3BFO
| Crystal structure of Ig-like C2-type 2 domain of the human Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Descriptor: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Isoform 2) | Authors: | Walker, J.R, Akutsu, M, Littler, D.R, Li, Y, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2007-11-22 | Release date: | 2007-12-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Structure of the Ig-like C2-type 2 domain of the human Mucosa-associated lymphoid tissue lymphoma translocation protein 1. To be Published
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3UOA
| Crystal structure of the MALT1 paracaspase (P21 form) | Descriptor: | MAGNESIUM ION, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Z-Val-Arg-Pro-DL-Arg-fluoromethylketone | Authors: | Jeffrey, P.D, Yu, J.W, Shi, Y. | Deposit date: | 2011-11-16 | Release date: | 2011-12-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region. Proc.Natl.Acad.Sci.USA, 108, 2011
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3V55
| Human MALT1 (334-719) in its ligand free form | Descriptor: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Authors: | Renatus, M, Wiesmann, C. | Deposit date: | 2011-12-16 | Release date: | 2012-03-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structural Determinants of MALT1 Protease Activity. J.Mol.Biol., 419, 2012
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3UO8
| Crystal structure of the MALT1 paracaspase (P1 form) | Descriptor: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Z-Val-Arg-Pro-DL-Arg-fluoromethylketone | Authors: | Jeffrey, P.D, Yu, J.W, Shi, Y. | Deposit date: | 2011-11-16 | Release date: | 2011-12-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region. Proc.Natl.Acad.Sci.USA, 108, 2011
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8J5I
| MALT1 death domain | Descriptor: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Authors: | Lo, Y.C, Kuo, B.J. | Deposit date: | 2023-04-22 | Release date: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | MALT1 death domain To Be Published
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3V4O
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7A41
| MALT1 in complex with a NVS-MALT1 chemical probe | Descriptor: | DIMETHYL SULFOXIDE, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, ~{N}-[(1~{S})-1-[4-[[2-chloranyl-7-[(1~{S})-1-methoxyethyl]pyrazolo[1,5-a]pyrimidin-6-yl]amino]phenyl]-2,2,2-tris(fluoranyl)ethyl]-~{N}-methyl-1,1-bis(oxidanylidene)thiane-4-carboxamide | Authors: | Renatus, M. | Deposit date: | 2020-08-19 | Release date: | 2020-12-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | MALT1 in complex with a NVS-MALT1 chemical probe Not Published
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7PAW
| MALT1 in complex with compound 1 | Descriptor: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1, ~{N}1-(3-chloranyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-~{N}4-[2-(trifluoromethyl)pyrimidin-4-yl]cyclohexane-1,4-diamine | Authors: | Kack, H, Oster, L. | Deposit date: | 2021-07-30 | Release date: | 2021-11-17 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Discovery and optimization of cyclohexane-1,4-diamines as allosteric MALT1 inhibitors. Eur.J.Med.Chem., 227, 2021
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7PAV
| MALT1 in complex with compound 1 | Descriptor: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1, ~{N}1,~{N}4-bis[2-(trifluoromethyl)pyrimidin-4-yl]cyclohexane-1,4-diamine | Authors: | Kack, H, Oster, L. | Deposit date: | 2021-07-30 | Release date: | 2021-11-17 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.199 Å) | Cite: | Discovery and optimization of cyclohexane-1,4-diamines as allosteric MALT1 inhibitors. Eur.J.Med.Chem., 227, 2021
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7AK0
| Human MALT1(329-729) in complex with a chromane urea containing inhibitor | Descriptor: | 1-[4-[4-(aminomethyl)pyrazol-1-yl]-3-chloranyl-phenyl]-3-[(3~{R})-6-bromanyl-3,4-dihydro-2~{H}-chromen-3-yl]urea, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Authors: | Renatus, M. | Deposit date: | 2020-09-29 | Release date: | 2020-12-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.316 Å) | Cite: | Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing. J.Med.Chem., 63, 2020
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4I1P
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6F7I
| human MALT1(329-728) IN COMPLEX WITH MLT-747 | Descriptor: | 1-[2-chloranyl-7-[(1~{S})-1-methoxyethyl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-(5-chloranyl-6-pyrrolidin-1-ylcarbonyl-pyridin-3-yl)urea, GLYCEROL, MAGNESIUM ION, ... | Authors: | Renatus, M, Renatus, M. | Deposit date: | 2017-12-09 | Release date: | 2019-01-02 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat. Chem. Biol., 15, 2019
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8V4X
| Structure of MALT1 in complex with an allosteric inhibitor | Descriptor: | Inhibitor peptide, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, N-{7-[(1S)-1-methoxyethyl]-2-methyl[1,3]thiazolo[5,4-b]pyridin-6-yl}-N'-[6-(2H-1,2,3-triazol-2-yl)-5-(trifluoromethyl)pyridin-3-yl]urea | Authors: | Judge, R.A, Pappano, W.N. | Deposit date: | 2023-11-29 | Release date: | 2024-05-01 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.486 Å) | Cite: | Inhibition of MALT1 and BCL2 Induces Synergistic Antitumor Activity in Models of B-Cell Lymphoma. Mol.Cancer Ther., 23, 2024
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7AK1
| Human MALT1(329-729) in complex with a chromane urea containing inhibitor | Descriptor: | 1-(3-chloranyl-4-methoxy-phenyl)-3-[7-[(3~{S})-3-(methoxymethyl)morpholin-4-yl]-2-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]urea, MAGNESIUM ION, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Authors: | Renatus, M. | Deposit date: | 2020-09-29 | Release date: | 2020-12-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.507 Å) | Cite: | Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing. J.Med.Chem., 63, 2020
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6YN9
| MALT1(329-728) in complex with a sulfonamide containing compound | Descriptor: | 5-[4-[(2,6-diethylphenyl)sulfamoyl]-3-methyl-phenyl]furan-3-carboxylic acid, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Authors: | Renatus, M. | Deposit date: | 2020-04-11 | Release date: | 2020-06-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.558 Å) | Cite: | Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity Advanced Therapeutics, 3, 2020
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6H4A
| Human MALT1(329-728) in complex with MLT-748 | Descriptor: | 1-[2-chloranyl-7-[(1~{R},2~{R})-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-[5-chloranyl-6-(1,2,3-triazol-2-yl)pyridin-3-yl]urea, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Authors: | Renatus, M, Renatus, M. | Deposit date: | 2018-07-20 | Release date: | 2019-02-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat. Chem. Biol., 15, 2019
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4I1R
| Human MALT1 (caspase-IG3) in complex with thioridazine | Descriptor: | 10-{2-[(2S)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Authors: | Schlauderer, F, Lammens, K, Hopfner, K.P. | Deposit date: | 2012-11-21 | Release date: | 2013-08-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase. Angew.Chem.Int.Ed.Engl., 52, 2013
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2G7R
| X-ray structure of the death domain of the human mucosa associated lymphoid tissue lymphoma translocation protein 1 | Descriptor: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Authors: | Walker, J.R, Wybenga-Groot, L, Newman, E.M, Finerty Jr, P.J, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-02-28 | Release date: | 2006-04-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | X-ray structure of the death domain of the human mucosa associated lymphoid tissue lymphoma translocation protein 1 To be Published
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3K0W
| Crystal structure of the tandem IG-like C2-type 2 domains of the human mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Descriptor: | CHLORIDE ION, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, isoform 2 | Authors: | Walker, J.R, Qiu, L, Butler-Cole, C, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-25 | Release date: | 2009-10-27 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of the Tandem Ig-Like C2-Type 2 Domains of the Human Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1. To be Published
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6YN8
| Human MALT1(334-719) in complex with a tetrazole containing compound | Descriptor: | 3-azanyl-3-methyl-~{N}-[(3~{R})-4-oxidanylidene-5-[[4-[2-(1~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]-2,3-dihydro-1,5-benzoxazepin-3-yl]butanamide, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Authors: | Renatus, M. | Deposit date: | 2020-04-11 | Release date: | 2020-06-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.052 Å) | Cite: | Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity Advanced Therapeutics, 3, 2020
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8CZO
| Cryo-EM structure of BCL10 CARD - MALT1 DD filament | Descriptor: | B-cell lymphoma/leukemia 10, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Authors: | David, L, Wu, H. | Deposit date: | 2022-05-25 | Release date: | 2022-06-22 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL. Cancer Discov, 12, 2022
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6GK2
| Helical reconstruction of BCL10 CARD and MALT1 DEATH DOMAIN complex | Descriptor: | B-cell lymphoma/leukemia 10, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Authors: | Schlauderer, F, Desfosses, A, Gutsche, I, Hopfner, K.P, Lammens, K. | Deposit date: | 2018-05-18 | Release date: | 2018-10-31 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Molecular architecture and regulation of BCL10-MALT1 filaments. Nat Commun, 9, 2018
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