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PDB: 589 results

5UY7
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Crystal structure of a peptidoglycan glycosyltransferase from Burkholderia ambifaria
Descriptor: Peptidoglycan glycosyltransferase, SULFATE ION
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-02-23
Release date:2017-03-08
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of a peptidoglycan glycosyltransferase from Burkholderia ambifaria
To Be Published
2OLU
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Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Apoenzyme
Descriptor: 1,2-ETHANEDIOL, Penicillin-binding protein 2
Authors:Lovering, A.L, De Castro, L.H, Lim, D, Strynadka, N.C.
Deposit date:2007-01-19
Release date:2007-03-20
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis.
Science, 315, 2007
7LC4
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Crystal structure of Pseudomonas aeruginosa PBP3 in complex with gamma-lactam YU253911
Descriptor: 1-[(2S)-2-{[(2Z)-2-(2-amino-5-chloro-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-oxopropyl]-4-{[2-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamoyl}-2,5-dihydro-1H-pyrazole-3-carboxylic acid, Peptidoglycan D,D-transpeptidase FtsI
Authors:van den Akker, F, Kumar, V.
Deposit date:2021-01-09
Release date:2021-04-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:A gamma-lactam siderophore antibiotic effective against multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter spp.
Eur.J.Med.Chem., 220, 2021
7LQ6
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CryoEM structure of Escherichia coli PBP1b
Descriptor: Penicillin-binding protein 1B
Authors:Caveney, N.A, Workman, S.D, Yan, R, Atkinson, C.E, Yu, Z, Strynadka, N.C.J.
Deposit date:2021-02-13
Release date:2021-05-26
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:CryoEM structure of the antibacterial target PBP1b at 3.3 angstrom resolution.
Nat Commun, 12, 2021
7LY1
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Crystal structure of Pseudomonas aeruginosa PBP3 in complex with vaborbactam
Descriptor: Peptidoglycan D,D-transpeptidase FtsI, Vaborbactam
Authors:van den Akker, F, Kumar, V.
Deposit date:2021-03-05
Release date:2021-09-01
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural analysis of the boronic acid beta-lactamase inhibitor vaborbactam binding to Pseudomonas aeruginosa penicillin-binding protein 3.
Plos One, 16, 2021
7KIS
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Crystal structure of Pseudomonas aeruginosa PBP2 in complex with WCK 5153
Descriptor: (2S,5R)-1-formyl-N'-[(3R)-pyrrolidine-3-carbonyl]-5-[(sulfooxy)amino]piperidine-2-carbohydrazide, CHLORIDE ION, Peptidoglycan D,D-transpeptidase MrdA
Authors:Rajavel, M, van den Akker, F.
Deposit date:2020-10-24
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.869 Å)
Cite:Structural Characterization of Diazabicyclooctane beta-Lactam "Enhancers" in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa.
Mbio, 12, 2021
7KIW
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Crystal structure of Pseudomonas aeruginosa PBP3 in complex with zidebactam
Descriptor: (2S,5R)-1-formyl-N'-[(3R)-piperidine-3-carbonyl]-5-[(sulfooxy)amino]piperidine-2-carbohydrazide, Peptidoglycan D,D-transpeptidase FtsI
Authors:van den Akker, F, Kumar, V.
Deposit date:2020-10-25
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural Characterization of Diazabicyclooctane beta-Lactam "Enhancers" in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa.
Mbio, 12, 2021
7KIV
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Crystal structure of Pseudomonas aeruginosa PBP3 in complex with avibactam
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Peptidoglycan D,D-transpeptidase FtsI
Authors:van den Akker, F.
Deposit date:2020-10-24
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.389 Å)
Cite:Structural Characterization of Diazabicyclooctane beta-Lactam "Enhancers" in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa.
Mbio, 12, 2021
7KIT
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Crystal structure of Pseudomonas aeruginosa PBP3 in complex with WCK 4234
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carbonitrile, Peptidoglycan D,D-transpeptidase FtsI
Authors:van den Akker, F.
Deposit date:2020-10-24
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.089 Å)
Cite:Structural Characterization of Diazabicyclooctane beta-Lactam "Enhancers" in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa.
Mbio, 12, 2021
7JWL
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Crystal Structure of Pseudomonas aeruginosa Penicillin Binding Protein 3 (PAE-PBP3) bound to ETX0462
Descriptor: CHLORIDE ION, ETX0462 (Bound form), Peptidoglycan D,D-transpeptidase FtsI
Authors:Mayclin, S.J, Abendroth, J, Horanyi, P.S, Sylvester, M, Wu, X, Shapiro, A, Moussa, S, Durand-Reville, T.F.
Deposit date:2020-08-25
Release date:2021-05-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Rational design of a new antibiotic class for drug-resistant infections.
Nature, 597, 2021
7ZUI
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PENICILLIN-BINDING PROTEIN 1B (PBP-1B) in complex with lactone 5Az - Streptococcus pneumoniae R6
Descriptor: 6-azido-N-[(2R)-1-oxidanylidene-1-[[(2S,3R)-3-oxidanyl-1-oxidanylidene-butan-2-yl]amino]propan-2-yl]hexanamide, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Flanders, P.L, Contreras-Martel, C, Martins, A, Brown, N.W, Shirley, J.D, Nauta, K.M, Dessen, A, Carlson, E.E, Ambrose, E.A.
Deposit date:2022-05-12
Release date:2022-11-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Combined Structural Analysis and Molecular Dynamics Reveal Penicillin-Binding Protein Inhibition Mode with beta-Lactones.
Acs Chem.Biol., 17, 2022
7ZUK
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PENICILLIN-BINDING PROTEIN 1B (PBP-1B) in complex with lactone 7Az - Streptococcus pneumoniae R6
Descriptor: 6-azido-N-[(2S)-1-oxidanylidene-1-[[(2S,3R)-3-oxidanyl-1-oxidanylidene-butan-2-yl]amino]-3-phenyl-propan-2-yl]hexanamide, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Flanders, P.L, Contreras-Martel, C, Martins, A, Brown, N.W, Shirley, J.D, Nauta, K.M, Dessen, A, Carlson, E.E, Ambrose, E.A.
Deposit date:2022-05-12
Release date:2022-11-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.631 Å)
Cite:Combined Structural Analysis and Molecular Dynamics Reveal Penicillin-Binding Protein Inhibition Mode with beta-Lactones.
Acs Chem.Biol., 17, 2022
7ZUJ
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PENICILLIN-BINDING PROTEIN 1B (PBP-1B) in complex with lactone 6Az - Streptococcus pneumoniae R6
Descriptor: 6-azido-N-[(2S)-1-oxidanylidene-1-[[(2S,3R)-3-oxidanyl-1-oxidanylidene-butan-2-yl]amino]propan-2-yl]hexanamide, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Flanders, P.L, Contreras-Martel, C, Martins, A, Brown, N.W, Shirley, J.D, Nauta, K.M, Dessen, A, Carlson, E.E, Ambrose, E.A.
Deposit date:2022-05-12
Release date:2022-11-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Combined Structural Analysis and Molecular Dynamics Reveal Penicillin-Binding Protein Inhibition Mode with beta-Lactones.
Acs Chem.Biol., 17, 2022
7ZUH
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BU of 7zuh by Molmil
PENICILLIN-BINDING PROTEIN 1B (PBP-1B) Streptococcus pneumoniae R6
Descriptor: CHLORIDE ION, MAGNESIUM ION, Penicillin-binding protein 1b
Authors:Flanders, P.L, Contreras-Martel, C, Martins, A, Brown, N.W, Shirley, J.D, Nauta, K.M, Dessen, A, Carlson, E.E, Ambrose, E.A.
Deposit date:2022-05-12
Release date:2022-11-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.467 Å)
Cite:Combined Structural Analysis and Molecular Dynamics Reveal Penicillin-Binding Protein Inhibition Mode with beta-Lactones.
Acs Chem.Biol., 17, 2022
7ZUL
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BU of 7zul by Molmil
PENICILLIN-BINDING PROTEIN 1B (PBP-1B) in complex with 8Az lactone - Streptococcus pneumoniae R6
Descriptor: 6-azido-N-[(2R)-1-oxidanylidene-1-[[(2S,3R)-3-oxidanyl-1-oxidanylidene-butan-2-yl]amino]-3-phenyl-propan-2-yl]hexanamide, CHLORIDE ION, Penicillin-binding protein 1b
Authors:Flanders, P.L, Contreras-Martel, C, Martins, A, Brown, N.W, Shirley, J.D, Nauta, K.M, Dessen, A, Carlson, E.E, Ambrose, E.A.
Deposit date:2022-05-12
Release date:2022-11-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.744 Å)
Cite:Combined Structural Analysis and Molecular Dynamics Reveal Penicillin-Binding Protein Inhibition Mode with beta-Lactones.
Acs Chem.Biol., 17, 2022
6XV5
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BU of 6xv5 by Molmil
Crystal structure of penicillin-binding protein 2 from Yersinia pestis in complex with ertapenem
Descriptor: L(+)-TARTARIC ACID, Peptidoglycan D,D-transpeptidase MrdA
Authors:Pankov, G, Hunter, W.N, Dawson, A.
Deposit date:2020-01-21
Release date:2021-02-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.673 Å)
Cite:The structure of penicillin-binding protein 2 from Yersinia pestis
To Be Published
6Y6Z
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Structure of Pseudomonas aeruginosa Penicillin-Binding Protein 3 (PBP3) in complex with Compound 1
Descriptor: GLYCEROL, Peptidoglycan D,D-transpeptidase FtsI, ~{tert}-butyl ~{N}-[(2~{S})-2-methyl-4-oxidanyl-1-oxidanylidene-pent-4-en-2-yl]carbamate
Authors:Newman, H, Bellini, D, Dowson, C.G.
Deposit date:2020-02-27
Release date:2020-06-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
Chem Sci, 11, 2020
6YN0
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BU of 6yn0 by Molmil
Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity
Descriptor: Cell division protein FtsN, MOENOMYCIN, Penicillin-binding protein 1B
Authors:Kerff, F, Terrak, M, Boes, A, Herman, H, Charlier, P.
Deposit date:2020-04-10
Release date:2020-11-04
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The bacterial cell division protein fragment E FtsN binds to and activates the major peptidoglycan synthase PBP1b.
J.Biol.Chem., 295, 2020
8BH1
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Core divisome complex FtsWIQBL from Pseudomonas aeruginosa
Descriptor: Cell division protein FtsB, Cell division protein FtsL, Cell division protein FtsQ, ...
Authors:Kaeshammer, L, van den Ent, F, Jeffery, M, Lowe, J.
Deposit date:2022-10-28
Release date:2023-04-19
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structure of the bacterial divisome core complex and antibiotic target FtsWIQBL.
Nat Microbiol, 8, 2023
6Y6U
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Structure of Pseudomonas aeruginosa Penicillin-Binding Protein 3 (PBP3) in complex with Compound 6
Descriptor: 2-(4-hydroxyphenyl)-~{N}-[(2~{S})-2-methyl-4-oxidanyl-1-oxidanylidene-pent-4-en-2-yl]ethanamide, GLYCEROL, Peptidoglycan D,D-transpeptidase FtsI
Authors:Newman, H, Bellini, D, Dowson, C.G.
Deposit date:2020-02-27
Release date:2020-06-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion
Chem Sci, 11, 2020
8C5B
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BU of 8c5b by Molmil
Crystal Structure of Penicillin-binding Protein 3 (PBP3) from Staphylococcus Epidermidis
Descriptor: Penicillin-binding protein 3
Authors:Schwinzer, M, Brognaro, H, Rohde, H, Betzel, C.
Deposit date:2023-01-06
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and Dynamics of the Penicillin-Binding Protein 3 from Staphylococcus Epidermidis Native and in Complex with Cefotaxime and Vaborbactam
Int J Appl Biol Pharm, 2023
8C5W
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Crystal Structure of Penicillin-binding Protein 3 (PBP3) from Staphylococcus Epidermidis in complex with Cefotaxime
Descriptor: CEFOTAXIME, C3' cleaved, open, ...
Authors:Schwinzer, M, Brognaro, H, Rohde, H, Betzel, C.
Deposit date:2023-01-10
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structure and Dynamics of the Penicillin-Binding Protein 3 from Staphylococcus Epidermidis Native and in Complex with Cefotaxime and Vaborbactam
Int J Appl Biol Pharm, 2023
8C5O
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BU of 8c5o by Molmil
Crystal Structure of Penicillin-binding Protein 3 (PBP3) from Staphylococcus Epidermidis in complex with Vaborbactam
Descriptor: Penicillin-binding protein 3, Vaborbactam
Authors:Schwinzer, M, Brognaro, H, Rohde, H, Betzel, C.
Deposit date:2023-01-10
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and Dynamics of the Penicillin-Binding Protein 3 from Staphylococcus Epidermidis Native and in Complex with Cefotaxime and Vaborbactam
Int J Appl Biol Pharm, 2023
2OLV
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BU of 2olv by Molmil
Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex
Descriptor: MOENOMYCIN, Penicillin-binding protein 2
Authors:Lovering, A.L, De Castro, L, Lim, D, Strynadka, N.C.J.
Deposit date:2007-01-19
Release date:2007-03-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis.
Science, 315, 2007
4KQQ
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH (5S)-Penicilloic Acid
Descriptor: (2S,4S)-2-[(R)-carboxy{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CHLORIDE ION, GLYCEROL, ...
Authors:Nettleship, J.E, Stuart, D.I, Owens, R.J, Ren, J.
Deposit date:2013-05-15
Release date:2013-11-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3.
Acs Chem.Biol., 8, 2013

219869

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