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6WI2

Structure of human mitochondrial complex Nfs1-ISCU2-ISD11 with E.coli ACP1 at 1.95 A resolution (NIAU)2. N-terminal mutation of ISCU2 (L35) traps Nfs1 Cys loop in the active site of ISCU2 without metal present.

Summary for 6WI2
Entry DOI10.2210/pdb6wi2/pdb
DescriptorCysteine desulfurase, mitochondrial, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, TRIETHYLENE GLYCOL, ... (16 entities in total)
Functional Keywordscomplex, transferase
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight85745.59
Authors
Boniecki, M.T.,Cygler, M. (deposition date: 2020-04-08, release date: 2020-04-22, Last modification date: 2023-10-18)
Primary citationFreibert, S.A.,Boniecki, M.T.,Shulz, V.,Wilbrecht, C.,Krapoth, N.,Muhlenhoff, U.,Stehling, O.,Cygler, M.,Lill, R.
The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

217705

PDB entries from 2024-03-27

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