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1OSV

STRUCTURAL BASIS FOR BILE ACID BINDING AND ACTIVATION OF THE NUCLEAR RECEPTOR FXR

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0006355biological_processregulation of DNA-templated transcription
A0032052molecular_functionbile acid binding
A0038183biological_processbile acid signaling pathway
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0006355biological_processregulation of DNA-templated transcription
B0032052molecular_functionbile acid binding
B0038183biological_processbile acid signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE CHC B 201
ChainResidue
BMET262
BPHE333
BILE349
BTYR358
BPHE363
BTYR366
BHIS444
BLEU284
BMET287
BALA288
BHIS291
BMET325
BPHE326
BARG328
BSER329

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE CHC A 202
ChainResidue
AMET262
AMET325
APHE326
AARG328
ASER329
AILE349
ATYR358
AMET362
ATYR366
AHIS444
ATRP466

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000305|PubMed:12718893, ECO:0007744|PDB:1OSV, ECO:0007744|PDB:1OT7
ChainResidueDetails
AARG328
ATYR358
ATYR366
BARG328
BTYR358
BTYR366

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305|PubMed:12718893, ECO:0007744|PDB:1OSV
ChainResidueDetails
AHIS444
BHIS444

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by PKC/PRKCZ => ECO:0000250|UniProtKB:Q96RI1
ChainResidueDetails
ATHR439
BTHR439

site_idSWS_FT_FI4
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000250|UniProtKB:Q96RI1
ChainResidueDetails
ALYS272
BLYS272

218853

PDB entries from 2024-04-24

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