5NRR
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![BU of 5nrr by Molmil](/molmil-images/mine/5nrr) | |
3FLG
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![BU of 3flg by Molmil](/molmil-images/mine/3flg) | The PWWP domain of Human DNA (cytosine-5-)-methyltransferase 3 beta | Descriptor: | DNA (cytosine-5)-methyltransferase 3B | Authors: | Amaya, M.F, Zeng, H, MacKenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Botchkarev, A, Min, J, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2008-12-18 | Release date: | 2009-03-31 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of the PWWP domain of Human DNA (cytosine-5-)-methyltransferase 3 beta To be Published
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5NV2
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3QKJ
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![BU of 3qkj by Molmil](/molmil-images/mine/3qkj) | The PWWP domain of human DNA (CYTOSINE-5-)-METHYLTRANSFERASE 3 BETA in complex with a bis-tris molecule | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA cytosine-5 methyltransferase 3 beta isoform 6 variant, SULFATE ION | Authors: | Zeng, H, Amaya, M.F, Mackenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Botchkarev, A, Min, J, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2011-02-01 | Release date: | 2011-03-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Structural and Histone Binding Ability Characterizations of Human PWWP Domains. Plos One, 6, 2011
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5NRV
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![BU of 5nrv by Molmil](/molmil-images/mine/5nrv) | Human DNMT3B PWWP domain in complex with 6-dipropylamino-1-hexanol | Descriptor: | 6-dipropylamino-1-hexanol, DNA (cytosine-5)-methyltransferase 3B, SULFATE ION | Authors: | Rondelet, G, Wouters, J. | Deposit date: | 2017-04-25 | Release date: | 2018-06-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.075 Å) | Cite: | Targeting PWWP domain of DNA methyltransferase 3B for epigenetic cancer therapy: Identification and structural characterization of new potential protein-protein interaction inhibitors To be published
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7O45
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![BU of 7o45 by Molmil](/molmil-images/mine/7o45) | Crystal structure of ADD domain of the human DNMT3B methyltransferase | Descriptor: | BROMIDE ION, Isoform 6 of DNA (cytosine-5)-methyltransferase 3B, ZINC ION | Authors: | Boyko, K.M, Nikolaeva, A.Y, Bonchuk, A.N, Georgiev, P.G, Popov, V.O. | Deposit date: | 2021-04-05 | Release date: | 2022-04-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of the DNMT3B ADD domain suggests the absence of a DNMT3A-like autoinhibitory mechanism. Biochem.Biophys.Res.Commun., 619, 2022
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5CIU
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![BU of 5ciu by Molmil](/molmil-images/mine/5ciu) | Structural basis of the recognition of H3K36me3 by DNMT3B PWWP domain | Descriptor: | DNA (cytosine-5)-methyltransferase 3B, GLYCEROL, Histone H3.2 | Authors: | Rondelet, G, DAL MASO, T, Willems, L, Wouters, J. | Deposit date: | 2015-07-13 | Release date: | 2016-03-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B. J.Struct.Biol., 194, 2016
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6R3E
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![BU of 6r3e by Molmil](/molmil-images/mine/6r3e) | Human DNMT3B PWWP domain in complex with triisopropanolamine | Descriptor: | DNA (cytosine-5)-methyltransferase 3B,DNA (cytosine-5)-methyltransferase 3B, SULFATE ION, Triisopropanolamine | Authors: | Rondelet, G, Dal Maso, T, Wouters, J. | Deposit date: | 2019-03-20 | Release date: | 2020-04-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.269 Å) | Cite: | Targeting PWWP domain of DNMT3B for epigenetic cancer therapy: identification and structural characterization of potential protein-protein interaction inhibitors To be published
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5NR3
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![BU of 5nr3 by Molmil](/molmil-images/mine/5nr3) | Human DNMT3B PWWP domain in complex with ethambutol | Descriptor: | DNA (cytosine-5)-methyltransferase 3B, Ethambutol, SULFATE ION | Authors: | Rondelet, G, Wouters, J. | Deposit date: | 2017-04-21 | Release date: | 2018-05-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Targeting PWWP domain of DNA methyltransferase 3B for epigenetic cancer therapy: Identification and structural characterization of new potential protein-protein interaction inhibitors To be published
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5NRS
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![BU of 5nrs by Molmil](/molmil-images/mine/5nrs) | Human DNMT3B PWWP domain in complex with N,N-bis(2-hydroxypropyl)ethanolamine | Descriptor: | (2~{S})-1-[2-hydroxyethyl-[(2~{S})-2-oxidanylpropyl]amino]propan-2-ol, DNA (cytosine-5)-methyltransferase 3B, SULFATE ION | Authors: | Rondelet, G, Wouters, J. | Deposit date: | 2017-04-25 | Release date: | 2018-05-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Targeting PWWP domain of DNA methyltransferase 3B for epigenetic cancer therapy: Identification and structural characterization of new potential protein-protein interaction inhibitors To be published
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5NV0
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![BU of 5nv0 by Molmil](/molmil-images/mine/5nv0) | Human DNMT3B PWWP domain in complex with 4-(dipropylamino)butyronitrile | Descriptor: | 4-(dipropylamino)butanenitrile, DNA (cytosine-5)-methyltransferase 3B, SULFATE ION | Authors: | Rondelet, G, Wouters, J. | Deposit date: | 2017-05-03 | Release date: | 2018-05-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.399 Å) | Cite: | Targeting PWWP domain of DNA methyltransferase 3B for epigenetic cancer therapy: Identification and structural characterization of new potential protein-protein interaction inhibitors To Be Published
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5NVO
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![BU of 5nvo by Molmil](/molmil-images/mine/5nvo) | Human DNMT3B PWWP domain in complex with choline | Descriptor: | CHOLINE ION, DNA (cytosine-5)-methyltransferase 3B, SULFATE ION | Authors: | Rondelet, G, Wouters, J. | Deposit date: | 2017-05-04 | Release date: | 2018-05-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Targeting PWWP domain of DNA methyltransferase 3B for epigenetic cancer therapy: Identification and structural characterization of new potential protein-protein interaction inhibitors To be published
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5NV7
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![BU of 5nv7 by Molmil](/molmil-images/mine/5nv7) | |
6KDB
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![BU of 6kdb by Molmil](/molmil-images/mine/6kdb) | Crystal structure of human DNMT3B-DNMT3L in complex with DNA containing CpGpT site | Descriptor: | DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... | Authors: | Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. | Deposit date: | 2019-07-01 | Release date: | 2020-02-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.862 Å) | Cite: | Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020
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6KDT
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![BU of 6kdt by Molmil](/molmil-images/mine/6kdt) | Crystal structure of human DNMT3B (Q772R)-DNMT3L complex | Descriptor: | DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, FORMIC ACID, ... | Authors: | Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. | Deposit date: | 2019-07-02 | Release date: | 2020-02-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020
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6KDA
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![BU of 6kda by Molmil](/molmil-images/mine/6kda) | Crystal structure of human DNMT3B-DNMT3L in complex with DNA containing CpGpG site | Descriptor: | DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... | Authors: | Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. | Deposit date: | 2019-07-01 | Release date: | 2020-02-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.909 Å) | Cite: | Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020
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6KDP
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![BU of 6kdp by Molmil](/molmil-images/mine/6kdp) | Crystal structure of human DNMT3B-DNMT3L complex (II) | Descriptor: | DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, FORMIC ACID, ... | Authors: | Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. | Deposit date: | 2019-07-02 | Release date: | 2020-02-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.93 Å) | Cite: | Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020
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6PA7
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![BU of 6pa7 by Molmil](/molmil-images/mine/6pa7) | The cryo-EM structure of the human DNMT3A2-DNMT3B3 complex bound to nucleosome. | Descriptor: | CHLORIDE ION, DNA (167-MER), DNA (cytosine-5)-methyltransferase 3A, ... | Authors: | Xu, T.H, Liu, M, Zhou, X.E, Liang, G, Zhao, G, Xu, H.E, Melcher, K, Jones, P.A. | Deposit date: | 2019-06-11 | Release date: | 2020-06-17 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B. Nature, 586, 2020
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6U8W
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![BU of 6u8w by Molmil](/molmil-images/mine/6u8w) | Crystal structure of DNMT3B(K777A)-DNMT3L in complex with CpGpT DNA | Descriptor: | CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... | Authors: | Gao, L, Zhang, Z.M, Song, J. | Deposit date: | 2019-09-06 | Release date: | 2020-06-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.94891548 Å) | Cite: | Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
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6U8X
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![BU of 6u8x by Molmil](/molmil-images/mine/6u8x) | Crystal structure of DNMT3B-DNMT3L in complex with CpApG DNA | Descriptor: | CpApG DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... | Authors: | Gao, L, Song, J. | Deposit date: | 2019-09-06 | Release date: | 2020-06-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.95063877 Å) | Cite: | Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
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6U91
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![BU of 6u91 by Molmil](/molmil-images/mine/6u91) | Crystal structure of DNMT3B(Q772R)-DNMT3L in complex with CpGpT DNA | Descriptor: | CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... | Authors: | Gao, L, Song, J. | Deposit date: | 2019-09-06 | Release date: | 2020-06-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.99998879 Å) | Cite: | Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms To Be Published
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6U8V
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![BU of 6u8v by Molmil](/molmil-images/mine/6u8v) | Crystal structure of DNMT3B-DNMT3L in complex with CpGpT DNA | Descriptor: | CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... | Authors: | Gao, L, Zhang, Z.M, Song, J. | Deposit date: | 2019-09-06 | Release date: | 2020-06-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
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6U90
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![BU of 6u90 by Molmil](/molmil-images/mine/6u90) | Crystal structure of DNMT3B(N779A)-DNMT3L in complex with CpGpT DNA | Descriptor: | CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... | Authors: | Gao, L, Song, J. | Deposit date: | 2019-09-06 | Release date: | 2020-06-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.00081754 Å) | Cite: | Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms To Be Published
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8EIH
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![BU of 8eih by Molmil](/molmil-images/mine/8eih) | Cryo-EM structure of human DNMT3B homo-tetramer (form I) | Descriptor: | DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | Authors: | Lu, J.W, Song, J.K. | Deposit date: | 2022-09-15 | Release date: | 2023-09-20 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. Nucleic Acids Res., 51, 2023
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6U8P
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![BU of 6u8p by Molmil](/molmil-images/mine/6u8p) | Crystal structure of DNMT3B-DNMT3L in complex with CpGpA DNA | Descriptor: | CpGpA DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... | Authors: | Gao, L, Song, J. | Deposit date: | 2019-09-05 | Release date: | 2020-06-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
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