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6WI2

Structure of human mitochondrial complex Nfs1-ISCU2-ISD11 with E.coli ACP1 at 1.95 A resolution (NIAU)2. N-terminal mutation of ISCU2 (L35) traps Nfs1 Cys loop in the active site of ISCU2 without metal present.

Functional Information from GO Data
ChainGOidnamespacecontents
A0030170molecular_functionpyridoxal phosphate binding
A0031071molecular_functioncysteine desulfurase activity
A0044571biological_process[2Fe-2S] cluster assembly
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0016226biological_processiron-sulfur cluster assembly
B0016604cellular_componentnuclear body
B0042803molecular_functionprotein homodimerization activity
B0044571biological_process[2Fe-2S] cluster assembly
B0044572biological_process[4Fe-4S] cluster assembly
B0099128cellular_componentmitochondrial [2Fe-2S] assembly complex
B1990221cellular_componentL-cysteine desulfurase complex
B1990229cellular_componentiron-sulfur cluster assembly complex
C0000035molecular_functionacyl binding
C0000036molecular_functionacyl carrier activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006633biological_processfatty acid biosynthetic process
C0008289molecular_functionlipid binding
C0008610biological_processlipid biosynthetic process
C0009245biological_processlipid A biosynthetic process
C0009410biological_processresponse to xenobiotic stimulus
C0031177molecular_functionphosphopantetheine binding
D0005506molecular_functioniron ion binding
D0016226biological_processiron-sulfur cluster assembly
D0051536molecular_functioniron-sulfur cluster binding
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue PLP A 501
ChainResidue
AGLY126
AHIS257
ALYS258
ATHR295
AHOH647
AHOH726
AALA127
ATHR128
AHIS156
AMET203
AASP232
AALA234
AGLN235
ASER255

site_idAC2
Number of Residues5
Detailsbinding site for residue EDO A 502
ChainResidue
AARG321
ATHR415
AGLU416
AGLU417
BARG34

site_idAC3
Number of Residues5
Detailsbinding site for residue EDO A 503
ChainResidue
AVAL173
ATHR174
ATYR175
APEG527
AHOH720

site_idAC4
Number of Residues5
Detailsbinding site for residue GOL A 504
ChainResidue
ALYS431
AARG434
AGLU435
ATRP440
AHOH630

site_idAC5
Number of Residues8
Detailsbinding site for residue PEG A 505
ChainResidue
AILE270
AARG271
AARG272
AARG275
AVAL276
AVAL278
AMET291
AHOH620

site_idAC6
Number of Residues6
Detailsbinding site for residue PEG A 506
ChainResidue
AGLY115
AALA116
AASP117
APG4520
AEDO528
AHOH649

site_idAC7
Number of Residues9
Detailsbinding site for residue EDO A 507
ChainResidue
ALEU69
ATYR80
ALEU81
APRO262
ALYS263
APRO299
AHOH613
AHOH653
AHOH707

site_idAC8
Number of Residues10
Detailsbinding site for residue GOL A 508
ChainResidue
APRO58
ATHR92
AHIS93
AALA94
ALEU367
AMET368
ALEU370
ALYS371
AEDO511
AHOH779

site_idAC9
Number of Residues8
Detailsbinding site for residue EDO A 509
ChainResidue
AMET368
AALA369
ALYS371
AHIS429
APEG539
DVAL40
DTYR43
DGLU44

site_idAD1
Number of Residues2
Detailsbinding site for residue EDO A 510
ChainResidue
AMET334
ALEU337

site_idAD2
Number of Residues8
Detailsbinding site for residue EDO A 511
ChainResidue
APRO58
ATRP97
ALYS371
AGOL508
AHOH639
AHOH791
AHOH844
DLEU35

site_idAD3
Number of Residues4
Detailsbinding site for residue EDO A 512
ChainResidue
ALYS157
AARG164
APEG527
AHOH690

site_idAD4
Number of Residues5
Detailsbinding site for residue EDO A 513
ChainResidue
AGLU104
AARG105
AGLN108
AHOH615
AHOH632

site_idAD5
Number of Residues5
Detailsbinding site for residue EDO A 514
ChainResidue
AGLU100
AALA101
AHOH615
AHOH636
AHOH811

site_idAD6
Number of Residues5
Detailsbinding site for residue EDO A 515
ChainResidue
ALYS248
AASP250
AARG271
AHOH606
AHOH702

site_idAD7
Number of Residues8
Detailsbinding site for residue EDO A 516
ChainResidue
ASER125
ASER125
AARG292
ATHR295
AHOH647
AHOH665
AHOH665
AHOH737

site_idAD8
Number of Residues4
Detailsbinding site for residue EDO A 517
ChainResidue
AGLU316
AHOH748
BGLU42
BEDO1605

site_idAD9
Number of Residues8
Detailsbinding site for residue EDO A 518
ChainResidue
AGLN179
ASER181
AILE183
AASP345
AHOH601
AHOH619
DASN45
DHOH303

site_idAE1
Number of Residues5
Detailsbinding site for residue PEG A 519
ChainResidue
AASP75
AHOH858
BARG68
BLEU75
BSER77

site_idAE2
Number of Residues9
Detailsbinding site for residue PG4 A 520
ChainResidue
AGLN108
ASER112
AALA116
AGLN312
AGLN313
APEG506
AHOH635
AHOH649
AHOH769

site_idAE3
Number of Residues4
Detailsbinding site for residue PG4 A 521
ChainResidue
AARG328
AASN332
AILE427
AHOH741

site_idAE4
Number of Residues2
Detailsbinding site for residue PEG A 522
ChainResidue
APRO241
AHIS319

site_idAE5
Number of Residues5
Detailsbinding site for residue EDO A 523
ChainResidue
AARG220
ASER224
ALYS248
DARG89
DEDO203

site_idAE6
Number of Residues2
Detailsbinding site for residue EDO A 524
ChainResidue
AARG119
AARG272

site_idAE7
Number of Residues1
Detailsbinding site for residue EDO A 525
ChainResidue
AGLN312

site_idAE8
Number of Residues9
Detailsbinding site for residue ETE A 526
ChainResidue
ALEU337
APRO338
AASP339
AVAL340
ATYR360
AASP400
ALEU401
AHOH756
AHOH813

site_idAE9
Number of Residues4
Detailsbinding site for residue PEG A 527
ChainResidue
AGLN153
AARG164
AEDO503
AEDO512

site_idAF1
Number of Residues4
Detailsbinding site for residue EDO A 528
ChainResidue
AGLN108
AASP117
APRO118
APEG506

site_idAF2
Number of Residues4
Detailsbinding site for residue PEG A 529
ChainResidue
AGLN331
AMET342
AHOH616
AHOH786

site_idAF3
Number of Residues3
Detailsbinding site for residue EDO A 530
ChainResidue
AGLU416
AGLU417
AASP420

site_idAF4
Number of Residues4
Detailsbinding site for residue EDO A 531
ChainResidue
AGLU217
AHOH652
DARG47
DASN48

site_idAF5
Number of Residues4
Detailsbinding site for residue EDO A 532
ChainResidue
AASP420
ATYR421
AGLU424
AHOH697

site_idAF6
Number of Residues4
Detailsbinding site for residue EDO A 534
ChainResidue
AGLN428
AARG432
AHOH661
AHOH716

site_idAF7
Number of Residues13
Detailsbinding site for residue PGE A 535
ChainResidue
AALA76
AARG105
AGLN109
AALA306
AGLU309
AVAL310
AGLN313
AHOH607
AHOH623
AHOH681
AHOH712
BARG61
BHOH1755

site_idAF8
Number of Residues2
Detailsbinding site for residue EDO A 536
ChainResidue
AGLU314
BARG35

site_idAF9
Number of Residues7
Detailsbinding site for residue PEG A 537
ChainResidue
AASP161
ASER283
AGLY284
AGLY286
AGLY290
AHOH621
AHOH772

site_idAG1
Number of Residues8
Detailsbinding site for residue EDO A 538
ChainResidue
ALYS212
APRO346
ALYS347
AHIS348
AHIS349
AHOH732
AHOH806
AHOH841

site_idAG2
Number of Residues9
Detailsbinding site for residue PEG A 539
ChainResidue
AGLN179
AASP185
ALYS371
ALYS425
AGLN428
AHIS429
AARG432
AEDO509
DGLU44

site_idAG3
Number of Residues2
Detailsbinding site for residue PEG A 540
ChainResidue
AHOH822
AHOH856

site_idAG4
Number of Residues7
Detailsbinding site for residue EDO B 1601
ChainResidue
APRO68
ATYR85
APHE413
ATHR414
AHOH682
BASN27
BHOH1703

site_idAG5
Number of Residues2
Detailsbinding site for residue EDO B 1602
ChainResidue
AASP445
BLEU12

site_idAG6
Number of Residues4
Detailsbinding site for residue EDO B 1603
ChainResidue
AVAL443
AGLN444
BARG61
BHOH1716

site_idAG7
Number of Residues4
Detailsbinding site for residue MES B 1604
ChainResidue
BARG41
BLYS44
CASP35
CASP38

site_idAG8
Number of Residues5
Detailsbinding site for residue EDO B 1605
ChainResidue
AEDO517
AHOH774
BHOH1708
BHOH1736
BHOH1751

site_idAG9
Number of Residues3
Detailsbinding site for residue EDO B 1606
ChainResidue
AASP445
BARG67
BPEG1607

site_idAH1
Number of Residues5
Detailsbinding site for residue PEG B 1607
ChainResidue
BARG67
BARG68
BLEU75
BEDO1606
BHOH1744

site_idAH2
Number of Residues3
Detailsbinding site for residue EDO B 1608
ChainResidue
BLYS21
BPHE23
BLYS80

site_idAH3
Number of Residues5
Detailsbinding site for residue EDT B 1609
ChainResidue
AGLU417
BLYS21
BARG29
BGLU84
BHOH1721

site_idAH4
Number of Residues12
Detailsbinding site for residue 8Q1 C 301
ChainResidue
BARG6
BVAL9
BALA39
BASN43
BLYS44
BVAL46
BHOH1735
CASP35
CSER36
CEDO302
CHOH409
CHOH413

site_idAH5
Number of Residues4
Detailsbinding site for residue EDO C 302
ChainResidue
CVAL29
CSER36
C8Q1301
CHOH402

site_idAH6
Number of Residues4
Detailsbinding site for residue EDO C 303
ChainResidue
CPRO55
CTYR71
CHIS75
DLYS57

site_idAH7
Number of Residues3
Detailsbinding site for residue EDO D 201
ChainResidue
DGLN38
DLYS127
DGLU128

site_idAH8
Number of Residues4
Detailsbinding site for residue EDO D 202
ChainResidue
AGLU435
DGLY50
DLYS91
DEDO203

site_idAH9
Number of Residues6
Detailsbinding site for residue EDO D 203
ChainResidue
AARG220
AEDO523
DGLY50
DSER51
DARG89
DEDO202

site_idAI1
Number of Residues5
Detailsbinding site for residue 1PE D 204
ChainResidue
DGLY111
DLYS112
DGLU116
DTHR119
DILE120

site_idAI2
Number of Residues5
Detailsbinding site for residue GOL D 205
ChainResidue
BARG14
BHOH1727
CASP56
DASP53
DTHR55

site_idAI3
Number of Residues3
Detailsbinding site for residue EDO D 206
ChainResidue
DGLU107
DTRP108
DHOH321

Functional Information from PROSITE/UniProt
site_idPS00012
Number of Residues16
DetailsPHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGADSLDTVELVMAL
ChainResidueDetails
CASP31-LEU46

site_idPS00595
Number of Residues20
DetailsAA_TRANSFER_CLASS_5 Aminotransferases class-V pyridoxal-phosphate attachment site. IDLMsiSGHKiygpk.GvGaI
ChainResidueDetails
AILE249-ILE268

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Cysteine persulfide intermediate => ECO:0000250|UniProtKB:Q9D7P6
ChainResidueDetails
DGLY94
BLYS44

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Cysteine persulfide intermediate => ECO:0000250|UniProtKB:O29689
ChainResidueDetails
DGLU163

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:31101807, ECO:0007744|PDB:6NZU
ChainResidueDetails
DGLY96
DILE120
DGLU163
AHIS257

site_idSWS_FT_FI4
Number of Residues1
DetailsSITE: Mediates ISCU dimerization and de novo [2Fe-2S] cluster assembly => ECO:0000269|PubMed:34824239
ChainResidueDetails
DGLY60

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by MTOR => ECO:0000269|PubMed:23508953
ChainResidueDetails
DVAL39

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Cysteine persulfide => ECO:0000250|UniProtKB:Q9D7P6
ChainResidueDetails
DGLY94

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Cysteine persulfide => ECO:0000305|PubMed:24971490
ChainResidueDetails
DGLU163

224572

PDB entries from 2024-09-04

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