6Y6Z

Structure of Pseudomonas aeruginosa Penicillin-Binding Protein 3 (PBP3) in complex with Compound 1

Summary for 6Y6Z

• Entry DOI: 10.2210/pdb6y6z/pdb
• Descriptor: Peptidoglycan D,D-transpeptidase FtsI, ~{tert}-butyl ~{N}-[(2~{S})-2-methyl-4-oxidanyl-1-oxidanylidene-pent-4-en-2-yl]carbamate, GLYCEROL, ... (4 entities in total)
• Functional Keywords: pbp3, penicillin binding proteins, peptidoglycan production, transpeptidation, hydrolase
• Biological source: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
• Total number of polymer chains: 1
• Total formula weight: 56936.88

Authors

Newman, H.,Bellini, D.,Dowson, C.G. (deposition date: 2020-02-27, release date: 2020-06-24, Last modification date: 2024-01-24)

• Primary citation: Kidd, S.L.,Fowler, E.,Reinhardt, T.,Compton, T.,Mateu, N.,Newman, H.,Bellini, D.,Talon, R.,McLoughlin, J.,Krojer, T.,Aimon, A.,Bradley, A.,Fairhead, M.,Brear, P.,Diaz-Saez, L.,McAuley, K.,Sore, H.F.,Madin, A.,O'Donovan, D.H.,Huber, K.V.M.,Hyvonen, M.,von Delft, F.,Dowson, C.G.,Spring, D.R.; Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.; Chem Sci, 11:10792-10801, 2020; PubMed: 34094333; DOI: 10.1039/d0sc01232g

Experimental method

X-RAY DIFFRACTION (1.7 Å)