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PDB: 14 results

6UXE
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BU of 6uxe by Molmil
Structure of the human mitochondrial desulfurase complex Nfs1-ISCU2(M140I)-ISD11 with E.coli ACP1 at 1.57 A resolution showing flexibility of N terminal end of ISCU2
Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ...
Authors:Boniecki, M.T, Cygler, M.
Deposit date:2019-11-07
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published
6W1D
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BU of 6w1d by Molmil
Structure of human mitochondrial complex Nfs1-ISCU2 (WT)-ISD11 with E.coli ACP1 at 1.8 A resolution (NIAU)2
Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ...
Authors:Boniecki, M.T, Cygler, M.
Deposit date:2020-03-04
Release date:2020-03-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.795 Å)
Cite:The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published
6WIH
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BU of 6wih by Molmil
N-terminal mutation of ISCU2 (L35H36) traps Nfs1 Cys loop in the active site of ISCU2 without metal present. Structure of human mitochondrial complex Nfs1-ISCU2(L35H36)-ISD11 with E.coli ACP1 at 1.9 A resolution (NIAU)2.
Descriptor: 1,2-ETHANEDIOL, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, Acyl carrier protein, ...
Authors:Boniecki, M.T, Cygler, M.
Deposit date:2020-04-09
Release date:2020-05-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published
6WI2
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BU of 6wi2 by Molmil
Structure of human mitochondrial complex Nfs1-ISCU2-ISD11 with E.coli ACP1 at 1.95 A resolution (NIAU)2. N-terminal mutation of ISCU2 (L35) traps Nfs1 Cys loop in the active site of ISCU2 without metal present.
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ...
Authors:Boniecki, M.T, Cygler, M.
Deposit date:2020-04-08
Release date:2020-04-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published
6ODD
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BU of 6odd by Molmil
Crystal structure of the human complex ACP-ISD11
Descriptor: Acyl carrier protein, mitochondrial, CALCIUM ION, ...
Authors:Herrera, M.G, Noguera, M.E, Klinke, S, Santos, J.
Deposit date:2019-03-26
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the Human ACP-ISD11 Heterodimer.
Biochemistry, 58, 2019
8PK8
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BU of 8pk8 by Molmil
Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide transfer (persulfide on ISCU2)
Descriptor: Acyl carrier protein, Cysteine desulfurase, FE (II) ION, ...
Authors:Steinhilper, R, Murphy, B.J.
Deposit date:2023-06-26
Release date:2024-05-01
Method:ELECTRON MICROSCOPY (2.49 Å)
Cite:Mechanism and structural dynamics of sulfur transfer during de novo [2Fe-2S] cluster assembly on ISCU2.
Nat Commun, 15, 2024
7RTK
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BU of 7rtk by Molmil
Structure of the (NIAU)2 complex with N-terminal mutation of ISCU2 Y35D at 2.5 A resolution
Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ...
Authors:Boniecki, M.T, Cygler, M.
Deposit date:2021-08-13
Release date:2021-08-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published
8PK9
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BU of 8pk9 by Molmil
Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide transfer (persulfide on NFS1 and ISCU2)
Descriptor: Acyl carrier protein, Cysteine desulfurase, FE (II) ION, ...
Authors:Steinhilper, R, Murphy, B.J.
Deposit date:2023-06-26
Release date:2024-05-01
Method:ELECTRON MICROSCOPY (2.58 Å)
Cite:Mechanism and structural dynamics of sulfur transfer during de novo [2Fe-2S] cluster assembly on ISCU2.
Nat Commun, 15, 2024
5WGB
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BU of 5wgb by Molmil
Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and E. coli ACP1 protein at 2.75A
Descriptor: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ...
Authors:Boniecki, M.T, Cygler, M.
Deposit date:2017-07-13
Release date:2017-07-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.
Nat Commun, 8, 2017
8PKA
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BU of 8pka by Molmil
Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide transfer (without frataxin)
Descriptor: Acyl carrier protein, Cysteine desulfurase, FE (II) ION, ...
Authors:Steinhilper, R, Murphy, B.J.
Deposit date:2023-06-26
Release date:2024-05-01
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:Mechanism and structural dynamics of sulfur transfer during de novo [2Fe-2S] cluster assembly on ISCU2.
Nat Commun, 15, 2024
5USR
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BU of 5usr by Molmil
Crystal structure of human NFS1-ISD11 in complex with E. coli acyl-carrier protein at 3.09 angstroms
Descriptor: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ...
Authors:Cory, S.A, Barondeau, D.P.
Deposit date:2017-02-13
Release date:2017-06-21
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WKP
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BU of 5wkp by Molmil
Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and Iron-Sulfur Cluster Scaffold Protein ISCU1, and E. coli ACP1 protein at 3.15A
Descriptor: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ...
Authors:Boniecki, M.T, Cygler, M.
Deposit date:2017-07-25
Release date:2017-11-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.
Nat Commun, 8, 2017
6NZU
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BU of 6nzu by Molmil
Structure of the human frataxin-bound iron-sulfur cluster assembly complex
Descriptor: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ...
Authors:Fox, N.G, Yu, X, Xidong, F, Alain, M, Joseph, N, Claire, S.D, Christine, B, Han, S, Yue, W.W.
Deposit date:2019-02-14
Release date:2019-05-22
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism.
Nat Commun, 10, 2019
5WLW
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BU of 5wlw by Molmil
Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine Loop within ISCU1 active site, coordinating Zn ion. Complexed with human ISD11 and E. coli ACP1 at 3.3A.
Descriptor: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ...
Authors:Boniecki, M.T, Cygler, M.
Deposit date:2017-07-27
Release date:2017-11-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.317 Å)
Cite:Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.
Nat Commun, 8, 2017

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