3MDY
Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | Bone morphogenetic protein receptor type-1B | polymer | 337 | 38315.1 | 2 | UniProt (O00238) Pfam (PF08515) Pfam (PF07714) | Homo sapiens (human) | BMPR1B, BMP type-1B receptor, BMPR-1B |
| 2 | C, D (B, D) | Peptidyl-prolyl cis-trans isomerase FKBP1A | polymer | 109 | 12054.8 | 2 | UniProt (P62942) Pfam (PF00254) | Homo sapiens (human) | FKBP12, PPIase FKBP1A, FK506-binding protein 1A, FKBP-1A, Rotamase, Immunophilin FKBP12, 12 kDa FK506-binding protein, 12 kDa FKBP, FKBP-12 |
| 3 | E, F (A, C) | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | non-polymer | 406.5 | 2 | Chemie (LDN) | |||
| 4 | G, H, I, J (A, C, B, D) | water | water | 18.0 | 687 | Chemie (HOH) |
Sequence modifications
A, C: 168 - 502 (UniProt: O00238)
B, D: 1 - 108 (UniProt: P62942)
| PDB | External Database | Details |
|---|---|---|
| Ser 166 | - | expression tag |
| Met 167 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 100739.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 813.0 | |
| All* | Total formula weight | 101552.7 |
