1OSV
STRUCTURAL BASIS FOR BILE ACID BINDING AND ACTIVATION OF THE NUCLEAR RECEPTOR FXR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bile acid receptor | polymer | 230 | 26850.9 | 2 | UniProt (Q62735) Pfam (PF00104) | Rattus norvegicus (Norway rat) | Farnesoid X-activated receptor, Farnesol receptor HRR-1, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14 |
| 2 | C, D, E (C, D, E) | Nuclear receptor coactivator 2 | polymer | 12 | 1464.7 | 3 | UniProt (Q61026) | NCoA-2, Transcription intermediary factor 2, Glucocorticoid receptor-interacting protein 1, GRIP-1 | |
| 3 | F, G (A, B) | 6-ETHYL-CHENODEOXYCHOLIC ACID | non-polymer | 420.6 | 2 | Chemie (CHC) | |||
| 4 | H, I, J, K, L (A, B, C, D, E) | water | water | 18.0 | 152 | Chemie (HOH) |
Sequence modifications
A, B: 241 - 469 (UniProt: Q62735)
| PDB | External Database | Details |
|---|---|---|
| Ala 240 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 58095.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 841.3 | |
| All* | Total formula weight | 58937.0 |
