PDB: 534 resultsInfo pagesStatus searchChemie searchBIRD

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3VS3	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Descriptor: 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... Authors: Kuratani, M, Tomaebchi, Y, Handa, N, Yokoyama, S. Deposit date: 2012-04-21 Release date: 2013-05-01 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.17 Å) Cite: A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS6	Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor tert-butyl {4-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate Descriptor: CALCIUM ION, CHLORIDE ION, Tyrosine-protein kinase HCK, ... Authors: Kuratani, M, Honda, K, Tomabechi, Y, Toyama, M, Handa, N, Yokoyama, S. Deposit date: 2012-04-21 Release date: 2013-05-01 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.373 Å) Cite: A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS5	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Descriptor: 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, Tyrosine-protein kinase HCK Authors: Kuratani, M, Tomabechi, Y, Handa, N, Yokoyama, S. Deposit date: 2012-04-21 Release date: 2013-05-01 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.851 Å) Cite: A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS2	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Descriptor: 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... Authors: Kuratani, M, Tomabechi, Y, Niwa, H, Parker, J.L, Handa, N, Yokoyama, S. Deposit date: 2012-04-21 Release date: 2013-05-01 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.609 Å) Cite: A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VRY	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane Descriptor: 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane, CALCIUM ION, CHLORIDE ION, ... Authors: Kuratani, M, Tomabechi, Y, Niwa, H, Handa, N, Yokoyama, S. Deposit date: 2012-04-21 Release date: 2013-05-01 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.481 Å) Cite: A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
4EIK	Crystal Structure of the Human Fyn SH3 domain in complex with the synthetic peptide VSL12 Descriptor: SODIUM ION, Tyrosine-protein kinase Fyn, VSL12 peptide Authors: Camara-Artigas, A. Deposit date: 2012-04-05 Release date: 2013-04-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystallization of and selenomethionine phasing strategy for a SETMAR-DNA complex. Acta Crystallogr F Struct Biol Commun, 72, 2016
2LQW	Solution structure of phosphorylated CRKL Descriptor: Crk-like protein Authors: Jankowski, W, Saleh, T, Kalodimos, C. Deposit date: 2012-03-16 Release date: 2012-05-16 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII. Nat.Chem.Biol., 8, 2012
2LQN	Solution structure of CRKL Descriptor: Crk-like protein Authors: Jankowski, W, Saleh, T, Kalodimos, C. Deposit date: 2012-03-09 Release date: 2012-05-16 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII. Nat.Chem.Biol., 8, 2012
2LP5	Native Structure of the Fyn SH3 A39V/N53P/V55L Descriptor: Tyrosine-protein kinase Fyn Authors: Neudecker, P, Robustelli, P, Cavalli, A, Vendruscolo, M, Kay, L.E. Deposit date: 2012-02-06 Release date: 2012-05-16 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structure of an intermediate state in protein folding and aggregation. Science, 336, 2012
4D8D	Crystal structure of HIV-1 NEF Fyn-SH3 R96W variant Descriptor: GLYCEROL, Protein Nef, Tyrosine-protein kinase Fyn Authors: Arold, S.T, Hoh, F, Dumas, C. Deposit date: 2012-01-10 Release date: 2013-01-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.5201 Å) Cite: Synergy and allostery in ligand binding by HIV-1 Nef. Biochem.J., 478, 2021
4D8K	Crystal structure of a SH3-SH2 domains of a lymphocyte-specific protein tyrosine kinase (LCK) from Homo sapiens at 2.36 A resolution Descriptor: GLYCEROL, SULFATE ION, Tyrosine-protein kinase Lck Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2012-01-10 Release date: 2012-01-25 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.36 Å) Cite: Crystal structure of a SH3-SH2 domains of a lymphocyte-specific protein tyrosine kinase (LCK) from Homo sapiens at 2.36 A resolution To be published
2LMJ	Itk-sh3 Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Kristiansen, P, Bie Andersen, T, Huszenicza, Z, Andreotti, A.H, Spurkland, A. Deposit date: 2011-12-05 Release date: 2012-12-05 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: The SH3 domains of the Tec family kinase Itk and the Src family kinase Lck compete for adjacent sites on T-cell specific adapter protein To be Published
4A63	Crystal structure of the p73-ASPP2 complex at 2.6A resolution Descriptor: ACETATE ION, APOPTOSIS STIMULATING OF P53 PROTEIN 2, TUMOUR PROTEIN 73, ... Authors: Canning, P, Sharpe, T, Krojer, T, Savitsky, P, Cooper, C.D.O, Salah, E, Keates, T, Muniz, J, Vollmar, M, von Delft, F, Weigelt, J, Arrowsmith, C, Bountra, C, Edwards, A, Bullock, A.N. Deposit date: 2011-10-31 Release date: 2011-12-21 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Structural Basis for Aspp2 Recognition by the Tumor Suppressor P73. J.Mol.Biol., 423, 2012
3UF4	Crystal structure of a SH3 and SH2 domains of FYN protein (Proto-concogene Tyrosine-protein kinase Fyn) from Mus musculus at 1.98 A resolution Descriptor: CHLORIDE ION, GLYCEROL, SODIUM ION, ... Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2011-10-31 Release date: 2011-12-07 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Crystal structure of a SH3 and SH2 domains of FYN protein (Proto-concogene Tyrosine-protein kinase Fyn) from Mus musculus at 1.98 A resolution To be published
3UAT	Guanylate Kinase Domains of the MAGUK Family Scaffold Proteins as Specific Phospho-Protein Binding Modules Descriptor: Disks large homolog 1, phosphor-LGN peptide Authors: Shang, Y, Zhu, J, Wen, W, Zhang, M. Deposit date: 2011-10-22 Release date: 2011-12-07 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules Embo J., 2011
3UA7	Crystal Structure of the Human Fyn SH3 domain in complex with a peptide from the Hepatitis C virus NS5A-protein Descriptor: CHLORIDE ION, FORMIC ACID, GLYCEROL, ... Authors: Martin-Garcia, J.M, Ruiz-Sanz, J, Luque, I, Camara-Artigas, A. Deposit date: 2011-10-21 Release date: 2012-07-25 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The promiscuous binding of the Fyn SH3 domain to a peptide from the NS5A protein. Acta Crystallogr.,Sect.D, 68, 2012
3UA6	Crystal Structure of the Human Fyn SH3 domain Descriptor: FORMIC ACID, GLYCEROL, SODIUM ION, ... Authors: Camara-Artigas, A, Martin-Garcia, J.M. Deposit date: 2011-10-21 Release date: 2012-07-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: The promiscuous binding of the Fyn SH3 domain to a peptide from the NS5A protein. Acta Crystallogr.,Sect.D, 68, 2012
3TVT	Structural basis for Discs Large interaction with Pins Descriptor: Disks large 1 tumor suppressor protein, Partner of Inscuteable Authors: Johnston, C.A, Doe, C.Q, Prehoda, K.E. Deposit date: 2011-09-20 Release date: 2012-08-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural basis for Discs Large interaction with Pins To be Published
2LJ3	PFBD: High-throughput Strategy of Backbone fold Determination for small well-folded proteins in less than a day Descriptor: Spectrin alpha chain, brain Authors: Kumar, D, Hosur, R. Deposit date: 2011-09-04 Release date: 2011-12-07 Last modified: 2024-11-06 Method: SOLUTION NMR Cite: PFBD: High-throughput Strategy of Backbone fold Determination for small well-folded proteins in less than a day To be Published
3THK	Structure of SH3 chimera with a type II ligand linked to the chain C-terminal Descriptor: BETA-MERCAPTOETHANOL, Proline-rich peptide, SULFATE ION, ... Authors: Gabdulkhakov, A.G, Gushchina, L.V, Nikulin, A.D, Nikonov, S.V, Filimonov, V.V. Deposit date: 2011-08-19 Release date: 2011-11-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: High-Resolution Crystal Structure of Spectrin SH3 Domain Fused with a Proline-Rich Peptide. J.Biomol.Struct.Dyn., 29, 2011
2LCS	Yeast Nbp2p SH3 domain in complex with a peptide from Ste20p Descriptor: NAP1-binding protein 2, Serine/threonine-protein kinase STE20 Authors: Gorelik, M, Davidson, A.R. Deposit date: 2011-05-07 Release date: 2012-02-01 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Distinct Peptide Binding Specificities of Src Homology 3 (SH3) Protein Domains Can Be Determined by Modulation of Local Energetics across the Binding Interface. J.Biol.Chem., 287, 2012
3REA	HIV-1 Nef protein in complex with engineered Hck-SH3 domain Descriptor: Protein Nef, Tyrosine-protein kinase HCK Authors: Schulte, A, Blankenfeldt, W, Geyer, M. Deposit date: 2011-04-04 Release date: 2011-06-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. PLoS ONE, 6, 2011
3REB	HIV-1 Nef protein in complex with engineered Hck-SH3 domain Descriptor: Protein Nef, Tyrosine-protein kinase HCK Authors: Schulte, A, Blankenfeldt, W, Geyer, M. Deposit date: 2011-04-04 Release date: 2011-06-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.45 Å) Cite: Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. PLoS ONE, 6, 2011
3RBB	HIV-1 NEF protein in complex with engineered HCK SH3 domain Descriptor: 1,2-ETHANEDIOL, Protein Nef, Tyrosine-protein kinase HCK Authors: Horenkamp, F.A, Schulte, A, Weyand, M, Geyer, M. Deposit date: 2011-03-29 Release date: 2011-04-27 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Conformation of the Dileucine-Based Sorting Motif in HIV-1 Nef Revealed by Intermolecular Domain Assembly. Traffic, 12, 2011
3QWY	CED-2 Descriptor: Cell death abnormality protein 2, GLYCEROL, SULFATE ION Authors: Kang, Y, Sun, J, Liu, Y, Sun, D, Hu, Y, Liu, Y.F. Deposit date: 2011-02-28 Release date: 2011-06-08 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.52 Å) Cite: Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans. Biochem.Biophys.Res.Commun., 410, 2011

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