6R3E
Human DNMT3B PWWP domain in complex with triisopropanolamine
Summary for 6R3E
Entry DOI | 10.2210/pdb6r3e/pdb |
Descriptor | DNA (cytosine-5)-methyltransferase 3B,DNA (cytosine-5)-methyltransferase 3B, Triisopropanolamine, SULFATE ION, ... (4 entities in total) |
Functional Keywords | dnmt3b pwwp domain, histone binding, beta barrel, ligand, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 62334.31 |
Authors | Rondelet, G.,Dal Maso, T.,Wouters, J. (deposition date: 2019-03-20, release date: 2020-04-08, Last modification date: 2024-01-24) |
Primary citation | Rondelet, G.,Dal Maso, T.,Maniquet, A.,Themans, Q.,Wouters, J. Targeting PWWP domain of DNMT3B for epigenetic cancer therapy: identification and structural characterization of potential protein-protein interaction inhibitors To be published, |
Experimental method | X-RAY DIFFRACTION (2.269 Å) |
Structure validation
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