5I5M
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![BU of 5i5m by Molmil](/molmil-images/mine/5i5m) | Shewanella denitrificans nitrous oxide reductase, Ca2+-reconstituted form | Descriptor: | (R,R)-2,3-BUTANEDIOL, CALCIUM ION, Nitrous-oxide reductase, ... | Authors: | Schneider, L.K, Einsle, O. | Deposit date: | 2016-02-15 | Release date: | 2016-03-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.37 Å) | Cite: | Role of Calcium in Secondary Structure Stabilization during Maturation of Nitrous Oxide Reductase. Biochemistry, 55, 2016
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6HMQ
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![BU of 6hmq by Molmil](/molmil-images/mine/6hmq) | STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 GENE PRODUCT) IN COMPLEX WITH THE BENZOTRIAZOLE-TYPE INHIBITOR MB002 | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol, ... | Authors: | Niefind, K, Lindenblatt, D, Applegate, V.M, Jose, J, Le Borgne, M. | Deposit date: | 2018-09-12 | Release date: | 2019-03-27 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (0.97 Å) | Cite: | Diacritic Binding of an Indenoindole Inhibitor by CK2 alpha Paralogs Explored by a Reliable Path to Atomic Resolution CK2 alpha ' Structures. Acs Omega, 4, 2019
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6D32
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![BU of 6d32 by Molmil](/molmil-images/mine/6d32) | Crystal structure of Xenopus Smoothened in complex with cyclopamine | Descriptor: | Cyclopamine, Smoothened,Soluble cytochrome b562,Smoothened | Authors: | Huang, P, Zheng, S, Kim, Y, Kruse, A.C, Salic, A. | Deposit date: | 2018-04-14 | Release date: | 2018-05-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.751 Å) | Cite: | Structural Basis of Smoothened Activation in Hedgehog Signaling. Cell, 174, 2018
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7LOX
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![BU of 7lox by Molmil](/molmil-images/mine/7lox) | The structure of Agmatinase from E. Coli at 3.2 A displaying guanidine in the active site | Descriptor: | Agmatinase, GUANIDINE, MANGANESE (II) ION | Authors: | Maturana, P, Figueroa, M, Gonzalez-Ordenes, F, Villalobos, P, Martinez-Oyanedel, J, Uribe, E.A, Castro-Fernandez, V. | Deposit date: | 2021-02-11 | Release date: | 2021-05-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal Structure of Escherichia coli Agmatinase: Catalytic Mechanism and Residues Relevant for Substrate Specificity. Int J Mol Sci, 22, 2021
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7LUO
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![BU of 7luo by Molmil](/molmil-images/mine/7luo) | N-terminus of Skp2 bound to Cyclin A | Descriptor: | S-phase kinase-associated protein 2,Cyclin-A2, Skp2 Motif 1 uncharacterized fragment 1, Skp2 Motif 1 uncharacterized fragment 2 | Authors: | Kelso, S, Ceccarelli, D.F, Sicheri, F. | Deposit date: | 2021-02-22 | Release date: | 2021-05-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.17 Å) | Cite: | Bipartite binding of the N terminus of Skp2 to cyclin A. Structure, 29, 2021
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5IEH
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![BU of 5ieh by Molmil](/molmil-images/mine/5ieh) | |
6HNL
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![BU of 6hnl by Molmil](/molmil-images/mine/6hnl) | Selenomethionine derivative of IdmH 96-104 loop truncation variant | Descriptor: | Putative polyketide cyclase IdmH | Authors: | Drulyte, I, Obajdin, J, Trinh, C, Hemsworth, G.R, Berry, A. | Deposit date: | 2018-09-16 | Release date: | 2019-11-06 | Last modified: | 2019-11-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the putative cyclase IdmH from the indanomycin nonribosomal peptide synthase/polyketide synthase. Iucrj, 6, 2019
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5UC7
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![BU of 5uc7 by Molmil](/molmil-images/mine/5uc7) | Crystal structure of BioA / 7,8-diaminopelargonic acid aminotransferase / DAPA synthase from Citrobacter rodentium, PLP complex | Descriptor: | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, D(-)-TARTARIC ACID | Authors: | Stogios, P.J, Evdokimova, E, Di Leo, R, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2016-12-21 | Release date: | 2017-01-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.835 Å) | Cite: | Crystal structure of BioA / 7,8-diaminopelargonic acid aminotransferase / DAPA synthase from Citrobacter rodentium, PLP complex To Be Published
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7LRQ
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![BU of 7lrq by Molmil](/molmil-images/mine/7lrq) | Crystal structure of human SFPQ/NONO heterodimer, conserved DBHS region | Descriptor: | CHLORIDE ION, Non-POU domain-containing octamer-binding protein, Splicing factor, ... | Authors: | Marshall, A.C, Bond, C.S, Mohnen, I. | Deposit date: | 2021-02-17 | Release date: | 2021-05-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Paraspeckle subnuclear bodies depend on dynamic heterodimerisation of DBHS RNA-binding proteins via their structured domains. J.Biol.Chem., 298, 2022
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6HVO
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![BU of 6hvo by Molmil](/molmil-images/mine/6hvo) | Crystal structure of human PCNA in complex with three peptides of p12 subunit of human polymerase delta | Descriptor: | DNA polymerase delta subunit 4, Proliferating cell nuclear antigen, SULFATE ION | Authors: | Gonzalez-Magana, A, Romano-Moreno, M, Rojas, A.L, Blanco, F.J, De Biasio, A. | Deposit date: | 2018-10-11 | Release date: | 2019-01-23 | Last modified: | 2019-03-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The p12 subunit of human polymerase delta uses an atypical PIP box for molecular recognition of proliferating cell nuclear antigen (PCNA). J.Biol.Chem., 294, 2019
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7LRU
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![BU of 7lru by Molmil](/molmil-images/mine/7lru) | Crystal structure of SFPQ-NONO-SFPQ chimeric protein homodimer | Descriptor: | Splicing factor, proline- and glutamine-rich,Isoform 2 of Non-POU domain-containing octamer-binding protein,Isoform Short of Splicing factor, proline- and glutamine-rich | Authors: | Marshall, A.C, Bond, C.S, Mohnen, I, Knott, G.J. | Deposit date: | 2021-02-17 | Release date: | 2021-05-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of SFPQ-NONO-SFPQ chimeric protein homodimer To Be Published
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5I0S
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![BU of 5i0s by Molmil](/molmil-images/mine/5i0s) | Thiosulfate bound Cysteine Dioxygenase at pH 6.2 | Descriptor: | Cysteine dioxygenase type 1, FE (III) ION, THIOSULFATE | Authors: | Kean, K.M, Driggers, C.M, Karplus, P.A. | Deposit date: | 2016-02-04 | Release date: | 2016-12-14 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
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7LOL
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![BU of 7lol by Molmil](/molmil-images/mine/7lol) | The structure of Agmatinase from E. Coli at 1.8 A displaying urea and agmatine | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AGMATINE, Agmatinase, ... | Authors: | Maturana, P, Figueroa, M, Gonzalez-Ordenes, F, Villalobos, P, Martinez-Oyanedel, J, Uribe, E.A, Castro-Fernandez, V. | Deposit date: | 2021-02-10 | Release date: | 2021-05-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of Escherichia coli Agmatinase: Catalytic Mechanism and Residues Relevant for Substrate Specificity. Int J Mol Sci, 22, 2021
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5TRV
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![BU of 5trv by Molmil](/molmil-images/mine/5trv) | Crystal structure of a de novo designed protein with curved beta-sheet | Descriptor: | DI(HYDROXYETHYL)ETHER, denovo NTF2 | Authors: | Basanta, B, Oberdorfer, G, Marcos, E, Chidyausiku, T.M, Sankaran, B, Baker, D. | Deposit date: | 2016-10-27 | Release date: | 2017-01-25 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Principles for designing proteins with cavities formed by curved beta sheets. Science, 355, 2017
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6HXQ
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5I9S
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![BU of 5i9s by Molmil](/molmil-images/mine/5i9s) | MicroED structure of proteinase K at 1.75 A resolution | Descriptor: | Proteinase K, SULFATE ION | Authors: | Hattne, J, Shi, D, de la Cruz, M.J, Reyes, F.E, Gonen, T. | Deposit date: | 2016-02-20 | Release date: | 2016-06-08 | Last modified: | 2023-08-30 | Method: | ELECTRON CRYSTALLOGRAPHY (1.75 Å) | Cite: | Modeling truncated pixel values of faint reflections in MicroED images. J.Appl.Crystallogr., 49, 2016
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6HYC
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![BU of 6hyc by Molmil](/molmil-images/mine/6hyc) | |
7LNO
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![BU of 7lno by Molmil](/molmil-images/mine/7lno) | Structure of apo-CDD-1 beta-lactamase in imidazole and MPD | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Beta-lactamase, SULFATE ION | Authors: | Smith, C.A, Vakulenko, S.B, Stewart, N.K. | Deposit date: | 2021-02-08 | Release date: | 2021-05-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | In Crystallo Time-Resolved Interaction of the Clostridioides difficile CDD-1 enzyme with Avibactam Provides New Insights into the Catalytic Mechanism of Class D beta-lactamases. Acs Infect Dis., 7, 2021
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6HQ9
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![BU of 6hq9 by Molmil](/molmil-images/mine/6hq9) | Crystal structure of the Tudor domain of human ERCC6-L2 | Descriptor: | DNA excision repair protein ERCC-6-like 2 | Authors: | Newman, J.A, Gavard, A.E, Nathan, W.J, Pinkas, D.M, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | Deposit date: | 2018-09-24 | Release date: | 2018-10-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.982 Å) | Cite: | Crystal structure of the Tudor domain of human ERCC6-L2 To Be Published
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7LNQ
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![BU of 7lnq by Molmil](/molmil-images/mine/7lnq) | Structure of the avibactam-CDD-1 3 minute complex in imidazole and MPD | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, (4S)-2-METHYL-2,4-PENTANEDIOL, Beta-lactamase, ... | Authors: | Smith, C.A, Vakulenko, S.B, Stewart, N.K. | Deposit date: | 2021-02-08 | Release date: | 2021-05-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | In Crystallo Time-Resolved Interaction of the Clostridioides difficile CDD-1 enzyme with Avibactam Provides New Insights into the Catalytic Mechanism of Class D beta-lactamases. Acs Infect Dis., 7, 2021
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6HQD
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![BU of 6hqd by Molmil](/molmil-images/mine/6hqd) | Cytochrome P450-153 from Pseudomonas sp. 19-rlim | Descriptor: | Cytochrome P450, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Fiorentini, F, Mattevi, A. | Deposit date: | 2018-09-24 | Release date: | 2018-12-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Extreme Structural Plasticity in the CYP153 Subfamily of P450s Directs Development of Designer Hydroxylases. Biochemistry, 57, 2018
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6CMC
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5UL1
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![BU of 5ul1 by Molmil](/molmil-images/mine/5ul1) | The co-structure of 3-amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide and a rationally designed PI3K-alpha mutant that mimics ATR | Descriptor: | 3-amino-6-(4-{[(2S)-1-(dimethylamino)propan-2-yl]sulfonyl}phenyl)-N-phenylpyrazine-2-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Authors: | Knapp, M.S, Elling, R.A, Mamo, M. | Deposit date: | 2017-01-23 | Release date: | 2017-05-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Rationally Designed PI3K alpha Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors. J. Mol. Biol., 429, 2017
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5I2U
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![BU of 5i2u by Molmil](/molmil-images/mine/5i2u) | Crystal structure of a novel Halo-Tolerant Cellulase from Soil Metagenome | Descriptor: | Cellulase, GLYCEROL, MAGNESIUM ION, ... | Authors: | Garg, R, Brahma, V, Srivastava, R, Verma, L, Karthikeyan, S, Sahni, G. | Deposit date: | 2016-02-09 | Release date: | 2017-01-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Biochemical and structural characterization of a novel halotolerant cellulase from soil metagenome Sci Rep, 6, 2016
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6CMQ
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![BU of 6cmq by Molmil](/molmil-images/mine/6cmq) | Structure of human SHP2 without N-SH2 domain | Descriptor: | Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. | Deposit date: | 2018-03-06 | Release date: | 2018-11-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
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