5ISO
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![BU of 5iso by Molmil](/molmil-images/mine/5iso) | STRUCTURE OF FULL LENGTH HUMAN AMPK (NON-PHOSPHORYLATED AT T-LOOP) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A BENZIMIDAZOLE DERIVATIVE (991) | Descriptor: | 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... | Authors: | Xiao, B, Hubbard, J.A, Gamblin, S.J. | Deposit date: | 2016-03-15 | Release date: | 2017-03-29 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | STRUCTURE OF FULL LENGTH HUMAN AMPK (NON-PHOSPHORYLATED AT T-LOOP) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A BENZIMIDAZOLE DERIVATIVE (991) To Be Published
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5K24
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![BU of 5k24 by Molmil](/molmil-images/mine/5k24) | |
4L27
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![BU of 4l27 by Molmil](/molmil-images/mine/4l27) | Crystal structure of delta1-39 and delta516-525 human cystathionine beta-synthase D444N mutant containing C-terminal 6xHis tag | Descriptor: | Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Ereno, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez, L.A. | Deposit date: | 2013-06-04 | Release date: | 2013-09-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.391 Å) | Cite: | Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration. Proc.Natl.Acad.Sci.USA, 110, 2013
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4L3V
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![BU of 4l3v by Molmil](/molmil-images/mine/4l3v) | Crystal structure of delta516-525 human cystathionine beta-synthase | Descriptor: | Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Ereno, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez, L.A. | Deposit date: | 2013-06-07 | Release date: | 2013-09-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.628 Å) | Cite: | Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration. Proc.Natl.Acad.Sci.USA, 110, 2013
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4L28
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![BU of 4l28 by Molmil](/molmil-images/mine/4l28) | Crystal structure of delta516-525 human cystathionine beta-synthase D444N mutant containing C-terminal 6xHis tag | Descriptor: | Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Ereno, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez, L.A. | Deposit date: | 2013-06-04 | Release date: | 2013-09-18 | Last modified: | 2013-10-16 | Method: | X-RAY DIFFRACTION (2.626 Å) | Cite: | Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration. Proc.Natl.Acad.Sci.USA, 110, 2013
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4L0D
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![BU of 4l0d by Molmil](/molmil-images/mine/4l0d) | Crystal structure of delta516-525 human cystathionine beta-synthase containing C-terminal 6xHis-tag | Descriptor: | Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Ereno, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez-Cruz, L.A. | Deposit date: | 2013-05-31 | Release date: | 2013-09-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.97 Å) | Cite: | Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration. Proc.Natl.Acad.Sci.USA, 110, 2013
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6Z3S
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![BU of 6z3s by Molmil](/molmil-images/mine/6z3s) | Crystal structure of delta466-491 cystathionine beta-synthase from Toxoplasma gondii with O-Acetylserine | Descriptor: | 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Cystathionine beta-synthase | Authors: | Fernandez-Rodriguez, C, Oyenarte, I, Conter, C, Gonzalez-Recio, I, Quintana, I, Martinez-Chantar, M, Astegno, A, Martinez-Cruz, L.A. | Deposit date: | 2020-05-21 | Release date: | 2021-06-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.048 Å) | Cite: | Structural insight into the unique conformation of cystathionine beta-synthase from Toxoplasma gondii . Comput Struct Biotechnol J, 19, 2021
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1ME7
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![BU of 1me7 by Molmil](/molmil-images/mine/1me7) | Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with RVP and MOA bound | Descriptor: | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, MYCOPHENOLIC ACID, POTASSIUM ION, ... | Authors: | Prosise, G.L, Wu, J, Luecke, H. | Deposit date: | 2002-08-08 | Release date: | 2003-01-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal Structure of Tritrichomonas foetus Inosine Monophosphate Dehydrogenase
in Complex with the Inhibitor Ribavirin Monophosphate Reveals a Catalysis-dependent
Ion-binding Site J.Biol.Chem., 277, 2002
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1ME9
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![BU of 1me9 by Molmil](/molmil-images/mine/1me9) | |
1MEW
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![BU of 1mew by Molmil](/molmil-images/mine/1mew) | |
6ZS7
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![BU of 6zs7 by Molmil](/molmil-images/mine/6zs7) | Crystal structure of delta466-491 cystathionine beta-synthase from Toxoplasma gondii with L-cysteine | Descriptor: | 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Cystathionine beta-synthase | Authors: | Fernandez-Rodriguez, C, Oyenarte, I, Conter, C, Gonzalez-Recio, I, Quintana, I, Martinez-Chantar, M, Astegno, A, Martinez-Cruz, L.A. | Deposit date: | 2020-07-15 | Release date: | 2021-07-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural insight into the unique conformation of cystathionine beta-synthase from Toxoplasma gondii . Comput Struct Biotechnol J, 19, 2021
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7AHD
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![BU of 7ahd by Molmil](/molmil-images/mine/7ahd) | OpuA (E190Q) occluded | Descriptor: | ABC transporter permease subunit, ABC-type proline/glycine betaine transport system ATPase component, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Sikkema, H.R, Rheinberger, J, Paulino, C, Poolman, B. | Deposit date: | 2020-09-24 | Release date: | 2020-11-25 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA. Sci Adv, 6, 2020
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7AHH
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![BU of 7ahh by Molmil](/molmil-images/mine/7ahh) | OpuA inhibited inward-facing, SBD docked | Descriptor: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, ABC transporter permease subunit, ABC-type proline/glycine betaine transport system ATPase component, ... | Authors: | Sikkema, H.R, Rheinberger, J, Paulino, C, Poolman, B. | Deposit date: | 2020-09-24 | Release date: | 2020-11-25 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA. Sci Adv, 6, 2020
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7AHE
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![BU of 7ahe by Molmil](/molmil-images/mine/7ahe) | OpuA inhibited inward facing | Descriptor: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, ABC transporter permease subunit, ABC-type proline/glycine betaine transport system ATPase component | Authors: | Sikkema, H.R, Rheinberger, J, Paulino, C, Poolman, B. | Deposit date: | 2020-09-24 | Release date: | 2020-11-25 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA. Sci Adv, 6, 2020
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7AHC
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![BU of 7ahc by Molmil](/molmil-images/mine/7ahc) | OpuA apo inward-facing | Descriptor: | ABC transporter permease subunit, ABC-type proline/glycine betaine transport system ATPase component | Authors: | Sikkema, H.R, Rheinberger, J, Paulino, C, Poolman, B. | Deposit date: | 2020-09-24 | Release date: | 2020-11-25 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA. Sci Adv, 6, 2020
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1NFB
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![BU of 1nfb by Molmil](/molmil-images/mine/1nfb) | |
1MEI
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![BU of 1mei by Molmil](/molmil-images/mine/1mei) | |
1MEH
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![BU of 1meh by Molmil](/molmil-images/mine/1meh) | |
1ME8
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![BU of 1me8 by Molmil](/molmil-images/mine/1me8) | Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with RVP bound | Descriptor: | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, POTASSIUM ION, RIBAVIRIN MONOPHOSPHATE, ... | Authors: | Prosise, G.L, Wu, J, Luecke, H. | Deposit date: | 2002-08-08 | Release date: | 2003-01-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structure of Tritrichomonas foetus Inosine Monophosphate Dehydrogenase
in Complex with the Inhibitor Ribavirin Monophosphate Reveals a
Catalysis-dependent Ion-binding Site J.Biol.Chem., 277, 2002
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1NF7
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![BU of 1nf7 by Molmil](/molmil-images/mine/1nf7) | |
6U8N
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![BU of 6u8n by Molmil](/molmil-images/mine/6u8n) | Human IMPDH2 treated with ATP, IMP, and NAD+. Fully extended filament segment reconstruction. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 2, ... | Authors: | Johnson, M.C, Kollman, J.M. | Deposit date: | 2019-09-05 | Release date: | 2020-03-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9, 2020
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6UDQ
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![BU of 6udq by Molmil](/molmil-images/mine/6udq) | Human IMPDH2 treated with ATP, IMP, and 20 mM GTP. Fully compressed filament end reconstruction. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | Authors: | Johnson, M.C, Kollman, J.M. | Deposit date: | 2019-09-19 | Release date: | 2020-03-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9, 2020
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6U8E
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![BU of 6u8e by Molmil](/molmil-images/mine/6u8e) | |
6UDO
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![BU of 6udo by Molmil](/molmil-images/mine/6udo) | Human IMPDH2 treated with ATP, IMP, and 20 mM GTP. Fully compressed filament segment reconstruction. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | Authors: | Johnson, M.C, Kollman, J.M. | Deposit date: | 2019-09-19 | Release date: | 2020-03-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9, 2020
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6UDP
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![BU of 6udp by Molmil](/molmil-images/mine/6udp) | |