1OSV

STRUCTURAL BASIS FOR BILE ACID BINDING AND ACTIVATION OF THE NUCLEAR RECEPTOR FXR

Summary for 1OSV

DescriptorBile acid receptor, Nuclear receptor coactivator 2, 6-ETHYL-CHENODEOXYCHOLIC ACID, ... (4 entities in total)
Functional Keywordslbd, bile acid, coactivator, nuclear receptor, dna binding protein
Biological sourceRattus norvegicus (Norway rat)
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Cellular locationNucleus (Probable) Q62735
Nucleus Q61026
Total number of polymer chains5
Total molecular weight58937.02
Authors
Mi, L.Z.,Devarakonda, S.,Harp, J.M.,Han, Q.,Pellicciari, R.,Willson, T.M.,Khorasanizadeh, S.,Rastinejad, F. (deposition date: 2003-03-20, release date: 2004-03-23, Last modification date: 2011-07-13)
Primary citation
Mi, L.Z.,Devarakonda, S.,Harp, J.M.,Han, Q.,Pellicciari, R.,Willson, T.M.,Khorasanizadeh, S.,Rastinejad, F.
Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR
Mol.Cell, 11:1093-1100, 2003
PubMed: 12718893 (PDB entries with the same primary citation)
DOI: 10.1016/S1097-2765(03)00112-6
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.285416.2%10.0%7.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1osv
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Molmil generated image of 1osv
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Molmil generated image of 1osv
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More Biological unit images

Molmil generated image of 1osv
no rotation
Molmil generated image of 1osv
rotated about x axis by 90°
Molmil generated image of 1osv
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1osv.pdb1.gz [43.63 KB])
Coordinate files for Biological unit (1osv.pdb2.gz [46.27 KB])