5NVO

Human DNMT3B PWWP domain in complex with choline

Summary for 5NVO

• Entry DOI: 10.2210/pdb5nvo/pdb
• Descriptor: DNA (cytosine-5)-methyltransferase 3B, CHOLINE ION, SULFATE ION, ... (4 entities in total)
• Functional Keywords: dnmt3b pwwp domain, histone binding, beta barrel, ligand, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 34470.60

Authors

Rondelet, G.,Wouters, J. (deposition date: 2017-05-04, release date: 2018-05-30, Last modification date: 2024-01-17)

• Primary citation: Rondelet, G.,Dal Maso, T.,Maniquet, A.,Themans, Q.,Wouters, J.; Targeting PWWP domain of DNA methyltransferase 3B for epigenetic cancer therapy: Identification and structural characterization of new potential protein-protein interaction inhibitors; To be published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)