1OSV
STRUCTURAL BASIS FOR BILE ACID BINDING AND ACTIVATION OF THE NUCLEAR RECEPTOR FXR
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0032052 | molecular_function | bile acid binding |
| A | 0038183 | biological_process | bile acid signaling pathway |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004879 | molecular_function | nuclear receptor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0032052 | molecular_function | bile acid binding |
| B | 0038183 | biological_process | bile acid signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CHC B 201 |
| Chain | Residue |
| B | MET262 |
| B | PHE333 |
| B | ILE349 |
| B | TYR358 |
| B | PHE363 |
| B | TYR366 |
| B | HIS444 |
| B | LEU284 |
| B | MET287 |
| B | ALA288 |
| B | HIS291 |
| B | MET325 |
| B | PHE326 |
| B | ARG328 |
| B | SER329 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE CHC A 202 |
| Chain | Residue |
| A | MET262 |
| A | MET325 |
| A | PHE326 |
| A | ARG328 |
| A | SER329 |
| A | ILE349 |
| A | TYR358 |
| A | MET362 |
| A | TYR366 |
| A | HIS444 |
| A | TRP466 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12718893","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1OSV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OT7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12718893","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1OSV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC/PRKCZ","evidences":[{"source":"UniProtKB","id":"Q96RI1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"UniProtKB","id":"Q96RI1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Motif: {"description":"LXXLL motif 3"} |
| Chain | Residue | Details |
