7LC4
Crystal structure of Pseudomonas aeruginosa PBP3 in complex with gamma-lactam YU253911
Summary for 7LC4
Entry DOI | 10.2210/pdb7lc4/pdb |
Descriptor | Peptidoglycan D,D-transpeptidase FtsI, 1-[(2S)-2-{[(2Z)-2-(2-amino-5-chloro-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-oxopropyl]-4-{[2-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamoyl}-2,5-dihydro-1H-pyrazole-3-carboxylic acid (3 entities in total) |
Functional Keywords | pbp3, gamma-lactam, inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 1 |
Total formula weight | 59052.52 |
Authors | van den Akker, F.,Kumar, V. (deposition date: 2021-01-09, release date: 2021-04-28, Last modification date: 2023-10-18) |
Primary citation | Goldberg, J.A.,Kumar, V.,Spencer, E.J.,Hoyer, D.,Marshall, S.H.,Hujer, A.M.,Hujer, K.M.,Bethel, C.R.,Papp-Wallace, K.M.,Perez, F.,Jacobs, M.R.,van Duin, D.,Kreiswirth, B.N.,van den Akker, F.,Plummer, M.S.,Bonomo, R.A. A gamma-lactam siderophore antibiotic effective against multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter spp. Eur.J.Med.Chem., 220:113436-113436, 2021 Cited by PubMed: 33933754DOI: 10.1016/j.ejmech.2021.113436 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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