6WIH

N-terminal mutation of ISCU2 (L35H36) traps Nfs1 Cys loop in the active site of ISCU2 without metal present. Structure of human mitochondrial complex Nfs1-ISCU2(L35H36)-ISD11 with E.coli ACP1 at 1.9 A resolution (NIAU)2.

Summary for 6WIH

• Entry DOI: 10.2210/pdb6wih/pdb
• Descriptor: Cysteine desulfurase, mitochondrial, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, TRIETHYLENE GLYCOL, ... (15 entities in total)
• Functional Keywords: complex, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 86192.08

Authors

Boniecki, M.T.,Cygler, M. (deposition date: 2020-04-09, release date: 2020-05-13, Last modification date: 2023-10-18)

• Primary citation: Freibert, S.A.,Boniecki, M.T.,Shulz, V.,Wilbrecht, C.,Krapoth, N.,Muhlenhoff, U.,Stehling, O.,Cygler, M.,Lill, R.; The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)