3MDY

Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189

Summary for 3MDY

• Entry DOI: 10.2210/pdb3mdy/pdb
• Descriptor: Bone morphogenetic protein receptor type-1B, Peptidyl-prolyl cis-trans isomerase FKBP1A, 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, ... (4 entities in total)
• Functional Keywords: complex (isomerase-protein kinase), receptor serine/threonine kinase, structural genomics consortium, sgc, atp-binding, disease mutation, kinase, transferase, rotamase, transferase-isomerase complex, transferase/isomerase
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: O00238; Cytoplasm: P62942
• Total number of polymer chains: 4
• Total formula weight: 101552.68

Authors

Chaikuad, A.,Sanvitale, C.,Mahajan, P.,Daga, N.,Cooper, C.,Krojer, T.,Alfano, I.,Knapp, S.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2010-03-31, release date: 2010-05-19, Last modification date: 2023-11-01)

• Primary citation: Chaikuad, A.,Sanvitale, C.,Mahajan, P.,Daga, N.,Cooper, C.,Krojer, T.,Alfano, I.,Knapp, S.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC); Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189; To be Published,

Experimental method

X-RAY DIFFRACTION (2.05 Å)