5G0Q

beta-glucuronidase with an activity-based probe (N-alkyl cyclophellitol aziridine) bound

Summary for 5G0Q

• Entry DOI: 10.2210/pdb5g0q/pdb
• Related: 5G0M
• Descriptor: BETA-GLUCURONIDASE, (1R,2S,3R,4S,5S,6R)-7-(8-AZIDOOCTYL)-3,4,5-TRIHYDROXY-, GLYCEROL, ... (4 entities in total)
• Functional Keywords: hydrolase, gh79, beta-glucuronidase, activity-based probe, retaining enzyme
• Biological source: ACIDOBACTERIUM CAPSULATUM
• Total number of polymer chains: 1
• Total formula weight: 51360.16

Authors

Jin, Y.,Wu, L.,Jiang, J.B.,Overkleeft, H.S.,Davies, G.J. (deposition date: 2016-03-22, release date: 2017-04-12, Last modification date: 2024-01-10)

• Primary citation: Wu, L.,Jiang, J.,Jin, Y.,Kallemeijn, W.W.,Kuo, C.L.,Artola, M.,Dai, W.,van Elk, C.,van Eijk, M.,van der Marel, G.A.,Codee, J.D.C.,Florea, B.I.,Aerts, J.M.F.G.,Overkleeft, H.S.,Davies, G.J.; Activity-based probes for functional interrogation of retaining beta-glucuronidases.; Nat. Chem. Biol., 13:867-873, 2017; PubMed: 28581485; DOI: 10.1038/nchembio.2395

Experimental method

X-RAY DIFFRACTION (1.65 Å)