7M6L
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![BU of 7m6l by Molmil](/molmil-images/mine/7m6l) | High resolution structure of the membrane embedded skeletal muscle ryanodine receptor | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... | Authors: | Melville, Z, Kim, K, Clarke, O.B, Marks, A.R. | Deposit date: | 2021-03-25 | Release date: | 2021-08-18 | Last modified: | 2022-01-19 | Method: | ELECTRON MICROSCOPY (3.98 Å) | Cite: | High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor. Structure, 30, 2022
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7M6A
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![BU of 7m6a by Molmil](/molmil-images/mine/7m6a) | High resolution structure of the membrane embedded skeletal muscle ryanodine receptor | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... | Authors: | Melville, Z, Kim, K, Clarke, O.B, Marks, A.R. | Deposit date: | 2021-03-25 | Release date: | 2021-09-08 | Last modified: | 2022-01-19 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor. Structure, 30, 2022
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5NJX
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![BU of 5njx by Molmil](/molmil-images/mine/5njx) | Human FKBP51 protein in complex with C-terminal peptide of Human HSP 90-alpha | Descriptor: | HSP90AA1 protein, Peptidyl-prolyl cis-trans isomerase FKBP5, SULFATE ION | Authors: | Kumar, R, Moche, M, Winblad, B, Pavlov, P. | Deposit date: | 2017-03-30 | Release date: | 2017-11-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51. Sci Rep, 7, 2017
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1W26
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![BU of 1w26 by Molmil](/molmil-images/mine/1w26) | Trigger Factor in Complex with the Ribosome forms a Molecular Cradle for Nascent Proteins | Descriptor: | TRIGGER FACTOR | Authors: | Ferbitz, L, Maier, T, Patzelt, H, Bukau, B, Deuerling, E, Ban, N. | Deposit date: | 2004-06-28 | Release date: | 2004-09-02 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Trigger Factor in Complex with the Ribosome Forms a Molecular Cradle for Nascent Proteins Nature, 431, 2004
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5OWJ
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![BU of 5owj by Molmil](/molmil-images/mine/5owj) | The dynamic dimer structure of the chaperone Trigger Factor (conformer 2) | Descriptor: | Trigger factor | Authors: | Morgado, L, Burmann, B.M, Sharpe, T, Mazur, A, Hiller, S. | Deposit date: | 2017-09-01 | Release date: | 2017-11-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The dynamic dimer structure of the chaperone Trigger Factor. Nat Commun, 8, 2017
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5OMP
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![BU of 5omp by Molmil](/molmil-images/mine/5omp) | Human FKBP5 protein | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP5, SULFATE ION | Authors: | Kumar, R, Moche, M, Winblad, B, Pavlov, P. | Deposit date: | 2017-08-01 | Release date: | 2017-11-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51. Sci Rep, 7, 2017
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5OWI
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![BU of 5owi by Molmil](/molmil-images/mine/5owi) | The dynamic dimer structure of the chaperone Trigger Factor (conformer 1) | Descriptor: | Trigger factor | Authors: | Morgado, L, Burmann, B.M, Sharpe, T, Mazur, A, Hiller, S. | Deposit date: | 2017-09-01 | Release date: | 2017-11-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The dynamic dimer structure of the chaperone Trigger Factor. Nat Commun, 8, 2017
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6JRS
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![BU of 6jrs by Molmil](/molmil-images/mine/6jrs) | Structure of RyR2 (*F/A/C/L-Ca2+/Ca2+-CaM dataset) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... | Authors: | Gong, D.S, Chi, X.M, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Yan, N. | Deposit date: | 2019-04-05 | Release date: | 2019-07-17 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Modulation of cardiac ryanodine receptor 2 by calmodulin. Nature, 572, 2019
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1KT1
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![BU of 1kt1 by Molmil](/molmil-images/mine/1kt1) | Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes | Descriptor: | FK506-binding protein FKBP51, SULFATE ION | Authors: | Sinars, C.R, Cheung-Flynn, J, Rimerman, R.A, Scammell, J.G, Smith, D.F, Clardy, J.C. | Deposit date: | 2002-01-14 | Release date: | 2003-02-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | STRUCTURE OF THE LARGE FK506-BINDING PROTEIN FKBP51, AN HSP90-BINDING PROTEIN AND A COMPONENT OF STEROID RECEPTOR COMPLEXES Proc.Natl.Acad.Sci.USA, 100, 2003
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3MDY
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![BU of 3mdy by Molmil](/molmil-images/mine/3mdy) | Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189 | Descriptor: | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, Bone morphogenetic protein receptor type-1B, Peptidyl-prolyl cis-trans isomerase FKBP1A | Authors: | Chaikuad, A, Sanvitale, C, Mahajan, P, Daga, N, Cooper, C, Krojer, T, Alfano, I, Knapp, S, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC) | Deposit date: | 2010-03-31 | Release date: | 2010-05-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189 To be Published
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1NSG
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![BU of 1nsg by Molmil](/molmil-images/mine/1nsg) | THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP | Descriptor: | C49-METHYL RAPAMYCIN, FK506-BINDING PROTEIN, FKBP-RAPAMYCIN ASSOCIATED PROTEIN (FRAP) | Authors: | Liang, J, Choi, J, Clardy, J. | Deposit date: | 1997-07-01 | Release date: | 1998-03-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution. Acta Crystallogr.,Sect.D, 55, 1999
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6M4V
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![BU of 6m4v by Molmil](/molmil-images/mine/6m4v) | Crystal structure of MBP fused split FKBP in complex with rapamycin | Descriptor: | GLYCEROL, Peptidyl-prolyl cis-trans isomerase FKBP1A, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, ... | Authors: | Kikuchi, M, Wu, D, Inoue, T, Umehara, T. | Deposit date: | 2020-03-09 | Release date: | 2020-08-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Rational design and implementation of a chemically inducible heterotrimerization system. Nat.Methods, 17, 2020
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6M4U
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![BU of 6m4u by Molmil](/molmil-images/mine/6m4u) | Crystal structure of FKBP-FRB T2098L mutant in complex with rapamycin | Descriptor: | CHLORIDE ION, GLYCEROL, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | Authors: | Kikuchi, M, Wu, D, Inoue, T, Umehara, T. | Deposit date: | 2020-03-09 | Release date: | 2020-08-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Rational design and implementation of a chemically inducible heterotrimerization system. Nat.Methods, 17, 2020
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6M4W
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![BU of 6m4w by Molmil](/molmil-images/mine/6m4w) | Crystal structure of MBP fused split FKBP-FRB T2098L mutant in complex with rapamycin | Descriptor: | GLYCEROL, Peptidyl-prolyl cis-trans isomerase FKBP1A, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, ... | Authors: | Kikuchi, M, Wu, D, Inoue, T, Umehara, T. | Deposit date: | 2020-03-09 | Release date: | 2020-08-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | Rational design and implementation of a chemically inducible heterotrimerization system. Nat.Methods, 17, 2020
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3J8H
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![BU of 3j8h by Molmil](/molmil-images/mine/3j8h) | Structure of the rabbit ryanodine receptor RyR1 in complex with FKBP12 at 3.8 Angstrom resolution | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1A, Ryanodine receptor 1, ZINC ION | Authors: | Yan, Z, Bai, X, Yan, C, Wu, J, Scheres, S.H.W, Shi, Y, Yan, N. | Deposit date: | 2014-10-26 | Release date: | 2014-12-10 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. Nature, 517, 2015
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6M2W
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![BU of 6m2w by Molmil](/molmil-images/mine/6m2w) | Structure of RyR1 (Ca2+/Caffeine/ATP/CaM1234/CHL) | Descriptor: | 5-bromanyl-N-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, ... | Authors: | Ma, R, Haji-Ghassemi, O, Ma, D, Lin, L, Samurkas, A, Van Petegem, F, Yuchi, Z. | Deposit date: | 2020-03-01 | Release date: | 2020-09-02 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis for diamide modulation of ryanodine receptor. Nat.Chem.Biol., 16, 2020
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1KT0
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![BU of 1kt0 by Molmil](/molmil-images/mine/1kt0) | Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes | Descriptor: | 51 KDA FK506-BINDING PROTEIN, SULFATE ION | Authors: | Sinars, C.R, Cheung-Flynn, J, Rimerman, R.A, Scammell, J.G, Smith, D.F, Clardy, J.C. | Deposit date: | 2002-01-14 | Release date: | 2003-02-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a
component of steroid receptor complexes Proc.Natl.Acad.Sci.USA, 100, 2003
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1P5Q
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![BU of 1p5q by Molmil](/molmil-images/mine/1p5q) | Crystal Structure of FKBP52 C-terminal Domain | Descriptor: | FK506-binding protein 4, SULFATE ION | Authors: | Wu, B, Li, P, Lou, Z, Shu, C, Ding, Y, Shen, B, Rao, Z. | Deposit date: | 2003-04-28 | Release date: | 2004-06-22 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | 3D structure of human FK506-binding protein 52: Implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex Proc.Natl.Acad.Sci.USA, 101, 2004
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8DUJ
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![BU of 8duj by Molmil](/molmil-images/mine/8duj) | |
8DVE
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![BU of 8dve by Molmil](/molmil-images/mine/8dve) | |
8DVV
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![BU of 8dvv by Molmil](/molmil-images/mine/8dvv) | Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under open-state conditions | Descriptor: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... | Authors: | Iyer, K.A, Hu, Y, Murayama, T, Samso, M. | Deposit date: | 2022-07-29 | Release date: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under open-state conditions To Be Published
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8DTY
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![BU of 8dty by Molmil](/molmil-images/mine/8dty) | |
8DTZ
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![BU of 8dtz by Molmil](/molmil-images/mine/8dtz) | |
2FAP
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![BU of 2fap by Molmil](/molmil-images/mine/2fap) | THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-(C16)-ETHOXY RAPAMYCIN COMPLEX INTERACTING WITH HUMA | Descriptor: | C49-METHYL RAPAMYCIN, FK506-BINDING PROTEIN, FRAP | Authors: | Liang, J, Choi, J, Clardy, J. | Deposit date: | 1998-09-22 | Release date: | 1999-05-18 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution. Acta Crystallogr.,Sect.D, 55, 1999
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8ERA
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![BU of 8era by Molmil](/molmil-images/mine/8era) | RMC-5552 in complex with mTORC1 and FKBP12 | Descriptor: | (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, 1-[6-{[(3M)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1H)-yl]-3-hydroxypropan-1-one, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | Authors: | Tomlinson, A.C.A, Yano, J.K. | Deposit date: | 2022-10-11 | Release date: | 2022-12-28 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors. J.Med.Chem., 66, 2023
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