00104) In PDB | Rattus norvegicus (Norway rat) | FXR; Farnesoid X-activated receptor; Farnesol receptor HRR-1; Retinoid X receptor-interacting protein 14; RXR-interacting protein 14 |
| 2 | C, D, E | dodecamer peptide fragment of RPGR-interacting protein 1 | polymer | 12 | 1464.7 | 3 | |||
| 3 | A | 6-ETHYL-CHENODEOXYCHOLIC ACID | non-polymer | 420.6 | 1 | Chemie (CHC) | |||
| 4 | B | ISO-URSODEOXYCHOLIC ACID | non-polymer | 392.6 | 1 | Chemie (IU5) | |||
| 5 | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 57899.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 813.2 | |
| All* | Total formula weight | 58712.8 |
