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PDB: 35 results
5C33
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Crystal Structure of Mouse Ryanodine Receptor 2 SPRY1 Domain
Descriptor: CHLORIDE ION, ISOPROPYL ALCOHOL, Ryanodine receptor 2
Authors:Yuchi, Z, Van Petegem, F.
Deposit date:2015-06-16
Release date:2015-08-05
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant.
Nat Commun, 6, 2015
4P9I
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BU of 4p9i by Molmil
Crystal Structure of mouse Ryanodine Receptor 2 SPRY2 Domain (1080-1253)
Descriptor: Ryanodine receptor 2
Authors:Lau, K, Van Petegem, F.
Deposit date:2014-04-04
Release date:2014-11-05
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.3401 Å)
Cite:Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.
Nat Commun, 5, 2014
4P9L
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BU of 4p9l by Molmil
Crystal Structure of mouse Ryanodine Receptor 2 SPRY2 Domain (1080-1253) disease mutant A1107M
Descriptor: Ryanodine receptor 2
Authors:Lau, K, Van Petegem, F.
Deposit date:2014-04-04
Release date:2014-11-05
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.4361 Å)
Cite:Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.
Nat Commun, 5, 2014
5VSN
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Crystal structure of mouse ryanodine receptor 2 SPRY2 domain (1080-1253) disease mutant P1124L
Descriptor: GLYCEROL, POTASSIUM ION, Ryanodine receptor 2
Authors:Yuchi, Z, Van Petegem, F.
Deposit date:2017-05-12
Release date:2018-05-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.439 Å)
Cite:Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2.
JCI Insight, 5, 2019
6J6L
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BU of 6j6l by Molmil
Crystal structure of mouse Ryanodine Receptor 2 SPRY1 Domain (650-844) disease mutant I784F
Descriptor: ISOPROPYL ALCOHOL, Ryanodine receptor 2
Authors:Ma, R, Lin, L, Yuchi, Z.
Deposit date:2019-01-15
Release date:2020-01-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.452 Å)
Cite:A SPRY1 domain cardiac ryanodine receptor variant associated with short-coupled torsade de pointes.
Sci Rep, 11, 2021
4ETV
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BU of 4etv by Molmil
Crystal structure of mouse ryanodine receptor 2 (2699-2904)
Descriptor: CHLORIDE ION, Ryanodine receptor 2
Authors:Yuchi, Z, Lau, K, Van Petegem, F.
Deposit date:2012-04-24
Release date:2012-06-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Disease mutations in the ryanodine receptor central region: crystal structures of a phosphorylation hot spot domain.
Structure, 20, 2012
3IM6
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BU of 3im6 by Molmil
Crystal structure of mouse Ryanodine Receptor 2 mutant V186M
Descriptor: Cardiac Ca2+ release channel, SULFATE ION
Authors:Van Petegem, F, Lobo, P.A.
Deposit date:2009-08-09
Release date:2009-11-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of the N-terminal domains of cardiac and skeletal muscle ryanodine receptors: insights into disease mutations.
Structure, 17, 2009
6Y4O
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BU of 6y4o by Molmil
Calmodulin bound to cardiac ryanodine receptor (RyR2) calmodulin binding domain
Descriptor: CALCIUM ION, Calmodulin-2, Ryanodine receptor 2
Authors:Lau, K, Nielsen, L.H, Holt, C, Brohus, M, Sorensen, A.B, Larsen, K.T, Sommer, C, Van Petegem, F, Overgaard, M.T, Wimmer, R.
Deposit date:2020-02-21
Release date:2020-04-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.83549082 Å)
Cite:The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor.
J.Biol.Chem., 295, 2020
6MM7
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BU of 6mm7 by Molmil
Catalytic subunit of cAMP-dependent protein kinase A in complex with RyR2 K2879A, S2813D phosphomimetic (2699-2904) crystal form 1
Descriptor: 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ...
Authors:van Petegem, F, Haji-Ghassemi, O.
Deposit date:2018-09-29
Release date:2019-05-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:cAMP-dependent protein kinase A in complex with RyR2 peptide (2799-2810)
Mol.Cell, 2019
6MM8
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BU of 6mm8 by Molmil
Catalytic subunit of cAMP-dependent protein kinase A in complex with RyR2 K2879A, S2813D phosphomimetic (2699-2904) crystal form 2
Descriptor: 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ...
Authors:van Petegem, F, Haji-Ghassemi, O.
Deposit date:2018-09-29
Release date:2019-05-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:cAMP-dependent protein kinase A in complex with RyR2 peptide (2799-2810)
Mol.Cell, 2019
6MM5
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BU of 6mm5 by Molmil
Catalytic subunit of cAMP-dependent protein kinase A in complex with RyR2 peptide (2799-2810)
Descriptor: 1,2-ETHANEDIOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:van Petegem, F, Haji-Ghassemi, O.
Deposit date:2018-09-29
Release date:2019-05-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:cAMP-dependent protein kinase A in complex with RyR2 peptide (2799-2810)
Mol.Cell, 2019
4L4H
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BU of 4l4h by Molmil
Crystal structure of mouse Ryanodine Receptor isoform 2 (RyR2) 1-547
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Ryanodine receptor 2, ...
Authors:Kimlicka, L, Tung, C.C, Van Petegem, F.
Deposit date:2013-06-07
Release date:2013-07-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a ryanodine receptor domain
To be Published
6Y4P
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BU of 6y4p by Molmil
Calmodulin N53I variant bound to cardiac ryanodine receptor (RyR2) calmodulin binding domain
Descriptor: CALCIUM ION, Calmodulin-1, Ryanodine receptor 2
Authors:Lau, K, Nielsen, L.H, Holt, C, Brohus, M, Sorensen, A.B, Larsen, K.T, Sommer, C, Van Petegem, F, Overgaard, M.T, Wimmer, R.
Deposit date:2020-02-21
Release date:2020-04-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.13325572 Å)
Cite:The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor.
J.Biol.Chem., 295, 2020
4KEK
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BU of 4kek by Molmil
Crystal structure of mouse Ryanodine Receptor 2 (1-217) disease mutant R176Q
Descriptor: Ryanodine receptor 2, SULFATE ION
Authors:Kimlicka, L, Van Petegem, F.
Deposit date:2013-04-25
Release date:2013-09-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.146 Å)
Cite:Type 2 Ryanodine Receptor Domain A Contains a Unique and Dynamic alpha-Helix That Transitions to a beta-Strand in a Mutant Linked with a Heritable Cardiomyopathy.
J.Mol.Biol., 425, 2013
4L4I
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BU of 4l4i by Molmil
Crystal structure of mouse Ryanodine Receptor isoform 2 (RyR2) 1-547 disease mutant R420Q
Descriptor: GLYCEROL, Ryanodine receptor 2
Authors:Kimlicka, L, Van Petegem, F.
Deposit date:2013-06-07
Release date:2013-07-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of ryanodine receptor disease mutant
To be Published
3IM7
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BU of 3im7 by Molmil
Crystal structure of mouse Ryanodine Receptor 2 N-terminal domain (1-217) disease mutant A77V
Descriptor: Cardiac Ca2+ release channel, SULFATE ION
Authors:Van Petegem, F, Lobo, P.A.
Deposit date:2009-08-09
Release date:2009-11-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Crystal structures of the N-terminal domains of cardiac and skeletal muscle ryanodine receptors: insights into disease mutations.
Structure, 17, 2009
3QR5
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BU of 3qr5 by Molmil
Structure of the first domain of a cardiac Ryanodine Receptor mutant with exon 3 deleted
Descriptor: Cardiac Ca2+ release channel
Authors:Lobo, P.A, Van Petegem, F.
Deposit date:2011-02-17
Release date:2011-06-08
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The deletion of exon 3 in the cardiac ryanodine receptor is rescued by beta strand switching.
Structure, 19, 2011
6MM6
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BU of 6mm6 by Molmil
Catalytic subunit of cAMP-dependent protein kinase A in complex with RyR2 phosphorylation domain (2699-2904)
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ...
Authors:van Petegem, F, Haji-Ghassemi, O.
Deposit date:2018-09-29
Release date:2019-05-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:cAMP-dependent protein kinase A in complex with RyR2 peptide (2799-2810)
Mol.Cell, 2019
4KEI
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BU of 4kei by Molmil
Crystal structure of mouse Ryanodine Receptor 2 (1-217) disease mutant P164S
Descriptor: Ryanodine receptor 2
Authors:Kimlicka, L, Van Petegem, F.
Deposit date:2013-04-25
Release date:2013-09-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.406 Å)
Cite:Type 2 Ryanodine Receptor Domain A Contains a Unique and Dynamic alpha-Helix That Transitions to a beta-Strand in a Mutant Linked with a Heritable Cardiomyopathy.
J.Mol.Biol., 425, 2013
3IM5
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BU of 3im5 by Molmil
Crystal structure of mouse Ryanodine Receptor 2 (residues 1-217)
Descriptor: Cardiac Ca2+ release channel
Authors:Van Petegem, F, Lobo, P.A.
Deposit date:2009-08-09
Release date:2009-11-17
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structures of the N-terminal domains of cardiac and skeletal muscle ryanodine receptors: insights into disease mutations.
Structure, 17, 2009
4KEJ
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BU of 4kej by Molmil
Crystal structure of mouse Ryanodine Receptor 2 (1-217) disease mutant R169Q
Descriptor: Ryanodine receptor 2
Authors:Kimlicka, L, Van Petegem, F.
Deposit date:2013-04-25
Release date:2013-09-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.553 Å)
Cite:Type 2 Ryanodine Receptor Domain A Contains a Unique and Dynamic alpha-Helix That Transitions to a beta-Strand in a Mutant Linked with a Heritable Cardiomyopathy.
J.Mol.Biol., 425, 2013
6WOU
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BU of 6wou by Molmil
Cryo-EM structure of recombinant mouse Ryanodine Receptor type 2 mutant R176Q in complex with FKBP12.6 in nanodisc
Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ZINC ION
Authors:Iyer, K.A, Hu, Y, Kurebayashi, N, Murayama, T, Samso, M.
Deposit date:2020-04-25
Release date:2020-08-05
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM.
Sci Adv, 6, 2020
7VML
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BU of 7vml by Molmil
Structure of recombinant RyR2 (EGTA dataset, class 1&2, closed state)
Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ZINC ION
Authors:Kobayashi, T, Tsutsumi, A, Kurebayashi, N, Kodama, M, Kikkawa, M, Murayama, T, Ogawa, H.
Deposit date:2021-10-09
Release date:2022-08-10
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations.
Nat Commun, 13, 2022
7VMR
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BU of 7vmr by Molmil
Structure of recombinant RyR2 mutant K4593A (EGTA dataset)
Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ZINC ION
Authors:Kobayashi, T, Tsutsumi, A, Kurebayashi, N, Kodama, M, Kikkawa, M, Murayama, T, Ogawa, H.
Deposit date:2021-10-09
Release date:2022-08-10
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations.
Nat Commun, 13, 2022
8DTY
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BU of 8dty by Molmil
Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under closed-state conditions
Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ZINC ION
Authors:Iyer, K.A, Hu, Y, Murayama, T, Samso, M.
Deposit date:2022-07-26
Release date:2024-01-31
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under closed-state conditions
To Be Published

 

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