6WI2

Structure of human mitochondrial complex Nfs1-ISCU2-ISD11 with E.coli ACP1 at 1.95 A resolution (NIAU)2. N-terminal mutation of ISCU2 (L35) traps Nfs1 Cys loop in the active site of ISCU2 without metal present.

Summary for 6WI2

• Entry DOI: 10.2210/pdb6wi2/pdb
• Descriptor: Cysteine desulfurase, mitochondrial, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, TRIETHYLENE GLYCOL, ... (16 entities in total)
• Functional Keywords: complex, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 85745.59

Authors

Boniecki, M.T.,Cygler, M. (deposition date: 2020-04-08, release date: 2020-04-22, Last modification date: 2023-10-18)

• Primary citation: Freibert, S.A.,Boniecki, M.T.,Shulz, V.,Wilbrecht, C.,Krapoth, N.,Muhlenhoff, U.,Stehling, O.,Cygler, M.,Lill, R.; The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)