7ZUK
PENICILLIN-BINDING PROTEIN 1B (PBP-1B) in complex with lactone 7Az - Streptococcus pneumoniae R6
This is a non-PDB format compatible entry.
Summary for 7ZUK
Entry DOI | 10.2210/pdb7zuk/pdb |
Descriptor | Penicillin-binding protein 1b, 6-azido-N-[(2S)-1-oxidanylidene-1-[[(2S,3R)-3-oxidanyl-1-oxidanylidene-butan-2-yl]amino]-3-phenyl-propan-2-yl]hexanamide, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | cell wall, peptidoglycan synthesis enzyme, infection, drug-binding protein, lactam antibiotics, transferase |
Biological source | Streptococcus pneumoniae R6 |
Total number of polymer chains | 1 |
Total formula weight | 90744.23 |
Authors | Flanders, P.L.,Contreras-Martel, C.,Martins, A.,Brown, N.W.,Shirley, J.D.,Nauta, K.M.,Dessen, A.,Carlson, E.E.,Ambrose, E.A. (deposition date: 2022-05-12, release date: 2022-11-02, Last modification date: 2024-01-31) |
Primary citation | Flanders, P.L.,Contreras-Martel, C.,Brown, N.W.,Shirley, J.D.,Martins, A.,Nauta, K.N.,Dessen, A.,Carlson, E.E.,Ambrose, E.A. Combined Structural Analysis and Molecular Dynamics Reveal Penicillin-Binding Protein Inhibition Mode with beta-Lactones. Acs Chem.Biol., 17:3110-3120, 2022 Cited by PubMed: 36173746DOI: 10.1021/acschembio.2c00503 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.631 Å) |
Structure validation
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