7ZUH

PENICILLIN-BINDING PROTEIN 1B (PBP-1B) Streptococcus pneumoniae R6

This is a non-PDB format compatible entry.

Summary for 7ZUH

• Entry DOI: 10.2210/pdb7zuh/pdb
• Descriptor: Penicillin-binding protein 1b, MAGNESIUM ION, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: cell wall, peptidoglycan synthesis enzyme, infection, drug-binding protein, lactam antibiotics, transferase
• Biological source: Streptococcus pneumoniae R6
• Total number of polymer chains: 1
• Total formula weight: 90371.86

Authors

Flanders, P.L.,Contreras-Martel, C.,Martins, A.,Brown, N.W.,Shirley, J.D.,Nauta, K.M.,Dessen, A.,Carlson, E.E.,Ambrose, E.A. (deposition date: 2022-05-12, release date: 2022-11-02, Last modification date: 2024-01-31)

• Primary citation: Flanders, P.L.,Contreras-Martel, C.,Brown, N.W.,Shirley, J.D.,Martins, A.,Nauta, K.N.,Dessen, A.,Carlson, E.E.,Ambrose, E.A.; Combined Structural Analysis and Molecular Dynamics Reveal Penicillin-Binding Protein Inhibition Mode with beta-Lactones.; Acs Chem.Biol., 17:3110-3120, 2022; PubMed: 36173746; DOI: 10.1021/acschembio.2c00503

Experimental method

X-RAY DIFFRACTION (1.467 Å)